Article
Oncology
Joan Font-Diaz, Alba Jimenez-Panizo, Carme Caelles, Maria dM Vivanco, Paloma Perez, Ana Aranda, Eva Estebanez-Perpina, Antonio Castrillo, Mercedes Ricote, Annabel F. Valledor
Summary: Nuclear receptors are important transcription factors that regulate gene expression, influencing cell proliferation, differentiation, and apoptosis, and are significant for cancer intervention.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alessandro Zucchi, Francesco Claps, Antonio Luigi Pastore, Alessandro Perotti, Andrea Biagini, Luana Sallicandro, Rosaria Gentile, Concetta Caglioti, Federico Palazzetti, Bernard Fioretti
Summary: Bladder cancer is a common urinary system tumor, especially in males. Surgery and intravesical instillations can eliminate it, but recurrences and progression are frequent. Therefore, adjuvant therapy should be considered. Resveratrol has shown potential as an adjuvant therapy for bladder cancer, with anti-proliferative effects at high concentrations and anti-angiogenic action at low concentrations. This review examines the standard therapeutic approach to bladder cancer, preclinical studies on resveratrol in bladder cancer xenotransplantation models, and discusses molecular signals, particularly the STAT3 pathway and angiogenic growth factor modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ning Huang, Lei Peng, Jiaping Yang, Jinqian Li, Sheng Zhang, Mingjuan Sun
Summary: This study found that FAM111B gene is overexpressed in bladder cancer and is associated with lymphatic metastasis and reduced overall survival. Knockdown of FAM111B gene can inhibit cell proliferation and migration, induce apoptosis, and suppress tumor growth.
Review
Oncology
Yong Xia, Ruijiao Chen, Guangzhen Lu, Changlin Li, Sen Lian, Taek-Won Kang, Young Do Jung
Summary: Phytochemicals derived from plants have shown promising anticancer activities, some of which have been developed into first-line anticancer drugs. However, their specific applications in bladder cancer therapy are limited. Summarizing the mechanism of action of phytochemicals in bladder cancer could contribute to the development of new anticancer drugs and treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Alakananda Basu
Summary: The interplay between apoptosis and senescence is crucial in cancer development, and targeting the Bcl-2 family proteins could be a promising strategy for cancer therapy. Therapy-induced senescence (TIS), induced by chemotherapeutic agents, has been controversial in its effect on therapeutic outcome. Clearance of senescent cells and overcoming their pro-survival mechanisms are important challenges in cancer treatment. This review article discusses recent literature on the role of the Bcl-2 family proteins in apoptosis and senescence, and the progress and limitations in targeting them for cancer therapy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghamir
Summary: This study demonstrates that MSC-exosomes have certain anti-tumor effects on prostate, bladder, and kidney cancer cells. These effects are mainly achieved by inducing apoptosis and inhibiting cancer cell proliferation.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Linlin Zhang, Zaiming Lu, Xiangxuan Zhao
Summary: Apoptosis deficiency is a crucial feature in neoplastic diseases, with the Bcl-2 family of proteins playing a decisive role in regulating apoptosis. Studies have shown that hyperactivation of Bcl-2 anti-apoptotic effects is associated with cancer occurrence and resistance to therapy, making targeting Bcl-2 inactivation a promising route for cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Yang Dong, Wei-ming Ma, Zhen-duo Shi, Zhi-guo Zhang, Jia-he Zhou, Yang Li, Shao-qi Zhang, Kun Pang, Bi-bo Li, Wen-da Zhang, Tao Fan, Guang-yuan Zhu, Liang Xue, Rui Li, Ying Liu, Lin Hao, Cong-hui Han
Summary: Bladder urothelial carcinoma (BC) is a deadly malignancy, and Neuropilin-1 (NRP1) has been found to be highly expressed in BC tissues and cells. Knockdown of NRP1 promotes apoptosis and inhibits proliferation, angiogenesis, migration, and invasion of BC cells, potentially serving as a new therapeutic target for BC treatment. Additionally, NRP1 affects various biological functions through MAPK signaling and cancer pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jin Zhu, Peibo Qin, Cheng Cao, Guangcheng Dai, Lijun Xu, Dongrong Yang
Summary: Inhibiting TR4 enhanced sensitivity to docetaxel in PCa, while downregulating miR-145 expression by TR4 inhibited its direct target OCT4, leading to chemoresistance.
Article
Biochemistry & Molecular Biology
Chao-Yu Hsu, Wei-Ting Yang, Ju-Hwa Lin, Chien-Hsing Lu, Kai-Cheng Hu, Tsuo-Hung Lan, Chia-Che Chang
Summary: Sertindole has been found to have antiproliferative effects on bladder cancer cells by inhibiting the STAT3/BCL-xL signaling pathway, suggesting its potential as a therapeutic strategy for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Anna Kawiak, Anna Kostecka
Summary: Breast cancer is the leading cause of cancer-related deaths in women, with estrogen receptor-positive breast cancer accounting for two-thirds of cases. Endocrine therapy has shown benefits in treating estrogen receptor-positive breast cancer, but resistance to therapy remains a challenge. The Bcl-2 family of proteins plays a crucial role in regulating cell survival or death, particularly in resistance to endocrine therapy. Advances have been made in targeting the Bcl-2 family proteins, and their application in estrogen receptor-positive breast cancer has been explored.
Review
Oncology
Shanna Qian, Zhong Wei, Wanting Yang, Jinling Huang, Yinfeng Yang, Jinghui Wang
Summary: Apoptosis, a crucial biological process, plays a central role in cancer development and traditional cytotoxic therapies. The study of BCL-2 family proteins in regulating apoptosis and the development of anticancer drugs targeting BCL-2 anti-apoptotic proteins has gained increasing attention, showing great potential in cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vijay Kumar Veena, Ahana Roy Choudhury, Adhikesavan Harikrishnan
Summary: A newly synthesized 4H-chromene carbonitrile derivative was found to strongly interact with Bcl-2 and Bax proteins, leading to downregulation of these antiapoptotic proteins and induction of apoptosis in leukemic cells. The compound showed potential as an inhibitor of antiapoptotic machinery and demonstrated selective inhibition towards certain target proteins essential for cancer cell survival.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Tiffany Tate, Tina Xiang, Sarah E. Wobker, Mi Zhou, Xiao Chen, Hyunwoo Kim, Ekatherina Batourina, Chyuan-Sheng Lin, William Y. Kim, Chao Lu, James M. Mckiernan, Cathy Lee Mendelsohn
Summary: The differential expression of PPARg in bladder cancer subtypes plays a crucial role in tumor formation and progression. The activation of Pparg in basal bladder cells can prevent tumor formation but injury-induced differentiation of these cells into luminal cells can lead to tumor development. Understanding the molecular mechanisms behind subtype transition provides important insights for the diagnosis and treatment of bladder cancer.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Xu Zhang, Hao Xiong, Yong Zhao, Shengqiang Lin, Xiang Huang, Cheng Lin, Shihui Mao, Demin Chen
Summary: This research identifies the circLONP2/miR-584-5p/YAP1 axis as a novel regulatory module in the progression of bladder cancer. The study shows that circLONP2 plays an oncogenic role by regulating the miR-584-5p/YAP1 axis, and targeting this interaction could be a potential strategy for treating bladder cancer.