Optogenetic modulation of cardiac action potential properties may prevent arrhythmogenesis in short and long QT syndromes

Cardiac optogenetics: a decade of enlightenment

(2020) Emilia Entcheva et al.   Nature Reviews Cardiology

Modeling Reentry in the Short QT Syndrome With Human-Induced Pluripotent Stem Cell–Derived Cardiac Cell Sheets

(2019) Rami Shinnawi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia

(2019) Maximilian Funken et al.   Frontiers in Physiology

Human Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets Expressing Genetically Encoded Voltage Indicator for Pharmacological and Arrhythmia Studies

(2018) Naim Shaheen et al.   Stem Cell Reports

Light-Activated Dynamic Clamp Using iPSC-Derived Cardiomyocytes

(2018) Bonnie Quach et al.   BIOPHYSICAL JOURNAL

Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations

(2016) Tobias Bruegmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Anion channelrhodopsins for inhibitory cardiac optogenetics

(2016) Elena G. Govorunova et al.   Scientific Reports

Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation

(2016) Claudia Crocini et al.   Scientific Reports

Systemic gene transfer enables optogenetic pacing of mouse hearts

(2015) C. C. Vogt et al.   CARDIOVASCULAR RESEARCH

Optogenetics for in vivo cardiac pacing and resynchronization therapies

(2015) Udi Nussinovitch et al.   NATURE BIOTECHNOLOGY

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics

(2015) E. G. Govorunova et al.   SCIENCE

Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters

(2015) Rami Shinnawi et al.   Stem Cell Reports

Optogenetics for suppression of cardiac electrical activity in human and rat cardiomyocyte cultures

(2015) Udi Nussinovitch et al.   Neurophotonics

Modulation of cardiac tissue electrophysiological properties with light-sensitive proteins

(2014) Udi Nussinovitch et al.   CARDIOVASCULAR RESEARCH

Optogenetics-enabled dynamic modulation of action potential duration in atrial tissue: feasibility of a novel therapeutic approach

(2014) T. V. Karathanos et al.   EUROPACE

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Chemically defined generation of human cardiomyocytes

(2014) Paul W Burridge et al.   NATURE METHODS

Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients

(2012) Limor Zwi-Dantsis et al.   EUROPEAN HEART JOURNAL

The Microbial Opsin Family of Optogenetic Tools

(2011) Feng Zhang et al.   CELL

Stimulating Cardiac Muscle by Light

(2011) Zhiheng Jia et al.   Circulation-Arrhythmia and Electrophysiology

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Short QT Syndrome: From Bench to Bedside

(2010) Chinmay Patel et al.   Circulation-Arrhythmia and Electrophysiology

Optogenetic control of heart muscle in vitro and in vivo

(2010) Tobias Bruegmann et al.   NATURE METHODS

Optogenetic Control of Cardiac Function

(2010) A. B. Arrenberg et al.   SCIENCE

Cell Therapy for Modification of the Myocardial Electrophysiological Substrate

(2008) Lior Yankelson et al.   CIRCULATION

Long QT Syndrome

(2008) Ilan Goldenberg et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY