Integrin β4 as a Potential Diagnostic and Therapeutic Tumor Marker

Integrin β4 Is an Effective and Efficient Marker in Synchronously Highlighting Lymphatic and Blood Vascular Invasion, and Perineural Aggression in Malignancy

(2020) Jian Li et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

ZKSCAN3 drives tumor metastasis via integrin β4/FAK/AKT mediated epithelial–mesenchymal transition in hepatocellular carcinoma

(2020) Jieqiong Li et al.   Cancer Cell International

Label-free platform on pH-responsive chitosan: Adhesive heterogeneity for cancer stem-like cell isolation from A549 cells via integrin β4

(2020) Chia-Hsiang Yen et al.   CARBOHYDRATE POLYMERS

Epigenetic regulation of the ITGB4 gene in prostate cancer

(2020) Emma J. Wilkinson et al.   EXPERIMENTAL CELL RESEARCH

Density-dependent ERK MAPK expression regulates MMP-9 and influences growth

(2019) Vincent Marchese et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Integrin beta 4 (ITGB4) and its tyrosine-1510 phosphorylation promote pancreatic tumorigenesis and regulate the MEK1-ERK1/2 signaling pathway

(2019) Xiangli Meng et al.   Bosnian Journal of Basic Medical Sciences

Real-time imaging of integrin β4 dynamics using a reporter cell line generated by Crispr/Cas9 genome editing

(2019) Ameer L. Elaimy et al.   JOURNAL OF CELL SCIENCE

ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts

(2019) Jin Sol Sung et al.   ONCOGENE

A cross-talk between integrin β4 and epidermal growth factor receptor induces gefitinib chemoresistance to gastric cancer

(2018) Jia Huafeng et al.   Cancer Cell International

Integrin-β4 is a novel transcriptional target of TAp73

(2018) Ningxia Xie et al.   CELL CYCLE

Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues

(2018) Seung Hee Jung et al.   CELL DEATH AND DIFFERENTIATION

Mucins, Mucus, and Goblet Cells

(2018) Jonathan Ma et al.   CHEST

β4-Integrin/PI3K Signaling Promotes Tumor Progression through the Galectin-3–N-Glycan Complex

(2018) Yukiko Kariya et al.   MOLECULAR CANCER RESEARCH

The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4

(2018) Sumit Siddharth et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Role of Arrestin Domain-Containing 3 in Regulating Endocytic Recycling and Extracellular Vesicle Sorting of Integrin β4 in Breast Cancer

(2018) Young Soung et al.   Cancers

Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer

(2017) L Gan et al.   ONCOGENE

Induction of Apoptosis by Berberine in Hepatocellular Carcinoma HepG2 Cells via Downregulation of NF-κB

(2017) Min Li et al.   ONCOLOGY RESEARCH

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells

(2017) Brian Bierie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic characterization and pathway analysis of berberine protects against prostate cancer

(2017) Xianna Li et al.   Oncotarget

Integrin β4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma

(2017) Xiao-Long Li et al.   Scientific Reports

Roles of Integrin α6β4 Glycosylation in Cancer

(2017) Yoshinobu Kariya et al.   Cancers

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK–AKT pathway

(2016) Chao Leng et al.   CANCER LETTERS

Elevated integrin α6β4 expression is associated with venous invasion and decreased overall survival in non–small cell lung cancer

(2016) Rachel L. Stewart et al.   HUMAN PATHOLOGY

MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling

(2016) I Lakshmanan et al.   ONCOGENE

Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERα-ΔNp63-Integrin β4 Signaling Pathway

(2016) Jar-Yi Ho et al.   PLoS One

A small molecule induces integrin β4 nuclear translocation and apoptosis selectively in cancer cells with high expression of integrin β4

(2016) ShuYan Liu et al.   Oncotarget

Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development

(2015) Jiarong Li et al.   DEVELOPMENTAL BIOLOGY

Integrin β4 and vinculin contained in exosomes are potential markers for progression of prostate cancer associated with taxane-resistance

(2015) KYOJIRO KAWAKAMI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Upregulation of integrin β4 promotes epithelial–mesenchymal transition and is a novel prognostic marker in pancreatic ductal adenocarcinoma

(2015) Y Masugi et al.   LABORATORY INVESTIGATION

Clinical significance of the integrin α6β4 in human malignancies

(2015) Rachel L Stewart et al.   LABORATORY INVESTIGATION

Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner

(2015) Keqin Tang et al.   Molecular Cancer

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

PKD2 and RSK1 Regulate Integrin β4 Phosphorylation at Threonine 1736

(2015) Lisa te Molder et al.   PLoS One

Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells

(2015) David T. Coleman et al.   PLoS One

An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer

(2015) Yu-Ling Tai et al.   Scientific Reports

Netrin-4 Promotes Glioblastoma Cell Proliferation through Integrin β4 Signaling

(2015) Yizhou Hu et al.   NEOPLASIA

Cell adhesion molecules and their relation to (cancer) cell stemness

(2014) Ensieh Farahani et al.   CARCINOGENESIS

Localization of FAK is related with colorectal carcinogenesis

(2014) Noriaki Tanaka et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Berberine induces apoptosis and DNA damage in MG-63 human osteosarcoma cells

(2014) YU ZHU et al.   Molecular Medicine Reports

Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients

(2014) Jiang Zhu et al.   PLoS One

Metallopanstimulin-1 regulates invasion and migration of gastric cancer cells partially through integrin β4

(2013) Zhong-Yin Yang et al.   CARCINOGENESIS

Activation of integrin β1-focal adhesion kinase-RasGTP pathway plays a critical role in TGF beta1-induced podocyte injury

(2013) Yu-Jing Zhang et al.   CELLULAR SIGNALLING

Epigenetic regulation of miR-21 in colorectal cancer

(2013) Angelo Ferraro et al.   Epigenetics

Id2 Complexes with the SNAG Domain of Snai1 Inhibiting Snai1-Mediated Repression of Integrin  4

(2013) C. Chang et al.   MOLECULAR AND CELLULAR BIOLOGY

Glucosamine-Induced Reduction of Integrin β4 and Plectin Complex Stimulates Migration and Proliferation in Mouse Embryonic Stem Cells

(2013) Ji Hoon Jeon et al.   STEM CELLS AND DEVELOPMENT

Critical role for integrin-β4 in the attenuation of murine acute lung injury by simvastatin

(2012) Weiguo Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Integrin β4 Regulates SPARC Protein to Promote Invasion

(2012) Kristin D. Gerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of S1PR1 and Integrin β4 in HGF/c-Met-mediated Increases in Vascular Integrity

(2012) Yulia Ephstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits

(2012) Hong Liu et al.   NATURE CELL BIOLOGY

Targeting p73 in cancer

(2011) Anna-Maria Maas et al.   CANCER LETTERS

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways

(2011) Xiao-Feng Chen et al.   MOLECULAR BIOLOGY REPORTS

PDCD4 nuclear loss inversely correlates with miR-21 levels in colon carcinogenesis

(2011) Matteo Fassan et al.   VIRCHOWS ARCHIV

ARRDC3 suppresses breast cancer progression by negatively regulating integrin β4

(2010) K M Draheim et al.   ONCOGENE

HLA Class I Molecules Partner with Integrin  4 to Stimulate Endothelial Cell Proliferation and Migration

(2010) X. Zhang et al.   Science Signaling

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

Targeting transforming growth factor (TGF)-βRI inhibits activation of β1 integrin and blocks vascular invasion in hepatocellular carcinoma

(2009) Emilia Fransvea et al.   HEPATOLOGY

Regulation of  4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition

(2009) X. Yang et al.   JOURNAL OF CELL SCIENCE

Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin β4

(2009) T Uemura et al.   ONCOGENE

Curcumin Inhibition of Integrin ( 6 4)-Dependent Breast Cancer Cell Motility and Invasion

(2008) H. I. Kim et al.   Cancer Prevention Research

Activation of Platelet-Activating Factor Receptor and Pleiotropic Effects on Tyrosine Phospho-EGFR/Src/FAK/Paxillin in Ovarian Cancer

(2008) M. Aponte et al.   CANCER RESEARCH

Analysis of Integrin  4 Expression in Human Breast Cancer: Association with Basal-like Tumors and Prognostic Significance

(2008) S. Lu et al.   CLINICAL CANCER RESEARCH

Regulation of hemidesmosome disassembly by growth factor receptors

(2008) Coert Margadant et al.   CURRENT OPINION IN CELL BIOLOGY

Polymorphisms in predicted microRNA binding sites in integrin genes and breast cancer- ITGB4 as prognostic marker

(2008) A. Brendle et al.   EJC SUPPLEMENTS

The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

(2008) Joe W. Ramos   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TAp73β and DNp73β activate the expression of the pro-survival caspase-2 S

(2008) Wen Hong Toh et al.   NUCLEIC ACIDS RESEARCH

TGF-β1 increases motility and αvβ3 integrin up-regulation via PI3K, Akt and NF-κB-dependent pathway in human chondrosarcoma cells

(2007) Ying-Yi Yeh et al.   BIOCHEMICAL PHARMACOLOGY

Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells

(2007) Wei-Jiunn Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY