Advances in cell surface glycoengineering reveal biological function

Pneumococcal Neuraminidase Substrates Identified through Comparative Proteomics Enabled by Chemoselective Labeling

(2016) Janet E. McCombs et al.   BIOCONJUGATE CHEMISTRY

Selective Exo-Enzymatic Labeling Detects Increased Cell Surface Sialoglycoprotein Expression upon Megakaryocytic Differentiation

(2016) Seok-Ho Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal Chemistry

(2015) Paresh Agarwal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glycocalyx Engineering with a Recycling Glycopolymer that Increases Cell Survival In Vivo

(2015) Elliot C. Woods et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolic Remodeling of Cell-Surface Sialic Acids: Principles, Applications, and Recent Advances

(2015) Bo Cheng et al.   CHEMBIOCHEM

Cell surface glycan engineering of neural stem cells augments neurotropism and improves recovery in a murine model of multiple sclerosis

(2015) Jasmeen S Merzaban et al.   GLYCOBIOLOGY

Cellular metabolism of unnatural sialic acid precursors

(2015) Nam D. Pham et al.   GLYCOCONJUGATE JOURNAL

Mouse Siglec-1 Mediatestrans-Infection of Surface-bound Murine Leukemia Virus in a Sialic AcidN-Acyl Side Chain-dependent Manner

(2015) Elina Erikson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemically tunable mucin chimeras assembled on living cells

(2015) Jessica R. Kramer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fucosylation and protein glycosylation create functional receptors for cholera toxin

(2015) Amberlyn M Wands et al.   eLife

The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice

(2015) John D. Belcher et al.   PLoS One

Long-Lived Engineering of Glycans to Direct Stem Cell Fate

(2014) Abigail Pulsipher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeted Imaging and Proteomic Analysis of Tumor-Associated Glycans in Living Animals

(2014) Ran Xie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanding the scope of cyclopropene reporters for the detection of metabolically engineered glycoproteins by Diels–Alder reactions

(2014) Anne-Katrin Späte et al.   Beilstein Journal of Organic Chemistry

Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering

(2014) Anne-Katrin Späte et al.   CHEMISTRY-A EUROPEAN JOURNAL

Systemic Blockade of Sialylation in Mice with a Global Inhibitor of Sialyltransferases

(2014) Matthew S. Macauley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycocalyx Remodeling with Proteoglycan Mimetics Promotes Neural Specification in Embryonic Stem Cells

(2014) Mia L. Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directing Neuronal Signaling through Cell-Surface Glycan Engineering

(2014) Abigail Pulsipher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improved cyclopropene reporters for probing protein glycosylation

(2014) David M. Patterson et al.   Molecular BioSystems

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Two-Color Glycan Labeling of Live Cells by a Combination of Diels-Alder and Click Chemistry

(2013) Andrea Niederwieser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Exo-Enzymatic Labeling of N-Glycans on the Surface of Living Cells by Recombinant ST6Gal I

(2013) Ngalle Eric Mbua et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter

(2013) Anne-Katrin Späte et al.   BIOCONJUGATE CHEMISTRY

Bifunctional Unnatural Sialic Acids for Dual Metabolic Labeling of Cell-Surface Sialylated Glycans

(2013) Lianshun Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of orally active inhibitors of protein and cellular fucosylation

(2013) N. M. Okeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycan-Specific Metabolic Oligosaccharide Engineering of C7-Substituted Sialic Acids

(2012) Heinz Möller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation

(2012) Leslie A. Bateman et al.   CHEMICAL COMMUNICATIONS

Glycoproteomics enabled by tagging sialic acid- or galactose-terminated glycans

(2012) T. N. C. Ramya et al.   GLYCOBIOLOGY

Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers

(2012) Jean-Luc Chaubard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized Cyclopropenes As Bioorthogonal Chemical Reporters

(2012) David M. Patterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell-Selective Metabolic Glycan Labeling Based on Ligand-Targeted Liposomes

(2012) Ran Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

(2012) Cory D Rillahan et al.   Nature Chemical Biology

Tracking N-Acetyllactosamine on Cell-Surface Glycans In Vivo

(2011) Tianqing Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modified GM3 gangliosides produced by metabolic oligosaccharide engineering

(2011) Chad M. Whitman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metabolic oligosaccharide engineering with N-Acyl functionalized ManNAc analogs: Cytotoxicity, metabolic flux, and glycan-display considerations

(2011) Ruben T. Almaraz et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1

(2011) B. W. Zaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic cross-talk allows labeling of O-linked  -N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway

(2011) M. Boyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Strategy for the Selective Imaging of Glycans Using Caged Metabolic Precursors

(2010) Pamela V. Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Situ transLigands of CD22 Identified by Glycan-Protein Photocross-linking-enabled Proteomics

(2010) T. N. C. Ramya et al.   MOLECULAR & CELLULAR PROTEOMICS

Metabolically incorporated photocrosslinking sialic acid covalently captures a ganglioside–protein complex

(2010) Michelle R. Bond et al.   Molecular BioSystems

Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars

(2009) Pamela V. Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins

(2009) D. D. Marathe et al.   BLOOD

High-efficiency labeling of sialylated glycoproteins on living cells

(2009) Ying Zeng et al.   NATURE METHODS

Photoactivatable Crosslinking Sugars for Capturing Glycoprotein Interactions

(2008) Yoshihito Tanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

(2008) Robert Sackstein et al.   NATURE MEDICINE