Blocking the CCL5–CCR5 Axis Using Maraviroc Promotes M1 Polarization of Macrophages Cocultured with Irradiated Hepatoma Cells

Tumor associated macrophages and ‘NO’

(2020) Niharika Nath et al.   BIOCHEMICAL PHARMACOLOGY

Biological and Clinical Significance of the CCR5/CCL5 Axis in Hepatocellular Carcinoma

(2020) Santosh K. Singh et al.   Cancers

Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages

(2020) Si Mi et al.   OncoTargets and Therapy

Breast phyllodes tumors recruit and repolarize tumor-associated macrophages via secreting CCL5 to promote malignant progression which can be inhibited by CCR5 inhibition Therapy

(2019) Hai Hu et al.   CLINICAL CANCER RESEARCH

Diffusion-weighted MRI and 18F-FDG PET correlation with immunity in early radiotherapy response in BNL hepatocellular carcinoma mouse model: timeline validation

(2019) Yi-Hsiu Chung et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

(2019) Andrea Walens et al.   eLife

CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization

(2019) Meng Li et al.   Cellular & Molecular Immunology

Asaronic Acid Attenuates Macrophage Activation toward M1 Phenotype through Inhibition of NF-κB Pathway and JAK-STAT Signaling in Glucose-Loaded Murine Macrophages

(2019) Hyeongjoo Oh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Luteolin Alters Macrophage Polarization to Inhibit Inflammation

(2019) Shuxia Wang et al.   INFLAMMATION

Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma

(2018) Valerie Chew et al.   GUT

Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer

(2018) Omar M. Rahal et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

CCR5 antagonism by maraviroc inhibits Hodgkin lymphoma microenvironment interactions and xenograft growth

(2018) Naike Casagrande et al.   HAEMATOLOGICA

CCR5 blockage by maraviroc: a potential therapeutic option for metastatic breast cancer

(2018) Asim Pervaiz et al.   CELLULAR ONCOLOGY

Functional role of CCL5/RANTES for HCC progression during chronic liver disease

(2017) Antje Mohs et al.   JOURNAL OF HEPATOLOGY

CSF-1 regulates the function of monocytes in Crohn’s disease patients in remission

(2017) Juan Camilo Nieto et al.   Scientific Reports

Consensus on Stereotactic Body Radiation Therapy for Small-Sized Hepatocellular Carcinoma at the 7th Asia-Pacific Primary Liver Cancer Expert Meeting

(2017) Zhao-Chong Zeng et al.   Liver Cancer

Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients

(2016) Niels Halama et al.   CANCER CELL

SOCS3 is a modulator of human macrophage phagocytosis

(2016) Peter Gordon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Maraviroc decreases CCL8-mediated migration of CCR5+ regulatory T cells and reduces metastatic tumor growth in the lungs

(2016) E. C. Halvorsen et al.   OncoImmunology

Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma

(2015) M Sadeghi et al.   BRITISH JOURNAL OF CANCER

Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma

(2015) Xiaoguang Li et al.   GUT

Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma

(2015) Oscar W.H. Yeung et al.   JOURNAL OF HEPATOLOGY

CCR5 blockage by maraviroc induces cytotoxic and apoptotic effects in colorectal cancer cells

(2015) Asim Pervaiz et al.   MEDICAL ONCOLOGY

Increased drug resistance in breast cancer by tumor-associated macrophages through IL-10/STAT3/bcl-2 signaling pathway

(2015) Cuixia Yang et al.   MEDICAL ONCOLOGY

Myeloid-Derived Cells in Tumors: Effects of Radiation

(2015) Ralph E. Vatner et al.   SEMINARS IN RADIATION ONCOLOGY

The origin and function of tumor-associated macrophages

(2014) Yang Liu et al.   Cellular & Molecular Immunology

The Inflammatory Chemokine CCL5 and Cancer Progression

(2014) Donatella Aldinucci et al.   MEDIATORS OF INFLAMMATION

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer

(2013) J. Xu et al.   CANCER RESEARCH

Clinical significance of macrophage heterogeneity in human malignant tumors

(2013) Yoshihiro Komohara et al.   CANCER SCIENCE

Targeting CCL5 in inflammation

(2013) Rafael Elias Marques et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice

(2013) Neta Barashi et al.   HEPATOLOGY

Maraviroc, a CCR5 Antagonist, Prevents Development of Hepatocellular Carcinoma in a Mouse Model

(2013) Laura Ochoa-Callejero et al.   PLoS One

Stimulation of Hepatoma Cell Invasiveness and Metastatic Potential by Proteins Secreted From Irradiated Nonparenchymal Cells

(2012) Le-Yuan Zhou et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Gefitinib inhibits the cross-talk between mesenchymal stem cells and prostate cancer cells leading to tumor cell proliferation and inhibition of docetaxel activity

(2012) Cinzia Borghese et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation

(2012) H. Qin et al.   JOURNAL OF IMMUNOLOGY

Zoledronic acid blocks the interaction between mesenchymal stem cells and breast cancer cells: implications for adjuvant therapy of breast cancer

(2011) M. Gallo et al.   ANNALS OF ONCOLOGY

Dendritic Cell-Specific ICAM-3-Grabbing Nonintegrin Expression on M2-Polarized and Tumor-Associated Macrophages Is Macrophage-CSF Dependent and Enhanced by Tumor-Derived IL-6 and IL-10

(2011) A. Dominguez-Soto et al.   JOURNAL OF IMMUNOLOGY

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma

(2008) Xiao-Dong Zhu et al.   JOURNAL OF CLINICAL ONCOLOGY