Novel Ex Vivo Zymography Approach for Assessment of Protease Activity in Tissues with Activatable Antibodies

Probody therapeutic design of 89Zr-CX-072 promotes accumulation in PD-L1 expressing tumors compared to normal murine lymphoid tissue

(2020) Danique Giesen et al.   CLINICAL CANCER RESEARCH

Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy

(2020) David G. Millar et al.   NATURE BIOTECHNOLOGY

Evidence of intratumoral localization, activation, and immunomodulatory effect of CX-072, a probody therapeutic targeting PD-L1, in a phase I/II trial.

(2020) Susan Lyman et al.   JOURNAL OF CLINICAL ONCOLOGY

Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling

(2020) Jesse D. Kirkpatrick et al.   Science Translational Medicine

Activity-Based Diagnostics: An Emerging Paradigm for Disease Detection and Monitoring

(2020) Ava P. Soleimany et al.   TRENDS IN MOLECULAR MEDICINE

Monitoring protease activity in biological tissues using antibody prodrugs as sensing probes

(2020) Olga Vasiljeva et al.   Scientific Reports

Multiplexed Probing of Proteolytic Enzymes Using Mass Cytometry-Compatible Activity-Based Probes

(2020) Marcin Poreba et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The multifaceted roles of tumor-associated proteases and harnessing their activity for prodrug activation

(2019) Olga Vasiljeva et al.   BIOLOGICAL CHEMISTRY

CX-072, a PD-L1 Probody therapeutic, as monotherapy in patients with advanced solid tumors: Preliminary results of PROCLAIM-CX-072.

(2019) Aung Naing et al.   JOURNAL OF CLINICAL ONCOLOGY

A coiled-coil masking domain for selective activation of therapeutic antibodies

(2019) Vivian H. Trang et al.   NATURE BIOTECHNOLOGY

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

(2019) Dangge Wang et al.   Science Immunology

Insights from capillary electrophoresis approaches for characterization of monoclonal antibodies and antibody drug conjugates in the period 2016–2018

(2019) Antony Lechner et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Renal clearable catalytic gold nanoclusters for in vivo disease monitoring

(2019) Colleen N. Loynachan et al.   Nature Nanotechnology

Probody Therapeutics: An Emerging Class of Therapies Designed to Enhance On-Target Effects with Reduced Off-Tumor Toxicity for Use in Immuno-Oncology

(2019) Karen A. Autio et al.   CLINICAL CANCER RESEARCH

Antibody prodrugs for cancer

(2019) W. Michael Kavanaugh   EXPERT OPINION ON BIOLOGICAL THERAPY

Principles and approaches for reproducible scoring of tissue stains in research

(2018) David K. Meyerholz et al.   LABORATORY INVESTIGATION

Ultrasensitive tumour-penetrating nanosensors of protease activity

(2017) Ester J. Kwon et al.   Nature Biomedical Engineering

In vivo imaging of protease activity by Probody therapeutic activation

(2016) Kenneth R. Wong et al.   BIOCHIMIE

Cutting-edge capillary electrophoresis characterization of monoclonal antibodies and related products

(2016) Rabah Gahoual et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Imaging Active Urokinase Plasminogen Activator in Prostate Cancer

(2015) A. M. LeBeau et al.   CANCER RESEARCH

Activity-Based Profiling of Proteases

(2014) Laura E. Sanman et al.   Annual Review of Biochemistry

Probody therapeutics for targeting antibodies to diseased tissue

(2014) Krishna R Polu et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Pericellular proteolysis in cancer

(2014) Lisa Sevenich et al.   GENES & DEVELOPMENT

Zymography methods for visualizing hydrolytic enzymes

(2013) Jennifer Vandooren et al.   NATURE METHODS

Tumor-Specific Activation of an EGFR-Targeting Probody Enhances Therapeutic Index

(2013) L. R. Desnoyers et al.   Science Translational Medicine

Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease

(2012) Gabriel A Kwong et al.   NATURE BIOTECHNOLOGY

Imaging a functional tumorigenic biomarker in the transformed epithelium

(2012) A. M. LeBeau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A Reverse Binding Motif That Contributes to Specific Protease Inhibition by Antibodies

(2011) Eric L. Schneider et al.   JOURNAL OF MOLECULAR BIOLOGY

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

(2011) Netta Sela-Passwell et al.   NATURE MEDICINE

Mechanisms of Macromolecular Protease Inhibitors

(2010) Christopher J. Farady  et al.   CHEMBIOCHEM

Serine proteases of the human immune system in health and disease

(2010) Kirstin M. Heutinck et al.   MOLECULAR IMMUNOLOGY

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspases in apoptosis and beyond

(2008) J Li et al.   ONCOGENE