The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex

Mechanisms of γ-Secretase Activation and Substrate Processing

(2020) Apurba Bhattarai et al.   ACS Central Science

Structural Modeling of γ-Secretase Aβn Complex Formation and Substrate Processing

(2019) Manuel Hitzenberger et al.   ACS Chemical Neuroscience

Recognition of the amyloid precursor protein by human γ-secretase

(2019) Rui Zhou et al.   SCIENCE

γ-Secretase Studied by Atomistic Molecular Dynamics Simulations: Global Dynamics, Enzyme Activation, Water Distribution and Lipid Binding

(2019) Manuel Hitzenberger et al.   Frontiers in Chemistry

APH-1A Component of γ-Secretase Forms an Internal Water and Ion-Containing Cavity

(2019) Rodrigo Aguayo-Ortiz et al.   ACS Chemical Neuroscience

Structure of APP-C99 1–99 and implications for role of extra-membrane domains in function and oligomerization

(2018) George A. Pantelopulos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Drug development for Alzheimer’s disease: review

(2018) Kejing Lao et al.   JOURNAL OF DRUG TARGETING

Dissecting conformational changes in APP’s transmembrane domain linked to ε-efficiency in familial Alzheimer’s disease

(2018) Alexander Götz et al.   PLoS One

Structural basis of Notch recognition by human γ-secretase

(2018) Guanghui Yang et al.   NATURE

How γ-secretase hits a moving target

(2016) Charles R Sanders   eLife

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

(2016) David M Bolduc et al.   eLife

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

New ways to boost molecular dynamics simulations

(2015) Elmar Krieger et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics

(2015) D. Langosch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

The dynamic conformational landscape of  -secretase

(2014) N. Elad et al.   JOURNAL OF CELL SCIENCE

The Role of Cholesterol Metabolism in Alzheimer’s Disease

(2014) Jia-Hao Sun et al.   MOLECULAR NEUROBIOLOGY

Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques

(2014) Anna Pensalfini et al.   NEUROBIOLOGY OF DISEASE

γ-Secretase Associated with Lipid Rafts

(2013) Nobutaka Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new roadmap for drug development for Alzheimer's disease

(2013) Robert E. Becker et al.   NATURE REVIEWS DRUG DISCOVERY

Bendix: intuitive helix geometry analysis and abstraction

(2012) A. C. E. Dahl et al.   BIOINFORMATICS

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

Membrane rafts in Alzheimer's disease beta-amyloid production

(2010) Kulandaivelu S. Vetrivel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Structures of β-Amyloid Peptide 1−40, 1−42, and 1−55—the 672−726 Fragment of APP—in a Membrane Environment with Implications for Interactions with γ-Secretase

(2009) Naoyuki Miyashita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Active γ-secretase is localized to detergent-resistant membranes in human brain

(2008) Ji-Yeun Hur et al.   FEBS Journal

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY