Article
Food Science & Technology
Ali Muhammed Moula Ali, Anderson S. Sant'Ana, Sri Charan Bindu Bavisetty
Summary: This article reviews the development and application of cheese preservation strategies, including advanced technologies and natural antimicrobial agents. Advanced technologies have broad-spectrum antimicrobial action with minimal adverse effects on cheese quality, while the direct addition of plant extracts negatively affects cheese properties, but can be minimized by encapsulation and film forms.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Computer Science, Theory & Methods
Shibli Nisar, Muhammad Ali Zuhaib, Abasin Ulasyar, Muhammad Tariq
Summary: This paper proposes a novel model based on hybrid advanced technologies to track and monitor COVID-19 patients with high accuracy, while preserving privacy and being cost-effective.
Review
Green & Sustainable Science & Technology
Xingyao Meng, Qingping Wang, Xixi Zhao, Yafan Cai, Xuguang Ma, Jingyi Fu, Pan Wang, Yongjing Wang, Wei Liu, Lianhai Ren
Summary: Anaerobic digestion is a biotechnology that aligns with greenhouse gas reduction policies and circular economy development goals. The quality and activity of inoculum are crucial in ensuring the successful start-up and stable operation of anaerobic digestion reactors. However, there is a lack of cost-effective, ready-to-use methanogenic culture for anaerobic digestion systems. Various preservation strategies for inoculum, including wet storage, dehydrated storage, and freeze-drying, have been evaluated. Freeze-drying with an effective cryoprotectant may yield the best results for preserving anaerobic inoculum.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Ziya Isiksacan, Angelo D'Alessandro, Susan M. Wolf, David H. McKenna, Shannon N. Tessier, Erdem Kucukal, A. Aslihan Gokaltun, Nishaka William, Rebecca D. Sandlin, John Bischof, Narla Mohandas, Michael P. Busch, Caglar Elbuken, Umut A. Gurkan, Mehmet Toner, Jason P. Acker, Martin L. Yarmush, O. Berk Usta
Summary: Transfusion of red blood cells is a valuable and widespread treatment in modern medicine. Current practices in blood transfusion overlook the variability in stored red blood cell quality. It is necessary to rethink transfusion medicine workflows and utilize novel technologies for assessing red blood cell quality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Orthopedics
Roy Aaron, David Aaron, Jennifer Racine-Avila, Jerry Menikoff
Summary: This discussion addresses the ethical, legal, and financial issues surrounding research with human biospecimens, highlighting the potential constraints the donor control may place on researchers' freedom. Concepts underlying consent to donate biospecimens and the impact of the common rule revision on research are discussed. Transactional aspects of biospecimen donation and the implications of donor control of secondary research use are also examined.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Review
Food Science & Technology
Wanli Zhang, Yonggui Pan, Yueming Jiang, Zhengke Zhang
Summary: This study summarizes the application of gas fumigation technology in postharvest fruit quality management and the related biochemical mechanisms. Gas fumigants, such as SO2, ClO2, ozone, NO, CO, 1-MCP, essential oils, H2S, and ethanol, have been found to effectively improve postharvest fruit quality by delaying senescence, inhibiting browning, controlling disease, and alleviating chilling injury. Gas preservatives play multiple roles in postharvest fruit quality control, including antifungal agent, anti-browning agent, redox agent, ethylene inhibitors, elicitor, and pesticide remover. Recent developments in slow-release gas fumigation treatments suggest potential for improved performance. However, some gas fumigants may have side effects on the fruit, which needs to be addressed with combined treatments.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Multidisciplinary
Jia-Sheng Lin, Xiang-Dong Tian, Gang Li, Fan-Li Zhang, Yan Wang, Jian-Feng Li
Summary: The use of imaging technologies is crucial in understanding biological phenomena. Traditional imaging modalities lack the necessary spatial resolution for high-precision research and diagnosis in the biomedical field. Plasmon resonance, an interaction between light and matter, allows for intense electromagnetic fields and enhances various processes such as ablation, scattering, and photoluminescence. By combining spatially resolved capability with molecular spectrometry techniques, excellent imaging techniques have been developed for studying biological processes. This review provides an overview of plasmonics and discusses the working principles and achievable spatial resolutions of various plasmon-based imaging techniques.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Chemistry, Analytical
Shaohua Zhang, Jinqi Deng, Jianbin Li, Fei Tian, Chao Liu, Luo Fang, Jiashu Sun
Summary: Extracellular vesicles (EVs) have attracted significant attention as potential non-invasive cancer diagnostic biomarkers. However, isolating and analyzing EVs from biofluids remains challenging. Microfluidic techniques offer promising advantages for efficient and precise isolation and analysis of EVs.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Medical Laboratory Technology
Marina Mordenti, Valentina Capicchioni, Serena Corsini, Manuela Locatelli, Elisabetta Abelli, Federico Banchelli, Manila Boarini, Luca Sangiorgi
Summary: Based on the overall evaluation criteria, the results indicate that DNA extracted from all samples, shortly preserved, have suitable quality and reliable reproducibility to be used in diagnostic activities and biomedical research, even if DNA from peripheral blood mononuclear cells is more affected by the experimental conditions.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Chemistry, Multidisciplinary
Chiara Crivello, Semih Sevim, Octavio Graniel, Carlos Franco, Salvador Pane, Josep Puigmarti-Luis, David Munoz-Rojas
Summary: Metal-organic framework (MOF) thin films, with tunable porosity, large internal surface area, and high crystallinity, have shown potential applications in gas sensing, microelectronics, photovoltaics, and membrane-based separation technologies. Despite recent attention, challenges remain in manufacturing and integration, requiring the development of more effective methods.
MATERIALS HORIZONS
(2021)
Review
Agriculture, Multidisciplinary
Jingyi Huo, Min Zhang, Dayuan Wang, Arun S. Mujumdar, Bhesh Bhandari, Lujun Zhang
Summary: Edible mushrooms are popular due to their nutritional value, taste, and medicinal properties. However, they require appropriate post-harvest processing and preservation to prevent texture changes, microbial infestation, and nutrient loss. Factors such as quality, source, contamination, damage, and residues should be carefully tested to ensure safety. New technologies, such as electrofluidic drying and cold plasma treatment, as well as advanced detection methods like NMR and imaging technology, have been developed for mushroom preservation and quality detection.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Chemistry, Multidisciplinary
Rares-Lucian Chiriac, Anghel Chiru, Razvan Gabriel Boboc, Ulf Kurella
Summary: Research on internal combustion engines has shown that turbocharging can increase efficiency and drive electricity generators. Experimental results demonstrate that turbos have high potential and can be used with generators without decreasing efficiency.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Thuy Truong An Nguyen, Isabelle Demeestere
Summary: The current methods for fertility preservation are not suitable for all cancer patients, and an emerging strategy called pharmacoprotection shows potential in filling this gap. Gold nanoparticles have unique properties that make them an attractive candidate for drug delivery systems. MicroRNA therapy is also considered a next-generation approach, but its clinical availability is hindered by obstacles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Automation & Control Systems
Wei Wei, Syed Hassan Ahmed
Summary: AIoT is a new intelligence structure that integrates AI and IoT for devices to understand data, observe the environment, and make decisions. Challenges arise from the connections between cloud, edge, blockchain, 5G, and AI, requiring collaborative approaches and rethinking of architecture, communication, and processing.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2022)
Article
Food Science & Technology
Shiyi Peng, Huamao Wei, Shengnan Zhan, Wenge Yang, Qiaoming Lou, Shanggui Deng, Xunxin Yu, Tao Huang
Summary: This review comprehensively summarizes the spoilage mechanism and quality changes of shrimp during storage. It discusses various preservation technologies and their advantages and disadvantages, as well as the limited applications of novel preservation technologies. The findings suggest that novel preservation technologies can effectively prolong the shelf-life of shrimp with high quality, but further studies are needed for commercialization.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Aylin Acun, Ruben Oganesyan, Korkut Uygun, Heidi Yeh, Martin L. Yarmush, Basak E. Uygun
Summary: The extracellular matrix of the liver changes with age, affecting cell function, and donor age should be considered an important factor for bioengineering liver substitutes.
Article
Multidisciplinary Sciences
Hai Wang, Yutong Liang, Yue Yin, Jie Zhang, Wen Su, Alisa M. White, Bin Jiang, Jiangsheng Xu, Yuntian Zhang, Samantha Stewart, Xiongbin Lu, Xiaoming He
Summary: The FSCNO hybrid nanoparticle targets tumor vasculature to release P-gp inhibitor and anticancer drug, improving drug bioavailability inside cells. The nano-onion shows superior light absorption in the NIR region, enabling triggered drug release at low power.
NATURE COMMUNICATIONS
(2021)
Article
Anatomy & Morphology
Jenna Dumbleton, James G. Shamul, Bin Jiang, Pranay Agarwal, Haishui Huang, Xiaofeng Jia, Xiaoming He
Summary: This study investigates directed neural differentiation of murine ESCs using a non-planar microfluidic device to encapsulate cells in 3D microcapsules with alginate hydrogel shells. Modifications of the hydrogel shell facilitate early neurite extension and demonstrate potential for further neural differentiation into specialized neurons for therapeutic applications.
CELLS TISSUES ORGANS
(2022)
Article
Engineering, Biomedical
Bin Jiang, Wenquan Ou, James G. Shamul, Hao Chen, Sarah Van Belleghem, Samantha Stewart, Zhenguo Liu, John P. Fisher, Xiaoming He
Summary: The use of Rock inhibitor (RI) in 3D cardiac differentiation of human induced pluripotent stem cells (iPSCs) poses challenges, but reducing the RI concentration can improve efficiency and homogeneity, which is important for understanding and treating heart diseases.
BIOACTIVE MATERIALS
(2022)
Article
Thermodynamics
Elyahb Allie Kwizera, Samantha Stewart, Md Musavvir Mahmud, Xiaoming He
Summary: Magnetic nanoparticles, especially superparamagnetic iron oxide nanoparticles, have garnered significant attention for their easy synthesis, functionalization, and control over size and shape. They have shown potential in various biomedical applications, including thermal treatments for cancer and enhancement of cryopreservation. Challenges in the use of magnetic nanoparticles in these biomedical applications are also discussed.
JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME
(2022)
Article
Chemistry, Multidisciplinary
Jiangsheng Xu, Yunhua Liu, Sheng Liu, Wenquan Ou, Alisa White, Samantha Stewart, Katherine H. R. Tkaczuk, Lee M. Ellis, Jun Wan, Xiongbin Lu, Xiaoming He
Summary: Colon and rectal cancers are leading causes of cancer-related deaths in the United States. Genomic analyses reveal the frequent hemizygous deletion of TP53 gene, an important tumor suppressor, in both cancers. Targeting TP53 directly has been unsuccessful, but the co-deletion of POLR2A gene with TP53 in these cancers suggests RNA interference with POLR2A siRNA as a potential strategy. However, efficient delivery of siRNA into the cytosol is a major challenge. To overcome this barrier, pH-responsive MetC-nanoparticles with a bomb effect are developed for effective cytosolic delivery of POLR2A siRNA, enhancing therapeutic efficacy for TP53-deficient cancer.
Article
Engineering, Biomedical
Beyza Bulutoglu, Aylin Acun, Sarah L. Deng, Safak Mert, Elise Lupon, Alexandre G. Lellouch, Curtis L. Cetrulo, Basak E. Uygun, Martin L. Yarmush
Summary: Elastin-like peptides (ELPs) are a versatile platform for tissue engineering and drug delivery. In this study, therapeutic molecules are genetically fused to ELPs and applied to wound healing. The results show that the fused molecules retain their bioactivity and the application of these ELP nanoparticles significantly promotes wound closure in diabetic mice.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jiangsheng Xu, James G. Shamul, Elyahb Allie Kwizera, Xiaoming He
Summary: Mitochondria are critical organelles for producing energy in cells and can be targeted for cancer therapy. Mitochondria-targeting nanotechnologies have shown high efficacy for cancer treatment both in vitro and in vivo, and can be intelligently designed based on the characteristics of the tumor microenvironment.
Article
Chemistry, Multidisciplinary
Elyahb A. Kwizera, Wenquan Ou, Sojeong Lee, Samantha Stewart, James G. Shamul, Jiangsheng Xu, Nancy Tait, Katherine H. R. Tkaczuk, Xiaoming He
Summary: In this study, a robust electromicrofluidic chip was developed for efficient capture and release of heterogeneous circulating tumor cells (CTCs), which is important for cancer research and therapeutic development.
Correction
Chemistry, Multidisciplinary
Elyahb A. Kwizera, Wenquan Ou, Sojeong Lee, Samantha Stewart, James G. Shamul, Jiangsheng Xu, Nancy Tait, Katherine H. R. Tkaczuk, Xiaoming He
Article
Engineering, Biomedical
Bin Jiang, Alisa White, Wenquan Ou, Sarah Van Belleghem, Samantha Stewart, James G. Shamul, Shaik O. Rahaman, John P. Fisher, Xiaoming He
Summary: The conventional approach for fabricating PDMS microfluidic devices is inconvenient and requires specialized facilities. This study discovered that reducing the curing agent for crosslinking the PDMS prepolymer increases the noncovalent binding energy of the PDMS surfaces, allowing for the convenient fabrication of leak-free microfluidic devices without the need for plasma or other treatments. This method enables easy loading and retrieval of cells and is faster and more convenient than the conventional covalent bonding method.
BIOACTIVE MATERIALS
(2022)
Article
Genetics & Heredity
Pei-Chih Lee, Samantha Stewart, Olga Amelkina, Hannah Sylvester, Xiaoming He, Pierre Comizzoli
Summary: Intracellular trehalose delivery through CRNPs improves the dehydration tolerance of COCs, opening up new possibilities for oocyte storage and preservation of fertility at ambient temperatures.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Retraction
Chemistry, Multidisciplinary
Hai Wang, Pranay Agarwal, Gang Zhao, Guang Ji, Christopher M. Jewell, John P. Fisher, Xiongbin Lu, Xiaoming He
ACS CENTRAL SCIENCE
(2023)
Article
Engineering, Biomedical
Samantha Stewart, Wenquan Ou, Helim Aranda-Espinoza, Shaik O. Rahaman, Xiaoming He
Summary: Ovarian follicles develop in a regulated mechanical microenvironment, and disruptions to this microenvironment can cause infertility. The viscoelastic properties of ovarian tissue have not been extensively studied. This study characterizes the elastic and viscoelastic properties of ovarian tissue from both reproductive age groups of domestic cats and identifies possible connections between mechanical and compositional heterogeneities. These findings may have important implications for biomimetic follicle culture.
ACTA BIOMATERIALIA
(2023)
Review
Reproductive Biology
Pierre Comizzoli, Xiaoming He, Pei-Chih Lee
Summary: Preserving germ cells and gonadal tissues for the long term is critical in fertility treatment and animal population management. Current options at freezing temperatures are often constraining, but recent research suggests alternative strategies based on dehydration and storage at supra-zero temperatures. Further studies are needed for rehydration and reanimation of germ cells.
REPRODUCTION AND FERTILITY
(2022)
