The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization

Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation

(2021) Laleh Abbassi et al.   Nature Communications

Evolutionary, proteomic, and experimental investigations suggest the extracellular matrix of cumulus cells mediates fertilization outcomes

(2021) Sara Keeble et al.   BIOLOGY OF REPRODUCTION

Lysophosphatidic acid improves oocyte quality during IVM by activating the ERK1/2 pathway in cumulus cells and oocytes

(2021) Yerong Ma et al.   MOLECULAR HUMAN REPRODUCTION

Effect of bisphenol A on alterations of ICAM-1 and HLA-G genes expression and DNA methylation profiles in cumulus cells of infertile women with poor response to ovarian stimulation

(2021) Somayeh Aftabsavad et al.   Scientific Reports

Effects of Early Cumulus Cell Removal on Treatment Outcomes in Patients Undergoing In Vitro Fertilization: A Retrospective Cohort Study

(2021) Pengcheng Kong et al.   Frontiers in Endocrinology

Versican expression level in cumulus cells is associated with human oocyte developmental competence

(2020) Qiuzi Shen et al.   Systems Biology in Reproductive Medicine

Versican G1 Fragment Establishes a Strongly Stabilized Interaction with Hyaluronan-Rich Expanding Matrix during Oocyte Maturation

(2020) Eva Nagyova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation

(2020) David C. Briggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of survivin induces spindle disorganization, chromosome misalignment, and DNA damage during mouse embryo development

(2020) Meng-Hao Pan et al.   CELL CYCLE

Three-dimensional organization of transzonal projections and other cytoplasmic extensions in the mouse ovarian follicle

(2019) Valentina Baena et al.   Scientific Reports

Matrix metalloproteinases and their inhibitors in human cumulus and granulosa cells as biomarkers for oocyte quality estimation

(2018) Alice Luddi et al.   FERTILITY AND STERILITY

Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

(2018) M. G. Da Broi et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Effect of pre-in vitro maturation with cAMP modulators on the acquisition of oocyte developmental competence in cattle

(2018) Satoshi SUGIMURA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

GDF9 and BMP15 induce development of antrum-like structures by bovine granulosa cells without oocytes

(2018) Md Hasanur ALAM et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Atrazine suppresses FSH-induced steroidogenesis and LH-dependent expression of ovulatory genes through PDE-cAMP signaling pathway in human cumulus granulosa cells

(2018) Kristina Pogrmic-Majkic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Assessing ICSI outcome by combining non-invasive indicators: early time-lapse morphokinetics and apoptosis in associated cumulus cells among women with the polycystic ovarian syndrome

(2018) Nasim Tabibnejad et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Is there a correlation between follicle size and gene expression in cumulus cells and is gene expression an indicator of embryo development?

(2018) Semra Kahraman et al.   Reproductive Biology and Endocrinology

Differential long non-coding RNA expression profiles in human oocytes and cumulus cells

(2018) Julien Bouckenheimer et al.   Scientific Reports

Metabolomic profiles of bovine cumulus cells and cumulus-oocyte-complex-conditioned medium during maturation in vitro

(2018) Karen Uhde et al.   Scientific Reports

GDF-9 and BMP-15 direct the follicle symphony

(2018) Alexandra Sanfins et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The mitochondrial DNA content of cumulus cells may help predict embryo implantation

(2018) A. Taugourdeau et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Association between early embryo morphokinetics plus cumulus cell gene expression and assisted reproduction outcomes in polycystic ovary syndrome women

(2018) Nasim Tabibnejad et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Cumulus cells surrounding oocytes with high developmental competence exhibit down-regulation of phosphoinositol 1,3 kinase/protein kinase B (PI3K/AKT) signalling genes involved in proliferation and survival

(2017) P G Artini et al.   HUMAN REPRODUCTION

Genome-wide interactions between FSH and insulin-like growth factors in the regulation of human granulosa cell differentiation

(2017) Carlos Stocco et al.   HUMAN REPRODUCTION

Levels of cyclic-AMP and cyclic-GMP in porcine oocyte-cumulus complexes and cumulus-free oocytes derived from small and middle follicles during the first 24-hour period of in vitro maturation

(2017) Yuichi OKUDAIRA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis

(2017) Anika V. Prabhu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Prostaglandin E2 stimulates the expression of cumulus expansion-related genes in pigs: the role of protein kinase B

(2017) Milan Blaha et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

The dynamic pattern of PLIN3 in pig oocytes and cumulus cells during in vitro maturation

(2017) Mingzhu Xu et al.   ZYGOTE

Embryo quality predictive models based on cumulus cells gene expression

(2016) R Devjak et al.   Balkan Journal of Medical Genetics

The beneficial effects of cumulus cells and oocyte-cumulus cell gap junctions depends on oocyte maturation and fertilization methods in mice

(2016) Cheng-Jie Zhou et al.   PeerJ

Cumulus Cell-Expressed Type I Interferons Induce Cumulus Expansion in Mice1

(2015) You-Jee Jang et al.   BIOLOGY OF REPRODUCTION

Transcriptomic Diversification of Developing Cumulus and Mural Granulosa Cells in Mouse Ovarian Follicles1

(2015) Karen Wigglesworth et al.   BIOLOGY OF REPRODUCTION

Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health

(2015) Daniel A. Dumesic et al.   FERTILITY AND STERILITY

Correlation of cumulus gene expression of GJA1, PRSS35, PTX3, and SERPINE2 with oocyte maturation, fertilization, and embryo development

(2015) Sheng-Hsiang Li et al.   Reproductive Biology and Endocrinology

Specific gene expression differences in cumulus cells as potential biomarkers of pregnancy

(2015) Tanja Burnik Papler et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Increased New lncRNA–mRNA Gene Pair Levels in Human Cumulus Cells Correlate With Oocyte Maturation and Embryo Development

(2015) Juan Li et al.   Reproductive Sciences

IGF1R Signaling Is Necessary for FSH-Induced Activation of AKT and Differentiation of Human Cumulus Granulosa Cells

(2014) Sarah C. Baumgarten et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Increased GDF9 and BMP15 mRNA levels in cumulus granulosa cells correlate with oocyte maturation, fertilization, and embryo quality in humans

(2014) Yi Li et al.   Reproductive Biology and Endocrinology

Follicle growth, ovulation, and luteal formation in primates and rodents: A comparative perspective

(2013) Charles L Chaffin et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Comparison of gene expression profiles in granulosa and cumulus cells after ovulation induction with either human chorionic gonadotropin or a gonadotropin-releasing hormone agonist trigger

(2013) Tanni Borgbo et al.   FERTILITY AND STERILITY

Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions

(2013) J. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+ mobilization in cumulus cells: Role in oocyte maturation and acrosome reaction

(2012) Hui Chen et al.   CELL CALCIUM

New candidate genes to predict pregnancy outcome in single embryo transfer cycles when using cumulus cell gene expression

(2012) Sandra Wathlet et al.   FERTILITY AND STERILITY

Signaling pathways regulating FSH- and amphiregulin-induced meiotic resumption and cumulus cell expansion in the pig

(2012) R Prochazka et al.   REPRODUCTION

Human cumulus cell gene expression as a biomarker of pregnancy outcome after single embryo transfer

(2011) Kathryn Michelle Gebhardt et al.   FERTILITY AND STERILITY

Cumulus cell gene expression predicts better cleavage-stage embryo or blastocyst development and pregnancy for ICSI patients

(2011) S. Wathlet et al.   HUMAN REPRODUCTION

Prediction of oocyte developmental competence in ovine using glucose-6-phosphate dehydrogenase (G6PDH) activity determined at retrieval time

(2011) Abdollah Mohammadi-Sangcheshmeh et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis

(2011) Eva Nagyova et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

ADAMTS1 Cleavage of Versican Mediates Essential Structural Remodeling of the Ovarian Follicle and Cumulus-Oocyte Matrix During Ovulation in Mice1

(2010) Hannah M. Brown et al.   BIOLOGY OF REPRODUCTION

Growth differentiation factor 9 signaling requires ERK1/2 activity in mouse granulosa and cumulus cells

(2010) M. Sasseville et al.   JOURNAL OF CELL SCIENCE

The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome

(2010) Zhongwei Huang et al.   MOLECULAR HUMAN REPRODUCTION

Human cumulus cells as biomarkers for embryo and pregnancy outcomes

(2010) S. Assou et al.   MOLECULAR HUMAN REPRODUCTION

PACAP-mediated sperm–cumulus cell interaction promotes fertilization

(2010) Ichiro Tanii et al.   REPRODUCTION

Regulation of Gap Junctions in Porcine Cumulus-Oocyte Complexes: Contributions of Granulosa Cell Contact, Gonadotropins, and Lipid Rafts

(2009) Maxime Sasseville et al.   MOLECULAR ENDOCRINOLOGY

Mouse Oocyte Control of Granulosa Cell Development and Function: Paracrine Regulation of Cumulus Cell Metabolism

(2009) You-Qiang Su et al.   SEMINARS IN REPRODUCTIVE MEDICINE