Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents
Authors
Keywords
-
Journal
Pharmaceutics
Volume 13, Issue 8, Pages 1169
Publisher
MDPI AG
Online
2021-07-30
DOI
10.3390/pharmaceutics13081169
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mechanism of Supersaturation Suppression in Dissolution Process of Acidic Drug Salt
- (2019) Jumpei Oki et al. MOLECULAR PHARMACEUTICS
- Utilization of In Vitro, In Vivo and In Silico Tools to Evaluate the pH-Dependent Absorption of a BCS Class II Compound and Identify a pH-Effect Mitigating Strategy
- (2019) Christoph Gesenberg et al. PHARMACEUTICAL RESEARCH
- Physiologically Based Absorption Modeling of Salts of Weak Bases Based on Data in Hypochlorhydric and Achlorhydric Biorelevant Media
- (2018) Filippos Kesisoglou et al. AAPS PHARMSCITECH
- Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective
- (2018) Mohamad Shebley et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Precipitation behavior of pioglitazone on the particle surface of hydrochloride salt in biorelevant media
- (2018) Taiga Uekusa et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Identification and characterisation of a salt form of Danirixin with reduced pharmacokinetic variability in patient populations
- (2017) Jackie C. Bloomer et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Model-Based Analysis of Biopharmaceutic Experiments To Improve Mechanistic Oral Absorption Modeling: An Integrated in Vitro in Vivo Extrapolation Perspective Using Ketoconazole as a Model Drug
- (2017) Shriram M. Pathak et al. MOLECULAR PHARMACEUTICS
- Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug – Drug Interaction Studies
- (2016) Chara Litou et al. PHARMACEUTICAL RESEARCH
- Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap® System
- (2015) Mirko Koziolek et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Biopharmaceutical classification of poorly soluble drugs with respect to “enabling formulations”
- (2013) Stephen Timothy Buckley et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Impaired Drug Absorption Due to High Stomach pH: A Review of Strategies for Mitigation of Such Effect To Enable Pharmaceutical Product Development
- (2013) Amitava Mitra et al. MOLECULAR PHARMACEUTICS
- An Investigation into the Utility of a Multi-compartmental, Dynamic, System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs
- (2012) Paul A. Dickinson et al. AAPS Journal
- Different effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6, CYP2C19 and CYP3A4
- (2012) Masato Ohbuchi et al. XENOBIOTICA
- Relative bioavailability of prasugrel free base in comparison to prasugrel hydrochloride in the presence and in the absence of a proton pump inhibitor
- (2011) Dan Seiler et al. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
- Using Absorption Simulation and Gastric pH Modulated Dog Model for Formulation Development To Overcome Achlorhydria Effect
- (2011) Amitava Mitra et al. MOLECULAR PHARMACEUTICS
- Population-Based Mechanistic Prediction of Oral Drug Absorption
- (2009) Masoud Jamei et al. AAPS Journal
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now