Article
Cell Biology
Lizhe Zhu, Qi Tian, Siyuan Jiang, Huan Gao, Shibo Yu, Yudong Zhou, Yu Yan, Yu Ren, Jianjun He, Bin Wang
Summary: This study predicts the survival status of breast cancer patients using a ferroptosis-related gene signature and demonstrates that the signature can effectively predict the survival risk of patients. These findings provide valuable insights for personalized treatment of breast cancer in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuxuan Wang, Weikang Chen, Minqi Zhu, Lei Xian
Summary: This study constructed a gene signature related to ferroptosis for predicting the prognosis of LUAD patients. It also revealed a potential connection between ferroptosis and tumor-infiltrating immune cells in LUAD patients.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Qi Tian, Yan Zhou, Lizhe Zhu, Huan Gao, Jin Yang
Summary: The study explores the prognostic value of ferroptosis-related genes in lung adenocarcinoma (LUAD) and develops a ferroptosis-related prognostic signature based on 7 core prognostic differentially expressed genes (DEGs). This signature can effectively predict the survival of LUAD patients, suggesting that targeting ferroptosis may be a potential therapeutic alternative for LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Anran Zhang, Jinpo Yang, Chao Ma, Feng Li, Huan Luo
Summary: This study established a novel 15-gene signature related to ferroptosis, which accurately predicts the prognosis of LUAD and is associated with specific immune cells. The findings demonstrate the independent prognostic value of this gene signature in patients with LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Shuai Ping, Siyuan Wang, Yingsong Zhao, Jinbing He, Guanglei Li, Dinglin Li, Zhuo Wei, Jianghai Chen
Summary: This study developed a robust signature with ferroptosis-related genes and assessed its ability to predict overall survival in patients with skin cutaneous melanoma. The signature showed higher prediction efficiency than clinicopathological features and was associated with immune pathways and immunosuppression in melanoma.
Article
Biology
Haifeng Li, Lu Li, Cong Xue, Riqing Huang, Anqi Hu, Xin An, Yanxia Shi
Summary: Ferroptosis is an iron-dependent cell death mechanism related to various human diseases, including breast cancer. By establishing an 8-gene model, researchers can predict breast cancer patients' prognosis, leading to stratification of patients into high- and low-risk groups for better treatment and care. The model also shows potential in providing valuable insights for clinical settings in the future.
Article
Oncology
Xinliang Gao, Mingbo Tang, Suyan Tian, Jialin Li, Wei Liu
Summary: This study established a novel ferroptosis-related gene signature for predicting overall survival in LUAD patients, and revealed differences in immune status between high-risk and low-risk groups. Targeting ferroptosis may be a potential therapeutic option in LUAD.
Article
Multidisciplinary Sciences
Xinliang Gao, Mingbo Tang, Suyan Tian, Jialin Li, Wei Liu
Summary: A novel circadian gene signature for predicting overall survival in LUAD patients was identified in this study. The five-gene signature was found to be significantly associated with overall survival and may serve as a potential therapeutic target in LUAD.
Article
Cell Biology
Bo Xiao, Liyan Liu, Zhuoyuan Chen, Aoyu Li, Yu Xia, Pingxiao Wang, Cheng Xiang, Yi Zeng, Hui Li
Summary: This study identified a novel prognostic marker based on stem cell-related genes for osteosarcoma patients, independent of other clinical traits. The marker was validated to be significant in predicting survival rate and providing potential therapeutic targets. The research suggests that the expression level of stem cell-related genes could serve as valuable prognostic markers and therapeutic targets for osteosarcoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Huan Liu, Lei Gao, Tiancheng Xie, Jie Li, Ting-shuai Zhai, Yunfei Xu
Summary: This study investigated ferroptosis related genes in prostate cancer and identified seven FRGs to establish a risk model. The high-risk group was associated with various clinical characteristics, and overexpression of TFRC gene was found to be related to PCa cell proliferation and invasion.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lei Wang, Zixuan Wu, Chen Xu, Hang Ye
Summary: This study highlights the important role of ferroptosis-related genes (FRGs) in the pathogenesis and progression of pancreatic adenocarcinoma (PAAD). FRGs are upregulated in high-risk patients and are associated with immune and tumor-related pathways. Differences in immune function and RNA modification are observed between low-risk and high-risk groups. Additionally, several genes are identified as crucial mediators in PAAD pathogenesis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemical Research Methods
Guo-Sheng Li, Hui-Ping Lu, Li Gao, Jian-Di Li, Rong-Quan He, Hua-Fu Zhou, Shang-Wei Chen, Jun Liu, Zong-Wang Fu, Jin-Liang Kong, Jiang-Hui Zeng, Juan He, Gang Chen
Summary: This study established a prognostic signature for lung adenocarcinoma (LUAD) patients based on pyroptosis-related genes (PRGs), including CASP3, CASP9, GSDMB, NLRP1, and TNF. The prognostic effect of the signature was evident in predicting the one-, three-, and five-year survival rates of LUAD patients. The signature risk score could predict the prognosis of LUAD patients more accurately than PRGs and multiple clinical parameters.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Medicine, General & Internal
Lu Yuan, Zijun Lu, Guoqiang Sun, Dongmei Cao
Summary: This study aims to establish an effective molecular model to assess the prognosis of patients with cervical cancer (CC) and guide clinical treatment to improve their survival rate. Through bioinformatic analysis, a 4-gene signature was developed to predict the overall survival (OS) of CC. These findings may be beneficial for individualized clinical treatment and timely follow-up.
Article
Oncology
Tian-cheng Cheng, Jia-hao Wu, Bei Zhu, Hai-yan Gao, Lin Zheng, Wei-xian Chen
Summary: In this study, a five-gene signature including BCL2, SLC40A1, TFF1, APOOL, and PRAME was established for prognostic prediction in breast cancer. The signature showed good performance in survival prediction and was associated with cancer progression, immune infiltration, immune response, and drug resistance.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Yan Zhang, Yiran Liang, Yajie Wang, Fangzhou Ye, Xiaoli Kong, Qifeng Yang
Summary: Breast cancer, the most prevalent cancer among women worldwide, presents a challenge for treatment and prognosis due to its heterogeneous nature. This study identified nine genes associated with prognosis in breast cancer patients and developed a risk score formula. The study also established a nomogram that showed powerful predictive ability. Functional analysis revealed a connection between ferroptosis and breast cancer progression and drug resistance.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)