HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators

N6-Methyladenosine Modification of Hepatitis B and C Viral RNAs Attenuates Host Innate Immunity via RIG-I Signaling

(2020) Geon-Woo Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Virus Regulatory Insights Into Avian N6-Methyladenosine (m6A) Machinery

(2020) Mahmoud Bayoumi et al.   Frontiers in Cell and Developmental Biology

HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication

(2019) Nagaraja Tirumuru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colocalization of m6A and G-Quadruplex-Forming Sequences in Viral RNA (HIV, Zika, Hepatitis B, and SV40) Suggests Topological Control of Adenosine N6-Methylation

(2019) Aaron M. Fleming et al.   ACS Central Science

Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site

(2019) Simona Selberg et al.   Cell Reports

LC/MS analysis and deep sequencing reveal the accurate RNA composition in the HIV-1 virion

(2019) Anna Šimonová et al.   Scientific Reports

Regulation of Viral Infection by the RNA Modification N6-methyladenosine

(2019) Graham D. Williams et al.   Annual Review of Virology

Viral N6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

(2019) Miaoge Xue et al.   Nature Communications

Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection

(2019) Nandan S. Gokhale et al.   MOLECULAR CELL

Why and where an HIV cure is needed and how it might be achieved

(2019) Thumbi Ndung’u et al.   NATURE

Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV

(2018) Youry Kim et al.   Cell Host & Microbe

N6-methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

(2018) Wuxun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′-3′ exoribonuclease XRN1

(2018) Jens Kretschmer et al.   RNA

Reading m 6 A in the Transcriptome: m 6 A-Binding Proteins

(2018) Deepak P. Patil et al.   TRENDS IN CELL BIOLOGY

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents

(2018) Matthew D. Marsden et al.   VIROLOGY

N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection

(2018) Charles R. Hesser et al.   PLoS Pathogens

Emerging Roles of N6-Methyladenosine on HIV-1 RNA Metabolism and Viral Replication

(2018) Sebastián Riquelme-Barrios et al.   Frontiers in Microbiology

N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle

(2018) Hasan Imam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the RNA methyltransferase domain of METTL16

(2018) Agnieszka Ruszkowska et al.   Scientific Reports

m6A: Widespread regulatory control in virus replication

(2018) Oliver Manners et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RNA modifications go viral

(2017) Nandan S. Gokhale et al.   PLoS Pathogens

Posttranscriptional m 6 A Editing of HIV-1 mRNAs Enhances Viral Gene Expression

(2016) Edward M. Kennedy et al.   Cell Host & Microbe

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2016) Xiang Wang et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA

(2016) Jessica A. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression

(2016) Nagaraja Tirumuru et al.   eLife

Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells

(2016) Gianluigi Lichinchi et al.   Nature Microbiology

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds

(2014) Muthusamy Venkatraj et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies

(2013) Hai-Qiu Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

The M230L Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutation in HIV-1 Reverse Transcriptase Impairs Enzymatic Function and Viral Replicative Capacity

(2010) H. T. Xu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HIV reservoirs, latency, and reactivation: Prospects for eradication

(2009) Viktor Dahl et al.   ANTIVIRAL RESEARCH