Article
Parasitology
Ningxin Zhou, Enjiong Huang, Xiaoxia Guo, Yiping Xiong, Jingwen Xie, Tong Cai, Yutong Du, Qixing Wu, Sihan Guo, Wanrong Han, Hengduan Zhang, Dan Xing, Tongyan Zhao, Yuting Jiang
Summary: This study investigated the ability of CFAV, a mosquito-specific virus, to colonize and influence vector competence in Ae. aegypti mosquitoes. The study found that CFAV derived from Aag2 cells efficiently replicated in mosquitoes without impacting their survival. However, the virus could not be vertically transmitted to the offspring, providing valuable insights into the colonization of mosquitoes by CFAV.
PARASITES & VECTORS
(2023)
Article
Biochemistry & Molecular Biology
Nasir Mehmood, Ali Hassan, Xueshan Zhong, Yongzhang Zhu, Guang Ouyang, Qiuying Huang
Summary: Entomopathogenic fungi are promising biocontrol agents for mosquitoes and understanding their effects on mosquito behavior and physiology can guide the development of novel control strategies. This study found that silencing certain genes involved in the immune response of mosquitoes resulted in decreased fitness, including reduced survival, self-grooming, flight activity, antifungal activity, and antimicrobial peptide production. These findings highlight the importance of studying the behavioral and physiological defenses of mosquitoes against fungi.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Meng-Meng Chang, Yan-Hong Wang, Qing-Tai Yang, Xue-Li Wang, Mao Wang, Alexander S. Raikhel, Zhen Zou
Summary: The study reveals the negative impact of juvenile hormone on the expression of immunity-related genes in female mosquitoes. It further demonstrates the important role of juvenile hormone in regulating mosquito immune responses. The findings suggest that juvenile hormone suppresses antimicrobial peptide gene expression through its receptor Met, while PGRP-LC activates this gene, indicating dual regulation by both the juvenile hormone and IMD signaling pathways.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Sarah E. Maguire, Ali Afify, Loyal A. Goff, Christopher J. Potter
Summary: In mosquitoes, ectopic expression of AgOR inhibits the activity of expressing neurons and leads to significant downregulation of most AgOR transcripts. Additionally, the gene choice of AgOR remains active into adulthood and the expression of AgOR2 inhibits the turning on of AgORs at this late stage.
Article
Multidisciplinary Sciences
Shinji Kasai, Kentaro Itokawa, Nozomi Uemura, Aki Takaoka, Shogo Furutani, Yoshihide Maekawa, Daisuke Kobayashi, Nozomi Imanishi-Kobayashi, Michael Amoa-Bosompem, Katsunori Murota, Yukiko Higa, Hitoshi Kawada, Noboru Minakawa, Tran Chi Cuong, Nguyen Thi Yen, Tran Vu Phong, Sath Keo, Kroesna Kang, Kozue Miura, Lee Ching Ng, Hwa-Jen Teng, Samuel Dadzie, Sri Subekti, Kris Cahyo Mulyatno, Kyoko Sawabe, Takashi Tomita, Osamu Komagata
Summary: Aedes aegypti, the main mosquito vector for dengue and other arboviral infectious diseases, has developed high levels of pyrethroid resistance in populations collected from Vietnam and Cambodia. This resistance could pose a serious threat to the control of dengue fever and other Aedes-borne infectious diseases.
Article
Entomology
Alexander Soohoo-Hui, Zhilin Li, L. Paulina Maldonado-Ruiz, Ganyu Zhang, Daniel R. Swale
Summary: The study reveals that dopamine, serotonin, and pilocarpine increase the secretory activity of female A. aegypti salivary gland, while octopamine or ergonovine do not. Dopamine and serotonin exposure facilitate amylase secretion, with serotonin also increasing apyrase concentrations in the secreted saliva.
JOURNAL OF INSECT PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hitoshi Kawada, Yukiko Higa, Shinji Kasai
Summary: The extensive use of photostable 2nd generation pyrethroids for malaria and dengue vector control has led to widespread pyrethroid resistance in Aedes aegypti in southern Vietnam. The L982W mutation in the voltage-sensitive sodium channel has been identified as a significant cause of high-pyrethroid resistance in Vietnamese Ae. aegypti.
Article
Multidisciplinary Sciences
Talya Shragai, Juliana Perez-Perez, Marcela del Pilar Quimbayo-Forero, Raul Rojo, Laura C. Harrington, Guillermo Rua-Uribe
Summary: Dengue is becoming an increasing global threat in rapidly growing urban areas. This study analyzes nine years of dengue case data in Medellin, Colombia and finds that changes in accessibility and usage of public transit are correlated with changes in the spread and magnitude of localized outbreaks. Locations closer to and with greater utilization of public transit have higher dengue incidence, with a stronger effect observed in lower socioeconomic status areas. These results emphasize the importance of public health services in conjunction with urban growth.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Andrew S. Paige, Laura B. Duvall
Summary: A new study has discovered a mosquito salivary protein that binds directly to a cuticular partner during biting, leading to reshaping of the mosquito mouthparts, increased salivation and probing, and enhanced blood-feeding efficiency. By impacting mosquito-host interactions, this finding could have implications for pathogen transmission.
Article
Immunology
Yusnita Mirna Anggraeni, Triwibowo Ambar Garjito, Mega Tyas Prihatin, Sri Wahyuni Handayani, Kusumaningtyas Sekar Negari, Ary Oktsari Yanti, Muhammad Choirul Hidajat, Dhian Prastowo, Tri Baskoro Tunggul Satoto, Sylvie Manguin, Laurent Gavotte, Roger Frutos
Summary: Chikungunya virus has undergone a genotype replacement in Indonesia, with the Asian-Pacific genotype replacing the Asian genotype. The study raises questions about the mechanisms behind this rapid and massive replacement.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Parasitology
Lie Cheng, Wei-Liang Liu, Matthew P. Su, Shu-Chen Huang, Jen-Ren Wang, Chun-Hong Chen
Summary: In this study, we found that prohemocytes were the major type of hemocyte infected by DENV in both Ae. aegypti and Ae. albopictus. The infection rate of prohemocytes in Ae. albopictus was lower than that in Ae. aegypti, which may explain why systemic DENV infection in Ae. albopictus is less efficient than in Ae. aegypti and why Ae. albopictus is less correlated to dengue fever outbreaks.
PARASITES & VECTORS
(2022)
Article
Entomology
Eunice Nayeli Martinez-Garcia, Esteban E. Diaz-Gonzalez, Carlos F. Marina, J. Guillermo Bond, Jorge J. Rodriguez-Rojas, Gustavo Ponce-Garcia, Rosa M. Sanchez-Casas, Ildefonso Fernandez-Salas
Summary: Diseases transmitted by Aedes mosquitoes are a growing global concern. The Sterile Insect Technique (SIT) is a strategy for controlling mosquito populations, and egg storage is essential in SIT programs. This study found that two moisturizing substances, hydrolyzed collagen and Hyalurosmooth(R), can prolong the viability of Aedes mosquito eggs, showing promise in mass rearing insect production for vector control.
Article
Infectious Diseases
Audrey Lenhart, Carmen Elena Castillo, Elci Villegas, Neal Alexander, Veerle Vanlerberghe, Patrick van der Stuyft, Philip S. McCall
Summary: A large-scale trial in Venezuela found that the use of insecticide treated curtains and water jar covers can effectively control dengue vector populations, especially when used in combination.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Multidisciplinary Sciences
Emre Aksoy, Alexander S. Raikhel
Summary: The study identified a JH-mediated mechanism involving E75-RD in regulating miRNA gene expression, particularly the positive regulation of miRNAs such as miR-2940. Functional experiments confirmed the significant impact of miR-2940 on follicle development and egg production.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Parasitology
Chalida Sri-in, Aunyaratana Thontiravong, Lyric C. Bartholomay, Sonthaya Tiawsirisup
Summary: This study investigates the replication and transmission mechanism of duck Tembusu virus (DTMUV) in Aedes aegypti mosquitoes. The silencing of AaSG34 salivary protein significantly reduces DTMUV replication and transmission in mosquito salivary glands, while upregulating the expression of antimicrobial peptides.
