Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa

Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration

(2020) Katherine J. Wert et al.   EBioMedicine

Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies

(2020) Shun-Yun Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium

(2020) Celia M. Bisbach et al.   Cell Reports

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

(2020) Mari B. Ishak Gabra et al.   Nature Communications

Thioredoxin Delays Photoreceptor Degeneration, Oxidative and Inflammation Alterations in Retinitis Pigmentosa

(2020) Roberto Gimeno-Hernández et al.   Frontiers in Pharmacology

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Proline mediates metabolic communication between retinal pigment epithelial cells and the retina

(2019) Michelle Yam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

(2017) Mark A Kanow et al.   eLife

Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis

(2017) William L. Holland et al.   Molecular Metabolism

Short-term succinic acid treatment mitigates cerebellar mitochondrial OXPHOS dysfunction, neurodegeneration and ataxia in a Purkinje-specific spinocerebellar ataxia type 1 (SCA1) mouse model

(2017) Austin Ferro et al.   PLoS One

Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosa

(2016) Lijuan Zhang et al.   HUMAN MOLECULAR GENETICS

Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration

(2016) Lijuan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Role of metabolism in neurodegenerative disorders

(2016) Claudio Procaccini et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium

(2016) Jianhai Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An isotope-labeled chemical derivatization method for the quantitation of short-chain fatty acids in human feces by liquid chromatography–tandem mass spectrometry

(2015) Jun Han et al.   ANALYTICA CHIMICA ACTA

Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis

(2015) Najate Aït-Ali et al.   CELL

Neuronal cell cycle: the neuron itself and its circumstances

(2015) José M Frade et al.   CELL CYCLE

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Genes and Mutations Causing Autosomal Dominant Retinitis Pigmentosa

(2014) Stephen P. Daiger et al.   Cold Spring Harbor Perspectives in Medicine

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

(2013) Sarah-Maria Fendt et al.   Nature Communications

Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice

(2011) Akiko Kubo et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Probing Mechanisms of Photoreceptor Degeneration in a New Mouse Model of the Common Form of Autosomal Dominant Retinitis Pigmentosa due to P23H Opsin Mutations

(2011) Sanae Sakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

Active HIF-1 in the Normal Human Retina

(2009) John M. Hughes et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

ATP Consumption by Mammalian Rod Photoreceptors in Darkness and in Light

(2008) Haruhisa Okawa et al.   CURRENT BIOLOGY

Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

(2008) Claudio Punzo et al.   NATURE NEUROSCIENCE