Article
Biochemistry & Molecular Biology
Wei-Ting Chang, Chia-Chun Wu, I-Chuang Liao, Yu-Wen Lin, Yi-Chen Chen, Chung-Han Ho, Wei-Chieh Lee, You-Cheng Lin, Zhih-Cherng Chen, Jhih-Yuan Shih, Nan-Chun Wu, Wei-Chih Kan
Summary: This study found that breast cancer patients receiving Doxorubicin treatment have a significantly higher risk of renal failure. Another experiment showed that Dapagliflozin can mitigate Doxorubicin-induced nephrotoxicity. Therefore, Dapagliflozin may have the potential to prevent nephrotoxicity in cancer patients undergoing Doxorubicin treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Toxicology
Wei-Ting Chang, Jhih-Yuan Shih, Yu-Wen Lin, Zhih-Cherng Chen, Wei-Chih Kan, Tsung-Hsien Lin, Chon-Seng Hong
Summary: This study found that DAPA has a protective effect against Dox-induced cardiotoxicity and demonstrated the important role of STAT3 in this process. DAPA improves cardiac function by reducing cardiac fibrosis and inhibiting cell apoptosis and reactive oxygen species generation. Furthermore, the study also showed that DAPA can restore Dox-suppressed STAT3 expression.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Beihua Xu, Zhongpeng Ding, Ying Hu, Ting Zhang, Senlin Shi, Guangmao Yu, Xuchen Qi
Summary: In this study, fullerenol-modified micelles were prepared with DSPE-PEG-C60 as a carrier for delivering doxorubicin (DOX) with enhanced efficacy and safety in vivo. The results showed that DOX could be successfully loaded into the micelles with suitable particle size and encapsulation efficiency. The DSPE-PEG-C60 micelles exhibited lower cytotoxicity on normal cell lines compared to free DOX and DSPE-PEG micelles. Additionally, DSPE-PEG-C60 showed a protective role in doxorubicin-induced cardiomyocyte damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thomas Gabriel Mhone, Ming-Cheng Chen, Chia-Hua Kuo, Tzu-Ching Shih, Chung-Min Yeh, Tso-Fu Wang, Ray-Jade Chen, Yu-Chun Chang, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study aimed to explore a tumor suppressive compound that can enhance the efficacy of Gefitinib treatment in lung cancer. Through in vitro and in vivo experiments, it was found that the combination of Daidzein and Gefitinib synergistically induced apoptosis and cell cycle arrest, effectively inhibiting lung cancer growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Tanushree Das, Snehasis Mishra, Sayoni Nag, Krishna Das Saha
Summary: In this study, green gold nanoparticles (BTE-GNPs) prepared from black tea extract were used to examine the chemosensitivity of colon cancer cells (HCT116) to doxorubicin. The results showed that BTE-GNPs significantly enhanced the cytotoxic effect of doxorubicin in HCT116 cells, leading to apoptosis through a ROS-dependent pathway.
Article
Cell Biology
Cheng Qin, Yuanyang Wang, Bangbo Zhao, Zeru Li, Tianyu Li, Xiaoying Yang, Yutong Zhao, Weibin Wang
Summary: Pancreatic cancer is a lethal disease with low survival rate, and chemotherapy resistance is common. Mitochondria, as the energy source in cancer cells, play a role in chemoresistance. STOML2, located in the inner membrane of mitochondria, is highly expressed in cancer cells. This study found that high STOML2 expression correlated with improved survival in patients with pancreatic cancer. STOML2 inhibited cell proliferation and chemoresistance in pancreatic cancer cells, and was associated with mitochondrial mass and mitophagy. STOML2 stabilized PARL and prevented gemcitabine-induced PINK1-dependent mitophagy, suggesting that targeting STOML2 might enhance gemcitabine therapy in the future.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Bradley Stockard, Neha Bhise, Miyoung Shin, Joy Guingab-Cagmat, Timothy J. Garrett, Stanley Pounds, Jatinder K. Lamba
Summary: The study reveals that metabolic differences in AML cells contribute to drug resistance and may potentially serve as predictive biomarkers for chemosensitivity to various anti-leukemic drugs. These results provide an opportunity to further explore these metabolites in patient samples for association with clinical response.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Panpan Feng, Yue Yang, Neng Liu, Sihang Wang
Summary: This article investigates the cardiotoxicity of doxorubicin and the protective effect of baicalein, focusing on the role of the TLR4/IκBα/NF-κB signaling pathway and inflammatory markers.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Shilpi Singh, Abha Meena, Suaib Luqman
Summary: Baicalin has shown significant anti-proliferative potential in various cancer cell lines, attracting interest as a potential chemotherapeutic modality. However, its clinical use is limited by low bioavailability, fast metabolism, and other factors. Improving pharmacokinetics and pharmacodynamics, as well as addressing knowledge and technology gaps, are essential for establishing baicalin as an effective and safe compound for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Nisar Ahmad, Arfan Ullah, Peng Chu, Wenzhang Tian, Zeyao Tang, Zhaolin Sun
Summary: Doxorubicin is a commonly prescribed chemotherapeutic drug worldwide, but its use is limited by harmful side effects like cardiotoxicity. This review paper focuses on the cardiomyopathy and cardiomyocyte death induced by DOX, as well as the roles of SIRT1, SIRT3, and DOX in modulating mitochondrial processes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Diqi Yang, Ruiling Yin, Qianghui Lei, Jiandi Zhu, Sha Nan, Ning Ma, Hongmei Zhu, Jianguo Chen, Li Han, Mingxing Ding, Yi Ding
Summary: Baicalin alleviates endometrial inflammatory injury by regulating autophagy and influencing the redistribution of TJ proteins, providing a new therapeutic approach for preventing embryo loss and endometritis.
Article
Cell Biology
Ying Zhang, Ping Dong, Nian Liu, Jun-Yuan Yang, Hui-Min Wang, Qing Geng
Summary: This study demonstrates that TRIM6 is highly expressed in lung cancer and acts as a negative regulator of ferroptosis. It inhibits glutaminolysis and ferroptotic cell death by promoting the degradation of solute carrier family 1 member 5. Furthermore, TRIM6 overexpression enhances the resistance of lung cancer cells to chemotherapeutic drugs.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2023)
Review
Biochemistry & Molecular Biology
Hiroki Kitakata, Jin Endo, Hidehiko Ikura, Hidenori Moriyama, Kohsuke Shirakawa, Yoshinori Katsumata, Motoaki Sano
Summary: This review discusses the molecular mechanisms of DOX-induced cardiotoxicity, focusing on apoptosis and ferroptosis as the two forms of programmed cell death. Possible therapeutic strategies to prevent DOX cardiotoxicity are also outlined, along with the significance of mitochondrial homeostasis disruption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Khalil Ur Rahman, Shuo Yang, Nasir Azam, Zhen Yuan, Jiawen Yu, Chunhui Zhao, Bin Feng
Summary: Breast cancer is a disease that affects both women and men. Early detection and treatment are crucial, and risk factors include age, family history, gene mutations, estrogen exposure, and lifestyle habits. Symptoms of breast cancer can include changes in the breast skin, lumps, changes in size or shape, and nipple discharge. Diagnosis involves various tests, and treatment options range from surgery to targeted therapy. In this study, the researchers investigated how miR-153-3p affects the sensitivity of breast cancer cells to doxorubicin, a commonly used chemotherapy drug.
Article
Biochemistry & Molecular Biology
Ivana Sirangelo, Maria Liccardo, Clara Iannuzzi
Summary: The major phenolic compound HT in olive oil shows potential in counteracting cardiotoxicity induced by Dox while not interfering with its anti-tumor properties. This study identifies HT as a promising molecule for the development of additional therapeutic approaches to prevent anthracycline-related cardiotoxicity and improve antineoplastic treatments.
Article
Environmental Sciences
Hsiu-Chung Ou, Wan-Ching Chou, Ching-Hsia Hung, Pei-Ming Chu, Pei-Ling Hsieh, Shih-Hung Chan, Kun-Ling Tsai
ENVIRONMENTAL TOXICOLOGY
(2019)
Article
Environmental Sciences
Wan-Ching Chou, Kun-Ling Tsai, Pei-Ling Hsieh, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Ching-Hou Ma
Summary: The study demonstrated the pathogenic role of Gal-3 in Gal-3-induced chondrocyte dysfunction and injuries through upregulating TLR-4 and MyD88, increasing NADPH oxidase activity, inducing ROS generation, activating NF-kappa B, and causing chondrocyte apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biology
Pei-Ming Chu, Cheng-Chia Yu, Kun-Ling Tsai, Pei-Ling Hsieh
Summary: This review discusses the roles of various non-coding RNAs (such as MALAT1, MEG3, GAS5, SNHG16, CASC2, HOTAIR) in the development of diabetic vascular complications in response to oxidative stress.
Article
Biochemistry & Molecular Biology
Pei-Ling Hsieh, Pei-Ming Chu, Hui-Ching Cheng, Yu-Ting Huang, Wan-Ching Chou, Kun-Ling Tsai, Shih-Hung Chan
Summary: This study demonstrated that dapagliflozin could mitigate doxorubicin-induced cardiotoxicity by reducing oxidative stress, improving mitochondrial dysfunction, decreasing fibrosis, hypertrophy, and inflammation through the PI3K/AKT/Nrf2 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Tsan-Hung Chiu, Chang-Wen Ku, Tsung-Jung Ho, Kun-Ling Tsai, Yi-Dung Yang, Hsiu-Chung Ou, Hsiu- Chen
Summary: Atherosclerotic lesions are a leading cause of cardiovascular diseases. Oxidized low-density lipoprotein (OxLDL) is a crucial risk factor for atherosclerosis as it contributes to endothelial dysfunction and foam cell formation. This study explores the potential protective effects of Schisanhenol, a compound extracted from the fruit of Schisandra rubriflora, against OxLDL-mediated endothelial damage. Results show that Schisanhenol reduces the expression of lectin-like OxLDL receptor-1 (LOX-1) and prevents detrimental effects induced by OxLDL, such as downregulation of endothelial nitric oxide synthase (eNOS) and activation of inducible NOS (iNOS) and inflammatory responses.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Pei-Ling Hsieh, Kun-Ling Tsai, Wan-Ching Chou, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Ching-Hou Ma
Summary: This study elucidates the detailed pathological mechanism of cisplatin on chondrocytes, demonstrating that downregulation of SIRT1 suppressed PGC-1α, inhibited Nrf2 nuclear translocation, and subsequently decreased HO-1 and NQO-1 expression, leading to oxidative stress and mitochondrial dysfunction. Additionally, the SIRT1-modulated antioxidant pathway also upregulated p38 phosphorylation, pro-inflammatory events, and matrix metalloproteinases in chondrocytes. Therefore, preserving SIRT1 in chondrocytes may be a potential target for ameliorating growth plate dysfunction in cisplatin-receiving pediatric cancer survivors.
ENVIRONMENTAL TOXICOLOGY
(2023)