Utilization of In Vitro, In Vivo and In Silico Tools to Evaluate the pH-Dependent Absorption of a BCS Class II Compound and Identify a pH-Effect Mitigating Strategy

Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug – Drug Interaction Studies

(2016) Chara Litou et al.   PHARMACEUTICAL RESEARCH

Assessing the Risk of pH-Dependent Absorption for New Molecular Entities: A Novel in Vitro Dissolution Test, Physicochemical Analysis, and Risk Assessment Strategy

(2013) Neil R. Mathias et al.   MOLECULAR PHARMACEUTICS

Impaired Drug Absorption Due to High Stomach pH: A Review of Strategies for Mitigation of Such Effect To Enable Pharmaceutical Product Development

(2013) Amitava Mitra et al.   MOLECULAR PHARMACEUTICS

An Investigation into the Utility of a Multi-compartmental, Dynamic, System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs

(2012) Paul A. Dickinson et al.   AAPS Journal

The Use of Modeling Tools to Drive Efficient Oral Product Design

(2012) Neil R. Mathias et al.   AAPS Journal

Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy?

(2012) N R Budha et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Solid dispersions: a strategy for poorly aqueous soluble drugs and technology updates

(2012) Mohd Aftab Alam et al.   Expert Opinion on Drug Delivery

Development of a Canine Model to Enable the Preclinical Assessment of Ph-dependent Absorption of Test Compounds

(2011) R. Marcus Fancher et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Using Absorption Simulation and Gastric pH Modulated Dog Model for Formulation Development To Overcome Achlorhydria Effect

(2011) Amitava Mitra et al.   MOLECULAR PHARMACEUTICS

Dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs with poor water solubility

(2010) Phuong Ha-Lien Tran et al.   Expert Opinion on Drug Delivery

Physical Stability of Salts of Weak Bases in the Solid-State

(2010) Gregory A. Stephenson et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A pH-Dilution Method for Estimation of Biorelevant Drug Solubility along the Gastrointestinal Tract: Application to Physiologically Based Pharmacokinetic Modeling

(2010) Yi Gao et al.   MOLECULAR PHARMACEUTICS

Systematic review: impaired drug absorption related to the co-administration of antisecretory therapy

(2009) E. LAHNER et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pharmacokinetics and Absorption of Posaconazole Oral Suspension under Various Gastric Conditions in Healthy Volunteers

(2008) G. Krishna et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY