Cell Line Platforms Support Research into Arthropod Immunity

The Interplay Between Viruses and RNAi Pathways in Insects

(2021) Bryony C. Bonning et al.   Annual Review of Entomology

Imd pathway-specific immune assays reveal NF-κB stimulation by viral RNA PAMPs in Aedes aegypti Aag2 cells

(2021) Tiffany A. Russell et al.   PLoS Neglected Tropical Diseases

Eicosanoid Signaling in Insect Immunology: New Genes and Unresolved Issues

(2021) Yonggyun Kim et al.   Genes

Step aside CRISPR, RNA editing is taking off

(2020) Sara Reardon   NATURE

Heat shock proteins (HSP 90, 70, 60, and 27) in Galleria mellonella (Lepidoptera) hemolymph are affected by infection with Conidiobolus coronatus (Entomophthorales)

(2020) Anna Katarzyna Wrońska et al.   PLoS One

Taking Insect Immunity to the Single-Cell Level

(2020) Sarah Hélène Merkling et al.   TRENDS IN IMMUNOLOGY

Cell Lines for Honey Bee Virus Research

(2020) Ya Guo et al.   Viruses-Basel

Immune priming: the secret weapon of the insect world

(2020) Gerard Sheehan et al.   Virulence

Iron in infection and immunity

(2020) Manfred Nairz et al.   MOLECULAR ASPECTS OF MEDICINE

Prostaglandins influence protein phosphorylation in established insect cell line

(2020) David Stanley et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Increased expression of Suppressor of cytokine signaling 2 (BmSOCS2) is correlated with suppression of Bombyx mori nucleopolyhedrovirus replication in silkworm larval tissues and cells

(2020) Yi Yuan et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

The Ras/ERK signaling pathway couples antimicrobial peptides to mediate resistance to dengue virus in Aedes mosquitoes

(2020) Wen-Quan Liu et al.   PLoS Neglected Tropical Diseases

A Toll-Spätzle Pathway in the Immune Response of Bombyx mori

(2020) Bin Yu et al.   Insects

In Vitro Insect Muscle for Tissue Engineering Applications

(2019) Natalie R. Rubio et al.   ACS Biomaterials-Science & Engineering

Prostaglandins and Other Eicosanoids in Insects: Biosynthesis and Biological Actions

(2019) David Stanley et al.   Frontiers in Physiology

Integrative single-cell analysis

(2019) Tim Stuart et al.   NATURE REVIEWS GENETICS

Thawing, Culturing, and Cryopreserving Drosophila Cell Lines

(2019) Arthur Luhur et al.   Jove-Journal of Visualized Experiments

The diversity of pattern recognition receptors (PRRs) involved with insect defense against pathogens

(2019) Xialu Wang et al.   Current Opinion in Insect Science

Small RNA responses of Culex mosquitoes and cell lines during acute and persistent virus infection

(2019) Claudia Rückert et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Expanding the canon: Non-classical mosquito genes at the interface of arboviral infection

(2019) Leah T. Sigle et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Immune and xenobiotic responses of glutathione S-Transferase theta (GST-θ) from marine invertebrate disk abalone (Haliotis discus discus): With molecular characterization and functional analysis

(2019) W.M. Gayashani Sandamalika et al.   FISH & SHELLFISH IMMUNOLOGY

Technology Feature | Beyond CRISPR: What’s current and upcoming in genome editing

(2019) Chris Tachibana   SCIENCE

Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors

(2019) Laura R.H. Ahlers et al.   Cell Reports

Pattern recognition receptors in Drosophila immune responses

(2019) Yuzhen Lu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Emerging Mechanisms of Insulin-Mediated Antiviral Immunity in Drosophila melanogaster

(2019) Chasity E. Trammell et al.   Frontiers in Immunology

Morphological and functional characterization of honey bee, Apis mellifera, hemocyte cell communities

(2018) Rodney T. Richardson et al.   APIDOLOGIE

The Coming Age of Insect Cells for Manufacturing and Development of Protein Therapeutics

(2018) Christine M. Yee et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Insights into RNAi-based antiviral immunity in Lepidoptera: acute and persistent infections in Bombyx mori and Trichoplusia ni cell lines

(2018) Dulce Santos et al.   Scientific Reports

Small interfering RNA pathway contributes to antiviral immunity in Spodoptera frugiperda (Sf9) cells following Autographa californica multiple nucleopolyhedrovirus infection

(2018) Naeime Karamipour et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

RNAi-mediated antiviral immunity in insects and their possible application

(2018) Mayke Leggewie et al.   Current Opinion in Virology

Insect Antimicrobial Peptides, a Mini Review

(2018) Qinghua Wu et al.   Toxins

Peptidoglycan recognition proteins in insect immunity

(2018) Qiang Wang et al.   MOLECULAR IMMUNOLOGY

Prostaglandin actions in established insect cell lines

(2017) Yao-Fa Li et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

A Review of Insect Cell Culture: Establishment, Maintenance and Applications in Entomological Research

(2017) S. Arunkarthick et al.   JOURNAL OF ENTOMOLOGICAL SCIENCE

Participation of 14-3-3ε and 14-3-3ζ proteins in the phagocytosis, component of cellular immune response, in Aedes mosquito cell lines

(2017) Abel Trujillo-Ocampo et al.   Parasites & Vectors

Infection-derived lipids elicit an immune deficiency circuit in arthropods

(2017) Dana K. Shaw et al.   Nature Communications

Characterization of the Zika virus induced small RNA response in Aedes aegypti cells

(2017) Margus Varjak et al.   PLoS Neglected Tropical Diseases

Regulation of Antimicrobial Peptides in Aedes aegypti Aag2 Cells

(2017) Rudian Zhang et al.   Frontiers in Cellular and Infection Microbiology

Memory and Specificity in the Insect Immune System: Current Perspectives and Future Challenges

(2017) Dustin Cooper et al.   Frontiers in Immunology

Fluorescent membrane markers elucidate the association of Borrelia burgdorferi with tick cell lines

(2016) R.C. Teixeira et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Antimicrobial activity of mosquito cecropin peptides against Francisella

(2016) Akanksha Kaushal et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Insect immunology and hematopoiesis

(2016) Julián F. Hillyer   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Fat body and hemocyte contribution to the antimicrobial peptide synthesis in Calliphora vicina R.-D. (Diptera: Calliphoridae) larvae

(2016) Andrey Yu Yakovlev et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Persistent RNA virus infection of lepidopteran cell lines: Interactions with the RNAi machinery

(2016) Luc Swevers et al.   JOURNAL OF INSECT PHYSIOLOGY

The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania

(2016) Bruno Tinoco-Nunes et al.   Parasites & Vectors

Extracellular HSPs: The Complicated Roles of Extracellular HSPs in Immunity

(2016) Stuart K. Calderwood et al.   Frontiers in Immunology

Development of primary cell cultures using hemocytes and phagocytic tissue cells of Locusta migratoria: an application for locust immunity studies

(2015) Tewodros Firdissa Duressa et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

The Baculovirus Antiapoptotic p35 Protein Functions as an Inhibitor of the Host RNA Interference Antiviral Response

(2015) Mohammad Mehrabadi et al.   JOURNAL OF VIROLOGY

Ixodes scapularis and Ixodes ricinus tick cell lines respond to infection with tick-borne encephalitis virus: transcriptomic and proteomic analysis

(2015) Sabine Weisheit et al.   Parasites & Vectors

Circulating Hemocytes from Larvae of the Japanese Rhinoceros Beetle Allomyrina dichotoma (Linnaeus) (Coleoptera: Scarabaeidae) and the Cellular Immune Response to Microorganisms

(2015) Sejung Hwang et al.   PLoS One

Bacterial and fungal pattern recognition receptors in homologous innate signaling pathways of insects and mammals

(2015) Bethany A. Stokes et al.   Frontiers in Microbiology

Clip-domain serine proteases as immune factors in insect hemolymph

(2015) Michael R Kanost et al.   Current Opinion in Insect Science

RNA interference-mediated antiviral defense in insects

(2015) Don B Gammon et al.   Current Opinion in Insect Science

Eicosanoid Signaling in Insects: from Discovery to Plant Protection

(2014) David Stanley et al.   CRITICAL REVIEWS IN PLANT SCIENCES

Identification and partial characterisation of new members of the Ixodes ricinus defensin family

(2014) Miray Tonk et al.   GENE

Modulation of the transcriptional response of innate immune and RNAi genes upon exposure to dsRNA and LPS in silkmoth-derived Bm5 cells overexpressing BmToll9-1 receptor

(2014) Jisheng Liu et al.   JOURNAL OF INSECT PHYSIOLOGY

Mosquito cell lines: history, isolation, availability and application to assess the threat of arboviral transmission in the United Kingdom

(2014) Thomas Walker et al.   Parasites & Vectors

Roles of Peroxinectin in PGE2-Mediated Cellular Immunity in Spodoptera exigua

(2014) Jiyeong Park et al.   PLoS One

Mosquito hemocyte-mediated immune responses

(2014) Julián F Hillyer et al.   Current Opinion in Insect Science

Baculovirus replication induces the expression of heat shock proteins in vivo and in vitro

(2013) Jonathan E. Breitenbach et al.   ARCHIVES OF VIROLOGY

MicroRNAome of Spodoptera frugiperda cells (Sf9) and its alteration following baculovirus infection

(2013) M. Mehrabadi et al.   JOURNAL OF GENERAL VIROLOGY

ERK signaling couples nutrient status to antiviral defense in the insect gut

(2013) J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of bacterial challenge on ferritin regulation in the yellow fever mosquito,Aedes aegypti

(2012) Dawn L. Geiser et al.   Insect Science

Prostaglandin A2 influences gene expression in an established insect cell line (BCIRL-HzAM1) cells

(2012) David W. Stanley et al.   JOURNAL OF INSECT PHYSIOLOGY

Validation of Aedes aegypti Aag-2 cells as a model for insect immune studies

(2012) Ana Barletta et al.   Parasites & Vectors

Arbovirus-Derived piRNAs Exhibit a Ping-Pong Signature in Mosquito Cells

(2012) Nicolas Vodovar et al.   PLoS One

Phenoloxidase Activity Acts as a Mosquito Innate Immune Response against Infection with Semliki Forest Virus

(2012) Julio Rodriguez-Andres et al.   PLoS Pathogens

Production of Virus-Derived Ping-Pong-Dependent piRNA-like Small RNAs in the Mosquito Soma

(2012) Elaine M. Morazzani et al.   PLoS Pathogens

Manduca sexta moricin promoter elements can increase promoter activities of Drosophila melanogaster antimicrobial peptide genes

(2011) Xiang-Jun Rao et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Drosophila cellular immunity: a story of migration and adhesion

(2011) M.-O. Fauvarque et al.   JOURNAL OF CELL SCIENCE

Cell lines, Md108 and Md66, from the hemocytes of Malacosoma disstria (Lepidoptera) display aspects of plasma-free innate non-self activities

(2011) Jason F. Lapointe et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

Alterations in the Aedes aegypti Transcriptome during Infection with West Nile, Dengue and Yellow Fever Viruses

(2011) Tonya M. Colpitts et al.   PLoS Pathogens

The UGA-CiE1 cell line from Chrysodeixis includens exhibits characteristics of granulocytes and is permissive to infection by two viruses

(2010) Jena A. Johnson et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

The insect cellular immune response

(2010) Michael R. Strand   Insect Science

Insect cell culture and applications to research and pest management

(2009) Guy Smagghe et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense

(2009) J. A. Souza-Neto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation

(2008) T. L. Tootle et al.   DEVELOPMENT

Cellular and molecular characterization of an embryonic cell line (BME26) from the tick Rhipicephalus (Boophilus) microplus

(2008) Eliane Esteves et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Intracellular infection of tick cell lines by the entomopathogenic fungus Metarhizium anisopliae

(2008) T. J. Kurtti et al.   MICROBIOLOGY-SGM

Non-specific antiviral response detected in RNA-treated cultured cells of the sandfly, Lutzomyia longipalpis

(2007) A.N. Pitaluga et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Prostaglandins A1 and E1 influence gene expression in an established insect cell line (BCIRL-HzAM1 cells)

(2007) D STANLEY et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Eicosanoids mediate insect hemocyte migration

(2007) Deepali Merchant et al.   JOURNAL OF INSECT PHYSIOLOGY