Evolution of CD8+ T Cell Receptor (TCR) Engineered Therapies for the Treatment of Cancer

TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers

(2021) Nisha B. Nagarsheth et al.   NATURE MEDICINE

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma

(2021) Giacomo Oliveira et al.   NATURE

Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations

(2021) Fenge Li et al.   Journal for ImmunoTherapy of Cancer

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

(2020) S. Depil et al.   NATURE REVIEWS DRUG DISCOVERY

Very rapid cloning, expression and identifying specificity of T-cell receptors for T-cell engineering

(2020) Shan Zong et al.   PLoS One

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

The Emerging Landscape of Immune Cell Therapies

(2020) Evan W. Weber et al.   CELL

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

(2020) Daniel K. Wells et al.   CELL

Overcoming key challenges in cancer immunotherapy with engineered T cells

(2020) Silvia Arcangeli et al.   CURRENT OPINION IN ONCOLOGY

Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers

(2020) Sherille D. Bradley et al.   Nature Communications

TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals

(2020) Francesco Manfredi et al.   Frontiers in Immunology

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

(2019) Winifred Lo et al.   Cancer Immunology Research

T cell antigen discovery via trogocytosis

(2019) Guideng Li et al.   NATURE METHODS

Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy

(2019) Anthony Tanoto Tan et al.   GASTROENTEROLOGY

Synthetic T cell receptor-based lymphocytes for cancer therapy

(2019) Daniel Getts et al.   ADVANCED DRUG DELIVERY REVIEWS

Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors

(2019) Fangjun Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

(2019) Markus W. Löffler et al.   Genome Medicine

Discovery and characterization of actionable tumor antigens

(2019) Grégory Ehx et al.   Genome Medicine

Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses

(2019) Anthony E. Zamora et al.   Science Translational Medicine

Engineered T Cell Therapy for Cancer in the Clinic

(2019) Lijun Zhao et al.   Frontiers in Immunology

Application of mass spectrometry-based MHC immunopeptidome profiling in neoantigen identification for tumor immunotherapy

(2019) Xiaomei Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma

(2019) Deepak Perumal et al.   CLINICAL CANCER RESEARCH

A large peptidome dataset improves HLA class I epitope prediction across most of the human population

(2019) Siranush Sarkizova et al.   NATURE BIOTECHNOLOGY

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes

(2018) Marvin H. Gee et al.   CELL

Identification of α-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy

(2018) Wei Zhu et al.   HEPATOLOGY

Driving T-cell immunotherapy to solid tumors

(2018) Ken Garber   NATURE BIOTECHNOLOGY

Dynamic changes during the treatment of pancreatic cancer

(2018) Robert A. Wolff et al.   Oncotarget

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

Actively personalized vaccination trial for newly diagnosed glioblastoma

(2018) Norbert Hilf et al.   NATURE

Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells

(2017) Daniel T. MacLeod et al.   MOLECULAR THERAPY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Therapeutic T cell engineering

(2017) Michel Sadelain et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

(2017) Yinmeng Yang et al.   Science Translational Medicine

Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   Molecular Therapy-Methods & Clinical Development

HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer

(2017) Kendra C. Foley et al.   Molecular Therapy-Oncolytics

Delivery of foreign cytotoxic T lymphocyte epitopes to tumor tissues for effective antitumor immunotherapy against pre-established solid tumors in mice

(2016) Herbert W. Kavunja et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

T-cell adoptive immunotherapy using tumor-infiltrating T cells and genetically engineered TCR-T cells: Table 1.

(2016) Hiroaki Ikeda   INTERNATIONAL IMMUNOLOGY

Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System

(2016) Drew C Deniger et al.   MOLECULAR THERAPY

Gene Insertion Into Genomic Safe Harbors for Human Gene Therapy

(2016) Eirini P Papapetrou et al.   MOLECULAR THERAPY

Prospects for gene-engineered T cell immunotherapy for solid cancers

(2016) Christopher A Klebanoff et al.   NATURE MEDICINE

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

(2016) Alena Gros et al.   NATURE MEDICINE

Cancer immunotherapy targeting neoantigens

(2016) Yong-Chen Lu et al.   SEMINARS IN IMMUNOLOGY

An optimized single chain TCR scaffold relying on the assembly with the native CD3-complex prevents residual mispairing with endogenous TCRs in human T-cells

(2016) Diana Knies et al.   Oncotarget

Rapid tumor regression in an Asian lung cancer patient following personalized neo-epitope peptide vaccination

(2016) Fenge Li et al.   OncoImmunology

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

Adoptive T-cell therapy for cancer: The era of engineered T cells

(2015) Chiara Bonini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice

(2015) Matthias Obenaus et al.   NATURE BIOTECHNOLOGY

NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma

(2015) Aaron P Rapoport et al.   NATURE MEDICINE

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

(2014) Y.-C. Lu et al.   CLINICAL CANCER RESEARCH

Survivin-specific T cell receptor targets tumor but not T cells

(2014) Caroline Arber et al.   JOURNAL OF CLINICAL INVESTIGATION

Requirements for Effective Antitumor Responses of TCR Transduced T Cells

(2014) M. A. de Witte et al.   JOURNAL OF IMMUNOLOGY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

(2013) H. Torikai et al.   BLOOD

HLA ligandome tumor antigen discovery for personalized vaccine approach

(2013) Hans-Georg Rammensee et al.   Expert Review of Vaccines

Sleeping Beauty System to Redirect T-cell Specificity for Human Applications

(2013) Sourindra N. Maiti et al.   JOURNAL OF IMMUNOTHERAPY

Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy

(2013) Richard A. Morgan et al.   JOURNAL OF IMMUNOTHERAPY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy

(2013) Maria Themeli et al.   NATURE BIOTECHNOLOGY

High-throughput identification of antigen-specific TCRs by TCR gene capture

(2013) Carsten Linnemann et al.   NATURE MEDICINE

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

(2013) Paul F Robbins et al.   NATURE MEDICINE

MHC Multimer-Guided and Cell Culture-Independent Isolation of Functional T Cell Receptors from Single Cells Facilitates TCR Identification for Immunotherapy

(2013) Georg Dössinger et al.   PLoS One

Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells

(2013) B. J. Cameron et al.   Science Translational Medicine

Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies

(2013) G. L. Beatty et al.   Cancer Immunology Research

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR

(2012) H. Torikai et al.   BLOOD

Exploiting the glioblastoma peptidome to discover novel tumour-associated antigens for immunotherapy

(2012) Valérie Dutoit et al.   BRAIN

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

Mutated BCR-ABL Generates Immunogenic T-cell Epitopes in CML Patients

(2012) A. Cai et al.   CLINICAL CANCER RESEARCH

Isolation of human MHC class II-restricted T cell receptors from the autologous T-cell repertoire with potent anti-leukaemic reactivity

(2012) Luise U Weigand et al.   IMMUNOLOGY

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

(2012) Hirokazu Matsushita et al.   NATURE

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

(2012) Elena Provasi et al.   NATURE MEDICINE

Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains

(2011) D H Aggen et al.   GENE THERAPY

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

(2011) Antonio Di Stasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular immunology lessons from therapeutic T-cell receptor gene transfer

(2010) Sharyn Thomas et al.   IMMUNOLOGY

Transgenic mice with a diverse human T cell antigen receptor repertoire

(2010) Liang-Ping Li et al.   NATURE MEDICINE

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

(2010) Gavin M Bendle et al.   NATURE MEDICINE

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

Improved Expression and Reactivity of Transduced Tumor-Specific TCRs in Human Lymphocytes by Specific Silencing of Endogenous TCR

(2009) S. Okamoto et al.   CANCER RESEARCH

Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer

(2009) K Birkholz et al.   GENE THERAPY

Rapid αβ TCR-mediated responses in γδ T cells transduced with cancer-specific TCR genes

(2009) A Hiasa et al.   GENE THERAPY

Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition

(2008) S Yang et al.   GENE THERAPY

AAV Vector-mediated Reversal of Hypoglycemia in Canine and Murine Glycogen Storage Disease Type Ia

(2008) Dwight D Koeberl et al.   MOLECULAR THERAPY