Systemic T Cell Exhaustion Dynamics Is Linked to Early High Mobility Group Box Protein 1 (HMGB1) Driven Hyper-Inflammation in a Polytrauma Rat Model

Targeting Inflammation Driven by HMGB1

(2020) Huan Yang et al.   Frontiers in Immunology

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

(2020) Nathalie Percie du Sert et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Burn and thoracic trauma alters fracture healing, systemic inflammation, and leukocyte kinetics in a rat model of polytrauma

(2019) Lauren H. Mangum et al.   Journal of Orthopaedic Surgery and Research

Reparative T lymphocytes in organ injury

(2019) Franco R. D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

Biphasic Release of the Alarmin High Mobility Group Box 1 Protein Early After Trauma Predicts Poor Clinical Outcome

(2019) William Ottestad et al.   CRITICAL CARE MEDICINE

Damage-associated molecular patterns in trauma

(2019) Borna Relja et al.   European Journal of Trauma and Emergency Surgery

Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury

(2018) Ying Shao et al.   ANTIOXIDANTS & REDOX SIGNALING

The diagnostic value of early cytokine response in patients after major trauma – preliminary report

(2018) Aneta M. Binkowska et al.   Central European Journal of Immunology

Impact of haemorrhagic shock intensity on the dynamic of alarmins release in porcine poly-trauma animal model

(2015) K. Horst et al.   European Journal of Trauma and Emergency Surgery

Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b+Gr-1+Myeloid-Derived Suppressor Cells Require HMGB1

(2015) Xiangcai Ruan et al.   MEDIATORS OF INFLAMMATION

Trauma-Induced Coagulopathy Is Associated with a Complex Inflammatory Response in the Rat

(2015) Daniel N. Darlington et al.   SHOCK

HMGB1 Enhances Immune Suppression by Facilitating the Differentiation and Suppressive Activity of Myeloid-Derived Suppressor Cells

(2014) K. H. Parker et al.   CANCER RESEARCH

Inflammatory and apoptotic alterations in serum and injured tissue after experimental polytrauma in mice

(2013) Sebastian Weckbach et al.   Journal of Trauma and Acute Care Surgery

Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent Pathways

(2013) Shiqin Sun et al.   PLoS One

Terminally Differentiated CD8+ T Cells Negatively Affect Bone Regeneration in Humans

(2013) S. Reinke et al.   Science Translational Medicine

Up-regulation of mitofusin-2 protects CD4+ T cells from HMGB1-mediated immune dysfunction partly through Ca2+-NFAT signaling pathway

(2012) Guang-ju Zhao et al.   CYTOKINE

HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells

(2012) Clarissa Anni Wild et al.   INTERNATIONAL IMMUNOLOGY

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

Mixed antagonist response and sepsis severity-dependent dysbalance of pro- and anti-inflammatory responses at the onset of postoperative sepsis

(2011) Alexander R. Novotny et al.   IMMUNOBIOLOGY

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Diagnosis-Dependent Relationships between Cytokine Levels and Survival in Patients Admitted for Surgical Critical Care

(2010) Tjasa Hranjec et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

THE EFFECT OF HIGH-MOBILITY GROUP BOX 1 PROTEIN ON ACTIVITY OF REGULATORY T CELLS AFTER THERMAL INJURY IN RATS

(2009) Li-feng Huang et al.   SHOCK

Management of lower limb fractures in polytrauma patients with delayed referral in a mass disaster

(2008) Shabir Ahmed Dhar et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Th1- and Th2-Type Cytokines in Plasma After Major Trauma

(2008) Oleg Heizmann et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE