Article
Chemistry, Multidisciplinary
Reena Jatyan, Deepak Kumar Sahel, Prabhjeet Singh, Rajeev Sakhuja, Anupama Mittal, Deepak Chitkara
Summary: In this study, the conjugation of fatty acids with temozolomide improved its anticancer potential against glioblastoma multiforme. The synthesized conjugates showed a stronger inhibitory effect on tumor cells in vitro and improved survival rate in an animal model.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Zhuqing Song, Xiuxian Huang, Jieqiong Wang, Feiyan Cai, Ping Zhao, Fei Yan
Summary: The ultrasound-mediated BBB opening combined with liposomal temozolomide formulation has been successfully applied in the treatment of glioblastoma, significantly inhibiting tumor growth and prolonging animal survival time without significant side effects.
Article
Chemistry, Multidisciplinary
Yan Zou, Yibin Wang, Sen Xu, Yanjie Liu, Jinlong Yin, David B. Lovejoy, Meng Zheng, Xing-Jie Liang, Jong Bae Park, Yuri M. Efremov, Ilya Ulasovand, Bingyang Shi
Summary: A new type of GBM-cell membrane camouflaged and pH-sensitive biomimetic nanoparticles have been developed for combined TMZ and CDDP therapy for GBM. The results show that these nanoparticles can efficiently transport drugs across the blood-brain barrier and specifically target GBM, allowing for controlled release at GBM sites and demonstrating potent anti-GBM effects without obvious side effects.
ADVANCED MATERIALS
(2022)
Article
Environmental Sciences
Ai Mai, Shu-Wen Ye, Jia-Yu Tu, Jun Gao, Zhan-Fang Kang, Qian-Ming Yao, Wei-Jen Ting
Summary: This study demonstrates that thymoquinone (TQ) can effectively cross the blood-brain barrier and has therapeutic potential for the treatment of glioblastoma, especially when used in combination with temozolomide (TMZ).
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiaqi Liu, Yuting Sun, Xianhuang Zeng, Yang Liu, Chaozhi Liu, Ying Zhou, Yueguang Liu, Guihong Sun, Mingxiong Guo
Summary: This study developed artificial vesicles loaded with ANG-TRP-PK1 peptides for targeted therapy of brain tumors. The peptide-loaded vesicles showed better therapeutic effects and reduced side effects compared to traditional drugs in mouse models.
ADVANCED MATERIALS
(2023)
Article
Environmental Sciences
Arabinda Ghosh, Dipanwita Chakraborty, Nobendu Mukerjee, Debabrat Baishya, Sridevi Chigurupati, Shatha Ghazi Felemban, Suliman A. Almahmoud, Mohannad A. Almikhlafi, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Lotfi Aleya, Tapan Behl
Summary: Glioblastoma multiforme is a rare brain disorder that has been extensively researched due to its uncontrolled growth. Target-based virtual screening of drugs using natural phytocompounds, particularly molecules capable of passing through the blood-brain barrier, shows promise in the discovery of new treatments for this disease.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Oncology
Wei-Hao Liao, Ming-Yen Hsiao, Yi Kung, Abel Po-Hao Huang, Wen-Shiang Chen
Summary: GBM is a devastating brain tumor with challenges in drug delivery due to the blood-brain barrier. Research shows that using shockwave (SW), a form of transcranial focused ultrasound, can efficiently open the blood-brain barrier and improve drug delivery, leading to enhanced therapeutic efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Elisa Checa-Chavarria, Eva Rivero-Buceta, Miguel Angel Sanchez Martos, Gema Martinez Navarrete, Cristina Soto-Sanchez, Pablo Botella, Eduardo Fernandez
Summary: This novel therapeutic approach using CPT-ALA shows promising results in targeting GBM cells with improved cytotoxic effects and reduced side effects on healthy tissue. In preclinical studies, CPT-ALA demonstrated significant reduction in intracranial GBM volume without notable toxicity, indicating its potential for improving the success of surgical removal and extending life expectancy by reducing tumor recurrence.
MOLECULAR PHARMACEUTICS
(2021)
Review
Nanoscience & Nanotechnology
Dongdong Liu, Xingliang Dai, Lei Ye, Hua Wang, Haisheng Qian, Hongwei Cheng, Xianwen Wang
Summary: This review summarizes the application and recent progress in nanotechnology-based monotherapies and combination cancer treatment strategies for GBM. These novel treatment methods significantly improve therapeutic efficiency while reducing toxicity. The review also discusses the application of nanotechnology in GBM and identifies the deficiencies of current standard therapy.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Chuanshi He, Zhisheng Wu, Min Zhuang, Xiangyu Li, Shunxu Xue, Songjie Xu, Jinshun Xu, Zhe Wu, Man Lu
Summary: In this study, bionic drug delivery microbubbles were developed and their combination with focused ultrasound showed significant inhibitory effects on glioblastoma. The microbubbles successfully penetrated the blood-brain barrier and effectively inhibited glioblastoma growth, providing a new approach for glioblastoma treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Oncology
Xiangjin Zheng, Qin Tang, Liwen Ren, Jinyi Liu, Wan Li, Weiqi Fu, Jinhua Wang, Guanhua Du
Summary: Glioblastoma multiforme (GBM) is the most aggressive, common, and lethal subtype of malignant brain tumors, current therapies have limited efficacy, driving the search for new treatments, such as cancer immunotherapy and targeted therapies against GSCs.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Shuhan Liu, Ji Liu, Haisong Li, Kuirong Mao, Haorui Wang, Xiandi Meng, Jialiang Wang, Chenxi Wu, Hongmei Chen, Xin Wang, Xiuxiu Cong, Yue Hou, Ye Wang, Ming Wang, Yong-Guang Yang, Tianmeng Sun
Summary: This study develops a novel cationic lipid nanoparticle (LNP) that efficiently delivers siRNA across the blood-brain barrier (BBB) and targets the tumor microenvironment in the brain of mice for immunotherapy of glioblastoma multiforme (GBM). The LNP is effective in delivering siRNA against CD47 and PD-L1 into the cranial GBM in mice, resulting in downregulation of target gene expression and activation of antitumor immunity.
Review
Oncology
Rajneesh Mungur, Jiesheng Zheng, Ben Wang, Xinhua Chen, Renya Zhan, Ying Tong
Summary: The use of LIFU+MBs in drug delivery for glioblastoma has shown to be a safe and effective method, with improved drug uptake and tumor control without causing harm to brain structures.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
M. Anu, Joyal Xavier, A. S. Fathima, Priya Bisht, Krishna Murti, V. Ravichandiran, Nitesh Kumar
Summary: Epigenetic modifications play a crucial role in glioblastoma genes, affecting the development of neural stem cells. Inhibiting PARP can induce cell damage and enhance the effects of chemotherapy and radiotherapy. PARPi is an innovative drug explored for the treatment of glioma, but not all patients respond to it.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Oncology
Rasika Thombre, Griffin Mess, Kelley Kempski M. Leadingham, Shivani Kapoor, Andrew Hersh, Molly Acord, Tarana Kaovasia, Nicholas Theodore, Betty Tyler, Amir Manbachi
Summary: Glioblastoma multiforme (GBM) is a highly resistant brain cancer that is difficult to treat due to the blood-brain barrier (BBB) preventing drug delivery. Focused ultrasound (FUS) can create temporary openings in the BBB, allowing drugs to reach the brain. This systematic review summarizes how FUS-mediated BBB openings can improve drug perfusion in GBM rodent models.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biology
Mohammad Oves, Mohd Ahmar Rauf, Mohammad Aslam, Huda A. Qari, Hana Sonbol, Irfan Ahmad, Gaffar Sarwar Zaman, Mohd Saeed
Summary: The study focused on the synthesis of silver nanoparticles using plant extract as an alternative treatment for drug-resistant infections. The nanoparticles showed significant antibacterial activity against Streptococcus pneumonia and Staphylococcus aureus, as well as promising efficacy against fungal pathogens. Additionally, the nanomaterials exhibited biocompatibility and potential anticancer activities against MDA MB-231 cells.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mohd Ahmar Rauf, Md Tauqir Alam, Mohd Ishtikhar, Nemat Ali, Adel Alghamdi, Abdullah F. AlAsmari
Summary: Protein aggregation and amyloidogenesis are associated with neurodegenerative disorders, but effective treatments are lacking. This study examined the inhibitory effects of biologically synthesized silver nanoparticles on human serum albumin aggregation. The fluorescent nanoparticles showed concentration-dependent inhibition of protein aggregation and exhibited chaperone-like aggregation-inhibition activities in astrocytes.
Article
Chemistry, Multidisciplinary
Wenya He, Xiaozhe Li, Marco Morsch, Muhammad Ismail, Yanjie Liu, Fawad Ur Rehman, Dongya Zhang, Yibin Wang, Meng Zheng, Roger Chung, Yan Zou, Bingyang Shi
Summary: In this study, the researchers discovered that the Mcl-1-specific inhibitor A12 synergizes with ABT to induce potent cell apoptosis in GBM. They also developed a biomimetic nanomedicine that can effectively deliver ABT and A12 to the brain, exhibiting good biocompatibility and efficient blood-brain barrier penetration. This nanomedicine effectively suppressed tumor growth and prolonged the survival time of mice with GBM xenografts without inducing adverse effects.
Article
Engineering, Biomedical
Muhammad Ismail, Wen Yang, Yanfei Li, Tianran Chai, Dongya Zhang, Qiuli Du, Pir Muhammad, Sumaira Hanif, Meng Zheng, Bingyang Shi
Summary: A novel combination drug delivery strategy based on ApoE-functionalized liposomal nanoplatform was presented, which effectively overcame the challenges of the blood-brain barrier and drug resistance, leading to improved survival rates in mice.
Article
Chemistry, Multidisciplinary
Fawad Ur Rehman, Yang Liu, Qingshan Yang, Haoying Yang, Runhan Liu, Dongya Zhang, Pir Muhammad, Yanjie Liu, Sumaira Hanif, Muhammad Ismail, Meng Zheng, Bingyang Shi
Summary: This study explores the use of exosomes secreted by allogeneic bone marrow mesenchymal stem cells as a nanocarrier for glioblastoma therapy. With the decoration of a specific peptide, the nanocarrier exhibits enhanced targeting ability for TMZ resistant GBM. Additionally, the system can deliver targeted siRNA to restore drug sensitivity and achieve treatment of drug-resistant GBM.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Muhammad Ismail, Wen Yang, Yanfei Li, Yibin Wang, Wenya He, Jiefei Wang, Pir Muhammad, Timothy B. Chaston, Fawad Ur Rehman, Meng Zheng, David B. Lovejoy, Bingyang Shi
Summary: The use of biomimetic nanoparticles can overcome the toxicity limitations of copper chelators in the treatment of GBM and enhance the therapeutic effect by increasing selectivity. Pre-loading tumors with copper further improves selectivity. Targeting GBM cells and modulating the apoptotic pathway can effectively suppress GBM growth.
Article
Engineering, Biomedical
Fawad Ur Rehman, Yang Liu, Meng Zheng, Bingyang Shi
Summary: Exosome application is a promising nanotechnology discipline for disease therapy and diagnosis. Due to their natural properties, such as efficient drug delivery and blood-brain barrier traversing ability, exosomes have gained attention in clinical translation for brain diseases treatment.
Review
Biochemistry & Molecular Biology
Zi-Hua Guo, Saadullah Khattak, Mohd Ahmar Rauf, Mohammad Azam Ansari, Mohammad N. Alomary, Sufyan Razak, Chang-Yong Yang, Dong-Dong Wu, Xin-Ying Ji
Summary: Central nervous system disorders, especially neurodegenerative diseases, require a strong scientific response. Nanotechnology-based medicinal approaches provide valuable cargos for treating CNS disorders with greater safety and efficacy. Nanomedicines can overcome the blood-brain barrier and stimulate the immune system for CNS disease amelioration.
Article
Biochemistry & Molecular Biology
Mohd Jameel, Mohd Ahmar Rauf, Mohd Talib Khan, Mohd Kaleemullah Farooqi, Mohd Ashraf Alam, Fouzia Mashkoor, Mohd Shoeb, Changyoon Jeong
Summary: This study investigated the multifunctional properties of Cadmium Sulphide Nanoparticles (CdS NPs) synthesized using a green synthesis method. The CdS NPs showed insecticidal, antibacterial, and anticancer activities. Ingestion of CdS NPs by larvae of Spodoptera litura resulted in dose-dependent changes in biochemical parameters and significant mortality, malformation, and reduced fertility. CdS NPs also exhibited antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus, as well as potent anticancer properties against a pancreatic cancer cell line.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Review
Immunology
Saadullah Khattak, Mohd Ahmar Rauf, Yasir Ali, Muhammad Tufail Yousaf, Zhihui Liu, Dong-Dong Wu, Xin-Ying Ji
Summary: The world is currently dealing with a potential epidemic of monkeypox, a second viral outbreak after COVID-19. While it primarily affects those who live near or in forests, it has recently emerged in African wild mice in the United States. Monkeypox exhibits similar symptoms to smallpox, such as fever, rash, and back pain. Laboratory diagnosis is crucial, although there is no approved treatment for human monkeypox virus infection. Nevertheless, smallpox vaccination can provide protection against the disease, and reducing interaction with sick individuals or animals can help prevent infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mohammad Oves, Mohd Ahmar Rauf, Huda A. A. Qari
Summary: Biogenic silver nanoparticles (BAgNPs) were synthesized using Bougainvillea glabra paper flower extract through green chemistry, where the flower extract acted as a biological reducing agent to convert Ag+ cations to Ag-0 ions. Physical techniques such as UV-visible, SEM, TEM, DLS, XRD, and FTIR were employed to characterize the BAgNPs, revealing spherical to oval nanoparticles with a size range of 10 to 50 nm. The antibacterial properties of the biologically produced BAgNPs were investigated through spectroscopy and microscopic analysis, and their potential mechanism of action was studied through interactions with bacterial strains and mammalian cancer cell systems in vitro. The results suggest that biologically produced nanomaterials, such as BAgNPs, have the potential for biomedical applications in inhibiting bacterial growth and cancer cell growth in culture conditions.
Article
Urology & Nephrology
Laisel Martinez, Miguel G. Rojas, Marwan Tabbara, Simone Pereira-Simon, Nieves Santos Falcon, Mohd Ahmar Rauf, Akshara Challa, Zachary M. Zigmond, Anthony J. Griswold, Juan C. Duque, Roberta M. Lassance-Soares, Omaida C. Velazquez, Loay H. Salman, Roberto I. Vazquez-Padron
Summary: This study investigates the molecular transformation of the human preaccess vein after arteriovenous fistula (AVF) creation and identifies the molecular changes associated with maturation failure. The findings provide a crucial foundation for designing efficacious therapies.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Nanoscience & Nanotechnology
Jiale Ju, Yinghua Wu, Wen He, Lin Zhan, Xuelian Yin, Junfeng Zhang, Yuxi Zhang, Li Qiu, Pir Muhammad, Rui L. Reis, Chenchen Li
Summary: Active ingredients of Chinese medicine show promise in treating gastrointestinal cancer. The use of nanocarriers enhances their effectiveness. This review presents the mechanisms and applications of AIFCM in gastrointestinal cancer, as well as the development of nanocarriers in this field.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Meeting Abstract
Hematology
Filipe F. Stoyell Conti, Miguel Rojas, Zachary Zigmond, Mohd A. Rauf, Laisel Martinez, Roberto I. Vazquez Padron
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Meeting Abstract
Hematology
Laisel Martinez, Miguel Rojas, Marwan Tabbara, Simone Pereira-Simon, Nieves Santos Falcon, Mohd A. Rauf, Zachary Zigmond, Roberto I. Vazquez Padron
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)