Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy

VDR Agonists Increase Sensitivity of MCF-7 and BT-474 Breast Cancer Cells to 5 FU

(2020) DAGMARA KLOPOTOWSKA et al.   ANTICANCER RESEARCH

Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: A comparative, randomized, double-blind, placebo-controlled clinical trial

(2020) Tatul Saghatelyan et al.   PHYTOMEDICINE

β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways

(2020) Pengyu Su et al.   OncoTargets and Therapy

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers

(2019) Aarif Siddiqui et al.   CELL DEATH AND DIFFERENTIATION

Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial

(2019) Lynne M Howells et al.   JOURNAL OF NUTRITION

Methotrexate and Curcumin co-encapsulated PLGA nanoparticles as a potential breast cancer therapeutic system: In vitro and in vivo evaluation

(2019) Molood Alsadat Vakilinezhad et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Metronomic combination of vinorelbine and 5Fluorouracil inhibit triple-negative breast cancer cells results from the proof-of-concept VICTOR-0 study

(2018) Maria Grazia Cerrito et al.   Oncotarget

Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer

(2017) Kristin K. Brown et al.   Cancer Discovery

Folic acid conjugation improves the bioavailability and chemosensitizing efficacy of curcumin-encapsulated PLGA-PEG nanoparticles towards paclitaxel chemotherapy

(2017) Arun Kumar T. Thulasidasan et al.   Oncotarget

Inhibition of NF-κB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer

(2016) Balney Rajitha et al.   CANCER LETTERS

Curcumin Enhances the Effects of 5-Fluorouracil and Oxaliplatin in Inducing Gastric Cancer Cell Apoptosis Both In Vitro and In Vivo

(2016) Xiang Zhou et al.   ONCOLOGY RESEARCH

Curcumin inhibits B[a]PDE-induced procarcinogenic signals in lung cancer cells, and curbs B[a]P-induced mutagenesis and lung carcinogenesis

(2015) Vineshkumar T. Puliyappadamba et al.   BIOFACTORS

Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer

(2015) Shusuke Toden et al.   CARCINOGENESIS

DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria

(2015) Jayesh Antony et al.   Scientific Reports

Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures

(2014) Mehdi Shakibaei et al.   PLoS One

Activation of NFkB is a novel mechanism of pro-survival activity of glucocorticoids in breast cancer cells

(2013) Shagufta Khan et al.   CANCER LETTERS

Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil

(2013) B S Vinod et al.   Cell Death & Disease

India faces growing breast cancer epidemic

(2012) Priya Shetty   LANCET

Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells

(2011) W. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer

(2011) C N Sreekanth et al.   ONCOGENE

CoFactor: Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy

(2010) Muhammad Wasif Saif et al.   Journal of Oncology

AKT plays a pivotal role in the acquisition of resistance to 5-fluorouracil in human squamous carcinoma cells

(2009) You   Molecular Medicine Reports

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

(2008) Ajaikumar B. Kunnumakkara et al.   CANCER LETTERS