Article
Cell Biology
Zhengtong Lv, Jianlong Wang, Xuan Wang, Miao Mo, Guyu Tang, Haozhe Xu, Jianye Wang, Yuan Li, Ming Liu
Summary: A risk model containing nine ferroptosis-related genes was constructed in this study, demonstrating strong prognostic and therapeutic predictive power in prostate cancer. The higher risk score calculated by the model was significantly associated with adverse clinicopathological characteristics, immune infiltration, probability of biochemical recurrence, and treatment response in PCa. The findings provide new insights and potential clinical applications of ferroptosis in PCa.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zhi-Bin Ke, Qi You, Jiang-Bo Sun, Jun-Ming Zhu, Xiao-Dong Li, Dong-Ning Chen, Li Su, Qing-Shui Zheng, Yong Wei, Xue-Yi Xue, Ning Xu
Summary: This study successfully identified three ferroptosis-related molecular clusters and developed a novel ferroptosis-based molecular signature for predicting biochemical recurrence-free survival and tumor immune microenvironment of prostate cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Cheng Yang, Lei Chen, Qingsong Niu, Qintao Ge, Jiong Zhang, Junyue Tao, Jun Zhou, Chaozhao Liang
Summary: This study found that the E2F signaling pathway is associated with biochemical recurrence in prostate cancer (PCa). By establishing an E2F-related gene signature and nomogram, it is possible to accurately predict the biochemical recurrence in PCa.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Lizhe Zhu, Qi Tian, Siyuan Jiang, Huan Gao, Shibo Yu, Yudong Zhou, Yu Yan, Yu Ren, Jianjun He, Bin Wang
Summary: This study predicts the survival status of breast cancer patients using a ferroptosis-related gene signature and demonstrates that the signature can effectively predict the survival risk of patients. These findings provide valuable insights for personalized treatment of breast cancer in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Qin Liu, Jian-Ying Ma, Gaosong Wu
Summary: Utilizing a bioinformatics approach, a prognostic signature based on ferroptosis-related genes was established for predicting survival outcomes in breast cancer patients, showing significant differences in clinical features and treatment responses.
Article
Oncology
Gaohaer Kadeerhan, Bo Xue, Xiaolin Wu, Xiaofeng Hu, Jun Tian, Dongwen Wang
Summary: In this study, a robust 8-gene signature was established based on transcriptome profiles of prostate cancer for accurately predicting the risk of biochemical recurrence. PRAME, a risk-related gene, was found to be upregulated in high-risk prostate cancer samples and correlated with chemotherapeutic drug response. Knocking down PRAME reduced the proliferation, migration, and invasion of prostate cancer cells. This study provides a novel tool for stratifying high-risk prostate cancer patients and sheds light on the mechanism of prostate cancer progression.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Huaxiang Wang, Chengkai Yang, Yi Jiang, Huanzhang Hu, Jian Fang, Fang Yang
Summary: This study constructed a gene signature to predict the recurrence rate in hepatocellular carcinoma (HCC). A total of 39 ferroptosis-related genes were identified and used to construct a risk model. The results showed that this model accurately predicts recurrence after hepatectomy, providing novel research directions for personalized treatment in HCC patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chen Yang, Tian Yu, Qin Lin
Summary: This study aimed to investigate the role of anoikis in prostate cancer progression and develop a prognostic signature based on anoikis-related genes (ARGs). Nonnegative matrix factorization (NMF) analysis identified distinct patterns of anoikis modification, while single-sample gene-set enrichment analysis (ssGSEA) evaluated immune infiltration. Survival analysis and risk score generation using ARG expression levels quantitatively assessed the modification of anoikis. Four hub-genes were identified using the Least Absolute Shrinkage and Selection Operator (LASSO) method, and patients were classified into different risk groups based on their scores. The low-risk subtype had significantly improved biochemical recurrence-free survival, highlighting the clinical relevance of the ARG-based prognostic signature.
BIOCHEMICAL GENETICS
(2023)
Article
Medicine, General & Internal
Zichen Bian, Xinbo Huang, Yiding Chen, Jialin Meng, Xingliang Feng, Meng Zhang, Li Zhang, Jun Zhou, Chaozhao Liang
Summary: A fifteen-miRNA-based prediction signature was established to evaluate prognosis of prostate cancer patients by distinguishing risk levels and showing good predictive performance in different cohorts. Analysis of miRNA-mRNA network and pathways indicated enrichment of differences between two risk groups in tumor progression and drug resistance-related pathways.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Taisheng Liu, Honglian Luo, Jinye Zhang, Xiaoshan Hu, Jian Zhang
Summary: Through the analysis of ferroptosis-related genes, we established a signature with five genes to stratify NSCLC patients into high-risk and low-risk subgroups. Patients in the high-risk group had significantly lower overall survival, and the risk score was an independent predictor of prognosis. Functional analysis revealed enrichment of immune-related pathways associated with abnormal activation of immune cells.
Article
Oncology
Lilit Karapetyan, William Gooding, Aofei Li, Xi Yang, Andrew Knight, Hassan M. Abushukair, Danielle Vargas De Stefano, Cindy Sander, Arivarasan Karunamurthy, Monica Panelli, Walter J. Storkus, Ahmad A. Tarhini, John M. Kirkwood
Summary: Despite negative sentinel lymph node status, patients with Stage IIB/IIC melanoma have poor melanoma-specific survival. This study identified a novel 12-gene sentinel lymph node signature risk score that can predict disease recurrence in melanoma patients, regardless of sentinel lymph node status.
Article
Oncology
Xiaodong Zhao, Zuheng Wang, Zilu Tang, Jun Hu, Yulin Zhou, Jingping Ge, Jie Dong, Song Xu
Summary: This study proposes a novel approach to predict postoperative biochemical recurrence in prostate cancer patients through a signature based on anoikis-related genes (ARGs). Specific ARGs in prostate cancer were identified using data from TCGA-PARD and GEO databases, and a prognostic signature of these ARGs was established. The signature demonstrates potential as a biomarker for prostate cancer prognosis and treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
A. Jun, Baotong Zhang, Zhiqian Zhang, Hailiang Hu, Jin-Tang Dong
Summary: Molecular signatures predictive of recurrence-free survival and castration resistance in prostate cancer are crucial for treatment decisions, but current signatures have limited robustness. By analyzing 287 differentially expressed genes, a 6-gene signature called CRPC-derived prognosis signature (CRPCPS) was identified to predict recurrence-free survival and distinguish between castration-resistant and hormone-sensitive prostate cancer. The robustness of this signature was demonstrated in multiple cohorts, showing its potential clinical utility.
Article
Oncology
Tian-cheng Cheng, Jia-hao Wu, Bei Zhu, Hai-yan Gao, Lin Zheng, Wei-xian Chen
Summary: In this study, a five-gene signature including BCL2, SLC40A1, TFF1, APOOL, and PRAME was established for prognostic prediction in breast cancer. The signature showed good performance in survival prediction and was associated with cancer progression, immune infiltration, immune response, and drug resistance.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jiajian Hu, Fengju Song, Wenjuan Kang, Fantong Xia, Zi'an Song, Yangyang Wang, Jie Li, Qiang Zhao
Summary: A ferroptosis-related gene signature was constructed to predict the outcomes and evaluate the effects of immunotherapy for neuroblastoma.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Computer Science, Information Systems
Kai Zhang, Jiao Tian, Hongwang Xiao, Ying Zhao, Wenyu Zhao, Jinjun Chen
Summary: Blockchain has attracted attention from the IoT research community due to its decentralization and consistency. However, the accessibility of all nodes to the chain data raises privacy concerns. To address this issue, we propose a novel LDP mechanism that splits and perturbs input numerical data using digital bits, without requiring a fixed input range and large data volume. Our adaptive privacy budget allocation model significantly reduces the deviation of the perturbation function and provides high data utility while maintaining privacy.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Article
Oncology
Tao Zhang, Bofang Wang, Baohong Gu, Fei Su, Lin Xiang, Le Liu, Xuemei Li, Xueyan Wang, Lei Gao, Hao Chen
Summary: This research systematically analyzed the molecular alterations and clinical relevance of histone acetyltransferase (HAT) and histone deacetylase (HDAC) genes in five types of digestive cancers. It found recurrent mutations and copy number variations in acetylation-associated genes, and identified their correlation with cancer hallmark-related pathways. The expression pattern of these genes stratified patients' clinical benefit in hepatocellular carcinoma and pancreatic cancer.
JOURNAL OF ONCOLOGY
(2022)
Article
Orthopedics
Jing Liu, Xiaodong Cheng, Yan Wang, Ping Zhang, Lei Gao, Xingyuan Yang, Shaoqiang He, Ying Liu, Wei Zhang
Summary: The study explored the VD angle of L1 in elderly women and its impact on vertebral stiffness using QCT-FEA. Results showed a slight increase in VD angle with age, moderate negative correlation between age and VS, and no correlation between VD angle and vBMD. Vertebral stiffness gradually decreased with higher VD angle, and fracture risk increased when load was perpendicular to the lower edge of the vertebral body.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Immunology
Kai Zhang, Lei Gao, Hai-xu Wang, Lei Ye, Yan-yan Shi, Wu-yan Yang, Ya-nan Li, Yan Li
Summary: The study found that IL-18 expression levels were significantly increased in NP tissues of both IVDD patients and mouse models. Treatment with Ad-sh-IL-18 reversed IVDD progression in mice models and increased levels of Aggrecan and Collagen II in NP cells. Ad-sh-IL-18 was also found to inhibit NP cell apoptosis by regulating the caspase-3/9 pathway.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Medicine, Research & Experimental
Jing Liu, Yan-Yan Hu, Qiu-Yan Zhang, Ya-Nan Zhang, Na Li, Zhe-Rui Zhang, Shun-Li Zhan, Lei Gao, Cheng-Lin Deng, Xiao-Dan Li, Shao-Peng Yuan, Yuan-Qiao He, Han-Qing Ye, Bo Zhang
Summary: Ideal oncolytic viruses have been found, including WNV-poly(A), which can selectively kill tumor cells and activate the immune response, making it a potential novel oncolytic agent against various types of cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell & Tissue Engineering
Li Han, Lei Dong, Keith Leung, Zhicong Zhao, Yangchan Li, Lei Gao, Zhenhua Chen, Jianhuang Xue, Ying Qing, Wei Li, Sheela Pangeni Pokharel, Min Gao, Meiling Chen, Chao Shen, Brandon Tan, Andrew Small, Kitty Wang, Zheng Zhang, Xi Qin, Lu Yang, Mark Wunderlich, Bin Zhang, James C. Mulloy, Guido Marcucci, Chun-Wei Chen, Minjie Wei, Rui Su, Jianjun Chen, Xiaolan Deng
Summary: This study reveals that N6-methyladenosine (m6A), the most prevalent internal modification in mammalian mRNAs, is involved in many pathological processes. METTL16, a recently identified m6A methyltransferase, plays a crucial role in the survival of acute myeloid leukemia (AML) cells.
Review
Oncology
Na Wang, Ewetse Paul Maswikiti, Bofang Wang, Yang Yu, Yanling Ma, Lin Xiang, Chenhui Ma, Zhen Ma, Baohong Gu, Lei Gao, Hao Chen
Summary: Describes a case of a patient with oesophageal cancer who underwent successful surgery using ICG imaging fluorescence laparoscopy, leading to a good recovery outcome. Demonstrates the importance and feasibility of fluorescence laparoscopy in patients with oesophageal cancer.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Hematology
Matthew Mei, Lu Chen, James Godfrey, Joo Song, Colt Egelston, Sandrine Puverel, Elizabeth Budde, Saro Armenian, Liana Nikolaenko, Mary Nwangwu, Weihua Guo, Lei Gao, Peter Lee, Robert Chen, Shari Daniels, Neena Kennedy, Lacolle Peters, Jasmine Zain, Steven Rosen, Stephen Forman, Leslie Popplewell, Larry Kwak, Alex F. Herrera
Summary: This phase 1 study evaluated the addition of vorinostat to pembrolizumab in patients with follicular lymphoma. The study found that the combination therapy had a high overall response rate in patients with relapsed classical Hodgkin's lymphoma.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingyuan Yang, Ying Liu, Jing Liu, Lei Gao, Ping Zhang, Yan Wang, Wei Zhang
Summary: The study aims to explore the feasibility of the 9 zonal trabecular vBMD method for evaluating the first lumbar vertebral body (L1) in women aged 50-80 years and assess the distribution of trabecular vBMD in different zones of L1. The results showed no significant differences in vBMDs among the 9 zones and a negative correlation between age and global vBMD as well as the 9 zonal vBMDs. In terms of vBMD, the posterior region had higher density than the anterior region, and the foot and head regions had higher density than the middle region.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hong Yu, Lei Gao, Ruiqing Shi, Mengjuan Kong, Lisha Duan, Jianling Cui
Summary: This study aimed to predict early responses to neoadjuvant chemotherapy (NACT) in patients with primary conventional osteosarcoma (COS) using the apparent diffusion coefficient (ADC) and evaluate factors affecting the tumor necrosis rate (TNR). Data from 41 patients who underwent magnetic resonance imaging (MRI) and diffusion-weighted imaging scans were prospectively collected. The results showed that ADC2, ADC3, ADC3-1, ADC3-2, and alkaline phosphatase (ALP) before NACT were significantly higher in the good-response group than in the poor-response group. ADC2, ADC3, and ADC3-1 showed good diagnostic performance. However, multivariate analysis showed no significant correlation between these parameters and TNR.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongwei Yu, Yiping Ouyang, Yibo Feng, Shilong Sun, Linwei Zhang, Zunjing Liu, Hong Tian, Sheng Xie
Summary: This study compared the application of single postlabeling delay (PLD) 3-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) and 7-delay 3D-pCASL magnetic resonance imaging in patients with intracranial atherosclerotic stenosis. The results showed that there were inconsistencies between single-PLD 3D-pCASL and 7-delay 3D-pCASL in the assessment of cerebral blood flow (CBF). Moreover, the perfusion parameters generated under the standard single-PLD 3D-pCASL were more affected by arterial transit time (ATT).
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Zhicong Zhao, Ying Qing, Lei Dong, Li Han, Dong Wu, Yangchan Li, Wei Li, Jianhuang Xue, Keren Zhou, Miao Sun, Brandon Tan, Zhenhua Chen, Chao Shen, Lei Gao, Andrew Small, Kitty Wang, Keith Leung, Zheng Zhang, Xi Qin, Xiaolan Deng, Qiang Xia, Rui Su, Jianjun Chen
Summary: The mRNA internal m7G modification is recognized by Quaking proteins (QKIs), which regulate mRNA stability and translation, affecting cellular drug resistance.
Article
Cell Biology
Yang Yu, Yidian Wang, Dayong Xi, Na Wang, Lei Gao, Qianling Shi, Rong Yu, Haiyuan Li, Lin Xiang, Ewetse Paul Maswikiti, Hao Chen
Summary: We developed an adenosine-based prognostic signature for gastric cancer and explored its association with tumor immune response. The signature showed significant differences in overall survival between high-risk and low-risk patients, and was found to be associated with immunosuppressive states and poor immunotherapy response. This signature represents a promising tool for risk stratification and individualized prognostication in gastric cancer.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Developmental Biology
Chitkale Hiremath, Lei Gao, Kenya Geshow, Quinten Patterson, Haley Barlow, Ondine Cleaver, Denise K. Marciano
Summary: The presence of a continuous lumen in renal tubules is essential for their proper function. In this study, we found that the protein Afadin, which binds to Factin, is required for lumen formation and continuity in renal tubules derived from the nephrogenic mesenchyme in mice. We also discovered that the small GTPase Rap1 plays a crucial role in this process, as its absence leads to severe defects in lumen formation. Furthermore, we observed that Rap1 is necessary for the correct localization of Afadin to adherens junctions. These findings suggest a model in which Rap1 localizes Afadin to junctional complexes, thereby regulating lumen formation and positioning.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Baiwang Ding, Sifan Zhou, Zhoujian Wang, Wei Liu, Lei Gao, Yani Ding, Hua Huang, Qixing Zhu, Jiaxiang Zhang
Summary: Trichloroethylene (TCE) induces occupational medicamentosa-like dermatitis due to TCE (OMDT) with immune liver injury, and TNF-α plays an important role in macrophage polarization and liver injury. This study aimed to investigate the regulatory effects of TNF-α on macrophage polarization and autophagy in TCE-induced liver injury. The results showed that TNF-α/TNFR1 promoted M1 polarization of macrophages and suppressed macrophage autophagy via the mTOR pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
