Adipose Tissue Hypoxia Correlates with Adipokine Hypomethylation and Vascular Dysfunction

DNA methylation profile of genes involved in inflammation and autoimmunity correlates with vascular function in morbidly obese adults

(2021) Mohamed M. Ali et al.   Epigenetics

HIF1α/TET1 Pathway Mediates Hypoxia-Induced Adipocytokine Promoter Hypomethylation in Human Adipocytes

(2020) Mohamed M. Ali et al.   Cells

Obesity‐associated Hypoxia Contributes to Aberrant Methylation of Genes Implicated in Inflammation and vascular Function

(2020) Mohamed M. Ali et al.   FASEB JOURNAL

Hyperhomocysteinemia and Low Folate and Vitamin B12 Are Associated with Vascular Dysfunction and Impaired Nitric Oxide Sensitivity in Morbidly Obese Patients

(2020) Mohamed Haloul et al.   Nutrients

Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables

(2019) Daniel Castellano-Castillo et al.   Journal of Clinical Medicine

Chemical Inducers of Obesity-Associated Metabolic Stress Activate Inflammation and Reduce Insulin Sensitivity in 3T3-L1 Adipocytes

(2019) I. S. Stafeev et al.   BIOCHEMISTRY-MOSCOW

Analyses of IGFBP2 DNA methylation and mRNA expression in visceral and subcutaneous adipose tissues of obese subjects

(2019) Xiuli Zhang et al.   GROWTH HORMONE & IGF RESEARCH

Low-Fat Diet Designed for Weight Loss But Not Weight Maintenance Improves Nitric Oxide-Dependent Arteriolar Vasodilation in Obese Adults

(2019) Abeer M. Mahmoud et al.   Nutrients

Vitamin D Improves Nitric Oxide-Dependent Vasodilation in Adipose Tissue Arterioles from Bariatric Surgery Patients

(2019) Abeer M. Mahmoud et al.   Nutrients

Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk

(2019) Manuel F. Landecho et al.   Nutrients

An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

(2019) A. K. Ziegler et al.   Scientific Reports

Adipokine dysregulation and adipose tissue inflammation in human obesity

(2018) Xabier Unamuno et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Epigenome-wide association study of adiposity and future risk of obesity-related diseases

(2018) Gianluca Campanella et al.   INTERNATIONAL JOURNAL OF OBESITY

DNA methylation and obesity traits: An epigenome-wide association study. The REGICOR study

(2017) Sergi Sayols-Baixeras et al.   Epigenetics

Novel Epigenetic Controlling of Hypoxia Pathway Related to Overexpression and Promoter Hypomethylation of TET1 and TET2 in RPE Cells

(2017) Mohammad Reza Alivand et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The excessive caloric intake and micronutrient deficiencies related to obesity after a long-term interdisciplinary therapy

(2017) Vanessa Fadanelli Schoenardie Poli et al.   NUTRITION

Hypoxia induces the expression of TET enzymes in HepG2 cells

(2017) Guofu Lin et al.   Oncology Letters

Associations of LEP, CRH, ICAM-1, and LINE-1 methylation, measured in saliva, with waist circumference, body mass index, and percent body fat in mid-childhood

(2017) Jocelyn Dunstan et al.   Clinical Epigenetics

Genome-Wide Methylation Analysis Identifies Specific Epigenetic Marks In Severely Obese Children

(2017) Delphine Fradin et al.   Scientific Reports

A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk

(2016) Xiaoming Lian et al.   CURRENT HYPERTENSION REPORTS

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant Subjects

(2016) Helen M. Lawler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Epigenome-wide association study of body mass index and the adverse outcomes of adiposity

(2016) Simone Wahl et al.   NATURE

Hypoxia Drives Breast Tumor Malignancy through a TET–TNFα–p38–MAPK Signaling Axis

(2015) Min-Zu Wu et al.   CANCER RESEARCH

Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood

(2015) R C Huang et al.   Epigenetics

Genome-wide screen of DNA methylation identifies novel markers in childhood obesity

(2015) Xu Ding et al.   GENE

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

(2015) Kuppusamy Balamurugan   INTERNATIONAL JOURNAL OF CANCER

Genomic DNA Hypomethylation Is Associated with Neural Tube Defects Induced by Methotrexate Inhibition of Folate Metabolism

(2015) Xiuwei Wang et al.   PLoS One

Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance

(2015) A. Young Kim et al.   Nature Communications

The Hypoxia-Inducible Factor Pathway in Adipocytes: The Role of HIF-2 in Adipose Inflammation and Hypertrophic Cardiomyopathy

(2015) Qun Lin et al.   Frontiers in Endocrinology

LINE-1 Hypomethylation is Associated with the Risk of Coronary Heart Disease in Chinese Population

(2014) Li Wei et al.   Arquivos Brasileiros de Cardiologia

LINE-1 Methylation is Associated with an Increased Risk of Ischemic Stroke in Men

(2014) Reuy-Tay Lin et al.   CURRENT NEUROVASCULAR RESEARCH

The Effect of Hypoxia Preconditioning on DNA Methyltransferase and PP1γ in Hippocampus of Hypoxia Preconditioned Mice

(2014) Shu Zhang et al.   HIGH ALTITUDE MEDICINE & BIOLOGY

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

(2013) S. Fujisaka et al.   DIABETOLOGIA

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Hypoxia Induces Genomic DNA Demethylation through the Activation of HIF-1  and Transcriptional Upregulation of MAT2A in Hepatoma Cells

(2011) Q. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Epigenetics and lifestyle

(2011) Jorge Alejandro Alegría-Torres et al.   Epigenomics

Ischemic Heart Disease and Stroke in Relation to Blood DNA Methylation

(2010) Andrea Baccarelli et al.   EPIDEMIOLOGY

Epigenetics meets endocrinology

(2010) X. Zhang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vitamin D Deficiency and Risk for Cardiovascular Disease

(2009) Suzanne E. Judd et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Homocysteine Level and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis

(2009) Linda L. Humphrey et al.   MAYO CLINIC PROCEEDINGS

Emerging role of adipose tissue hypoxia in obesity and insulin resistance

(2008) J Ye   INTERNATIONAL JOURNAL OF OBESITY

Epigenetics and obesity

(2008) Reinhard Stöger   PHARMACOGENOMICS

Alcohol increases homocysteine and reduces B vitamin concentration in healthy male volunteers--a randomized, crossover intervention study

(2008) A. Gibson et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE