Article
Oncology
Lina Marie, Dina Braik, Nayef Abdel-Razeq, Hala Abu-Fares, Ahmad Al-Thunaibat, Hikmat Abdel-Razeq
Summary: Breast cancer with de novo bone-only metastasis has distinct clinical features and prognosis compared to subsequent bone-only metastasis. Patients with de novo bone-only metastasis have shorter overall survival.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Ying Ren, Shicheng Wang, Bo Wu, Zhan Wang
Summary: This study aims to uncover the clinicopathological features and identify prognostic risk factors among patients with pancreatic cancer bone metastasis (PCBM). The results show that age, pathological type, chemotherapy, liver metastasis, lung metastasis, and marital status are independent prognostic factors for PCBM patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Zhan Wang, Haiyu Shao, Qiang Xu, Yongguang Wang, Yaojing Ma, Diarra Mohamed Diaty, Jiahao Zhang, Zhaoming Ye
Summary: This study aimed to identify independent survival predictors among young women with breast cancer bone metastasis (BCBM) and develop prognostic nomograms for individualized survival evaluation.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yingru Xu, Shuxia Zhang, Xinyi Liao, Man Li, Suwen Chen, Xincheng Li, Xingui Wu, Meisongzhu Yang, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Mudan Huang, Libing Song, Jun Li
Summary: A novel circRNA, circIKBKB, was significantly upregulated in bone-metastatic breast cancer tissues. CircIKBKB enhanced the ability of breast cancer cells to induce bone pre-metastatic niche formation by promoting osteoclastogenesis and activating the NF-kappa B pathway. Inhibiting circIKBKB expression effectively suppressed breast cancer bone metastasis, indicating a potential therapeutic strategy.
Article
Cell Biology
Maria Belen Giorello, Leandro Marcelo Martinez, Francisco Raul Borzone, Maria del Rosario Padin, Maria Florencia Mora, Ina Sevic, Laura Alaniz, Maria de Lujan Calcagno, Hernan Garcia-Rivello, Alejandra Wernicke, Vivian Labovsky, Norma Alejandra Chasseing
Summary: This study found that high CD105 expression in cancer-associated fibroblasts in early breast cancer patients is significantly associated with the occurrence of metastasis, particularly bone metastasis. High CD105 expression is also associated with shorter metastasis-free survival, bone metastasis-free survival, and overall survival. CD105 expression is an independent prognostic factor for metastasis-free survival, bone metastasis-free survival, and overall survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Jin-Jin Li, Shuai Wang, Zhong-Ning Guan, Jin-Xi Zhang, Ri-Xin Zhan, Jian-Long Zhu
Summary: In this study, DEGs associated with BRCA bone metastasis were detected, and AGR2 was identified as the most important prognostic biomarker, which may play a vital role in cancer progression by regulating the IL-17 and NF-kB signaling pathways.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Oncology
Xiaoshuang Lyu, Bin Luo
Summary: This study analyzed the clinical features and prognostic factors for HER2-positive breast cancer patients with bone metastases, identifying seven prognostic factors for predicting cancer-specific survival. A nomogram was constructed for accurate survival prediction in these patients.
Article
Multidisciplinary Sciences
Aaron E. Chiou, Chuang Liu, Ines Moreno-Jimenez, Tengteng Tang, Wolfgang Wagermaier, Mason N. Dean, Claudia Fischbach, Peter Fratzl
Summary: Factors secreted by breast cancer may promote disturbed bone growth before metastasis, potentially affecting the initial seeding of tumor cells.
Article
Endocrinology & Metabolism
Yu Min, Xiaoman Liu, Daixing Hu, Hang Chen, Jialin Chen, Ke Xiang, Guobing Yin, Yuling Han, Yang Feng, Haojun Luo
Summary: Breast cancer patients with no lymph node metastasis but distant metastasis present specific clinicopathological characteristics that are associated with the risk of distant metastasis and prognosis, including factors such as age, tumor size, race, tumor location, grade, and histology. A novel nomogram for predicting 1-, 3-, and 5- year CSS in T1-3N0M1 patients has been established and validated, which could assist clinicians in better stratifying patients and implementing relatively aggressive management.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Claire L. Ihle, Sabrina J. Wright-Hobart, Philip Owens
Summary: The survival rate of breast cancer patients has improved, but metastatic breast cancer still causes high mortality. Metastasis mainly occurs in the bone, and current treatment methods focus on palliative care and slowing down the progression. Recent advances in molecularly targeted agents have made breakthroughs in the treatment of metastatic breast cancer, but immunotherapies have not been fully applied in estrogen receptor-positive tumors. Therapeutic approaches targeting the bone microenvironment of metastatic breast cancer have potential applications in other bone-resident cancers.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Alessandro Fulgenzi, Anita Ferraretto
Summary: Bone metastasis is a severe complication of common cancers like breast and prostate cancer, reducing survival rates and quality of life. Following a Mediterranean diet can prevent cancer and improve patient health, potentially impacting the spread of cancer to the bones.
Review
Health Care Sciences & Services
Lei Yi, Kai Ai, Xurui Li, Zhihong Li, Yuan Li
Summary: Bladder cancer is a common and deadly malignancy worldwide. Metastasis to the bone is a major concern for patients, with a one-year survival rate of only 21%. The mechanism of bladder cancer metastasis to the bone is not fully understood, and further research is required. Different imaging mechanisms have limitations in diagnosing bone metastasis, and treatment options include chemotherapy, immunotherapy, targeted therapy, and surgery, with the goal of improving survival and quality of life.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Oncology
Xupeng Chai, Eloy Yinwang, Zenan Wang, Zhan Wang, Yucheng Xue, Binghao Li, Hao Zhou, Wenkan Zhang, Shengdong Wang, Yongxing Zhang, Hengyuan Li, Haochen Mou, Lingling Sun, Hao Qu, Fangqian Wang, Zengjie Zhang, Tao Chen, Zhaoming Ye
Summary: This review summarizes recent clinical research studies on biomarkers detected in samples obtained from patients with lung cancer bone metastasis, including various markers related to bone metabolism and their prognostic value.
FRONTIERS IN ONCOLOGY
(2021)
Review
Genetics & Heredity
Jingyao Cui, Haoran Chen, Kaiwen Zhang, Xin Li
Summary: Wnt pathway plays a crucial role in cancer bone metastasis and targeted therapeutic strategies have shown promise. Current progress includes research on pharmacological Wnt modulators against breast cancer bone metastasis and exploration of emerging therapeutic strategies based on Wnt pathway-related targets, providing new ideas for the development of Wnt-based intervention strategies in the future.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Anita Ferraretto, Giovanni Lombardi
Summary: Bone metastases are a major issue in the progression of breast cancer, posing a significant treatment challenge. Interleukin-11 plays a key role in bone metastasis and could be a candidate for anti-metastatic therapy. Further research is needed to understand the contribution of different cytokines in breast cancer progression and develop effective therapeutic strategies.
Meeting Abstract
Oncology
Caio Max Sao Pedro Rocha Lima, Greg Yothers, Samuel A. Jacobs, Hanna Kelly Sanoff, Deirdre Jill Cohen, Katherine A. Guthrie, Norah Lynn Henry, Patricia A. Ganz, Scott Kopetz, Peter C. Lucas, Charles David Blanke, Norman Wolmark, Howard S. Hochster, Thomas J. George, Michael J. Overman
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Jia-Ying Lloyd Lee, Prasanna Ekambaram, Neil M. Carleton, Dong Hu, Linda R. Klei, Zongyou Cai, Max Myers, Nathaniel E. Hubel, Lidija Covic, Sameer Agnihotri, Daniel Krappmann, Frederic Bornancin, Adrian Lee, Steffi Oesterreich, Linda M. McAllister-Lucas, Peter C. Lucas
Summary: MALT1 is the effector protein in the CARMA/Bcl10/MALT1 inflammatory signaling pathways, playing a key role in EMT in immune cells and solid tumors, particularly in TNBC, where its signaling blockade can partially reverse EMT.
MOLECULAR CANCER RESEARCH
(2022)
Meeting Abstract
Oncology
Ashuvinee Elangovan, Emily A. Bossart, Ahmed Basudan, Nilgun Tasdemir, Osama Shiraz Shah, Kai Ding, Carolin Meier, Tanya Heim, Lori Miller, Tiantong Liu, Shannon L. Puhalla, Grzegorz Gurda, Peter C. Lucas, Priscilla F. McAuliffe, Jennifer M. Atkinson, Adrian V. Lee, Steffi Oesterreich
Meeting Abstract
Oncology
Katherine L. Pogue-Geile, Ying Wang, Huichen Feng, Corey Lipchick, Patrick Gavin, Rim S. Kim, Reena S. Cecchini, Samuel A. Jacobs, Ashok Srinivasan, Sandra M. Swain, Eleftherios Mamounas, Charles E. Geyer, Priya Rastogi, Peter C. Lucas, C. Kent Osborne, Soonmyung Paik, Norman Wolmark, Mothaffar F. Rimawi
Article
Oncology
Azadeh Nasrazadani, Yujia Li, Yusi Fang, Osama Shah, Jennifer M. Atkinson, Joanna S. S. Lee, Priscilla F. McAuliffe, Rohit Bhargava, George Tseng, Adrian V. V. Lee, Peter C. Lucas, Steffi Oesterreich, Norman Wolmark
Summary: This study describes the clinicopathologic characteristics of mixed invasive ductal lobular carcinoma (mDLC) and finds that mDLC is clinically more similar to invasive lobular carcinoma (ILC) than invasive ductal carcinoma (IDC). Successful breast-conserving surgery rates after neoadjuvant chemotherapy are higher in mDLC patients compared to ILC patients. The metastatic patterns of mDLC show characteristics of both IDC and ILC.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Carsten Denkert, Chiara Lambertini, Peter A. Fasching, Katherine L. Pogue-Geile, Max S. Mano, Michael Untch, Norman Wolmark, Chiun-Sheng Huang, Sibylle Loibl, Eleftherios P. Mamounas, Charles E. Geyer Jr, Peter C. Lucas, Thomas Boulet, Chunyan Song, Gail D. Lewis, Malgorzata Nowicka, Sanne de Haas, Mark Basik
Summary: In patients with residual invasive breast cancer, T-DM1 reduces the risk of disease recurrence or death compared to trastuzumab. The efficacy of T-DM1 is independent of HER2 expression level and immune activation.
CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Sayali S. Onkar, Neil M. Carleton, Peter C. Lucas, Tullia C. Bruno, Adrian V. Lee, Dario A. A. Vignali, Steffi Oesterreich
Summary: Breast cancer is a diverse disease with different subtypes, and recent advances have provided new insights into the complex interactions between tumor and immune cells. While immunotherapy has shown limited promise for breast cancer, this review aims to identify opportunities for tailored immunotherapy agents based on the specific features of each breast cancer subtype.
Correction
Oncology
Sayali Onkar, Jian Cui, Jian Zou, Carly Cardello, Anthony R. Cillo, Mostofa Rafid Uddin, April Sagan, Marion Joy, Hatice U. Osmanbeyoglu, Katherine L. Pogue-Geile, Priscilla F. McAuliffe, Peter C. Lucas, George C. Tseng, Adrian V. Lee, Tullia C. Bruno, Steffi Oesterreich, Dario A. A. Vignali
Article
Oncology
Sayali Onkar, Jian Cui, Jian Zou, Carly Cardello, Anthony R. Cillo, Mostofa Rafid Uddin, April Sagan, Marion Joy, Hatice U. Osmanbeyoglu, Katherine L. Pogue-Geile, Priscilla F. McAuliffe, Peter C. Lucas, George C. Tseng, Adrian V. V. Lee, Tullia C. Bruno, Steffi Oesterreich, Dario A. A. Vignali
Summary: Using single-cell and high-dimensional profiling, this study investigates the immune biology of estrogen receptor-positive (ER+) breast cancer in women with invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC). The results show that macrophages, rather than T cells, are the dominant immune cells infiltrating the tumor bed in both IDC and ILC. Furthermore, an interplay between macrophages and T cells is associated with longer disease-free survival in IDC but not ILC.
Meeting Abstract
Endocrinology & Metabolism
David M. Gau, Quanhong Sun, Pooja Chawla, Ian Elder, Marion Joy, Peter C. Lucas, David N. Boone, Deborah L. Galson, Partha Roy
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Meeting Abstract
Oncology
Saigopalakrishna S. Yerneni, Juliana H. Azambuja, Peter C. Lucas, Linda McAllister-Lucas, Kathryn A. Whitehead
Meeting Abstract
Oncology
Juliana Hofstatter Azambuja, Saigopalakrishna S. Yerneni, Gabriela N. Debom, Lisa M. Maurer, Hannah E. Butterfield, Linda R. Klei, Gary Kohanbash, Peter C. Lucas, Linda M. McAllister-Lucas
Meeting Abstract
Oncology
Maria Beecher, Dong Hu, Linda Klei, Jack Little, Linda M. McAllister-Lucas, Peter C. Lucas
Meeting Abstract
Oncology
Katherine L. Pogue-Geile, Sai K. Maley, Rim S. Kim, Ying Wang, Roberto Salgado, Corey Lipchik, Huichen Feng, Reena S. Cecchini, Samuel A. Jacobs, Ashok Srinivasan, Eleftherios Terry Mamounas, Charles E. Geyer, Priya Rastogi, C. Kent Osborne, Soonmyung Paik, Norman Wolmark, Peter C. Lucas, Mothaffar Rimawi
Meeting Abstract
Oncology
Osama Shiraz Shah, Azadeh Nasrazadani, Jennifer M. Atkinson, Celina Kleer, Priscilla F. McAuliffe, Rohit Bhargava, Jorge Reis-Filho, Peter C. Lucas, Adrian V. Lee, Steffi Oesterreich