Melatonin, a Potential Therapeutic Agent for Preeclampsia, Reduces the Extrusion of Toxic Extracellular Vesicles from Preeclamptic Placentae

Endoplasmic reticulum stress occurs in association with the extrusion of toxic extracellular vesicles from human placentae treated with antiphospholipid antibodies

(2020) Yunhui Tang et al.   CLINICAL SCIENCE

Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms

(2020) Luiz Gustavo de Almeida Chuffa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Placental small extracellular vesicles: Current questions and investigative opportunities

(2020) Yoel Sadovsky et al.   PLACENTA

Antiphospholipid Antibodies and Extracellular Vesicles in Pregnancy

(2020) Mancy Tong et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases

(2020) Andreea Iulia Socaciu et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Protein Misfolding during Pregnancy: New Approaches to Preeclampsia Diagnostics

(2019) Elizaveta M. Gerasimova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ER stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant

(2018) Paraskevi Kritsiligkou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia

(2018) Sebastian R Hobson et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia

(2018) Natalie J. Hannan et al.   PLoS One

The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice

(2018) Mark A. Brown et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Placental Nano-vesicles Target to Specific Organs and Modulate Vascular Tone In Vivo

(2017) Mancy Tong et al.   HUMAN REPRODUCTION

Melatonin prevents preeclamptic sera and antiphospholipid antibodies inducing the production of reactive nitrogen species and extrusion of toxic trophoblastic debris from first trimester placentae

(2017) Mingzhi Zhao et al.   PLACENTA

Placental trophoblast debris mediated feto-maternal signalling via small RNA delivery: implications for preeclampsia

(2017) Jia Wei et al.   Scientific Reports

Syncytiotrophoblast derived extracellular vesicles transfer functional placental miRNAs to primary human endothelial cells

(2017) Tina Cronqvist et al.   Scientific Reports

Micro- and Nano-vesicles from First Trimester Human Placentae Carry Flt-1 and Levels Are Increased in Severe Preeclampsia

(2017) Mancy Tong et al.   Frontiers in Endocrinology

Aggregated transthyretin is specifically packaged into placental nano-vesicles in preeclampsia

(2017) Mancy Tong et al.   Scientific Reports

Proteomic characterization of macro-, micro- and nano-extracellular vesicles derived from the same first trimester placenta: relevance for feto-maternal communication

(2016) Mancy Tong et al.   HUMAN REPRODUCTION

The reduction in circulating levels of melatonin may be associated with the development of preeclampsia

(2016) K Zeng et al.   JOURNAL OF HUMAN HYPERTENSION

Trophoblastic debris modifies endothelial cell transcriptome in vitro: a mechanism by which fetal cells might control maternal responses to pregnancy

(2016) J. Wei et al.   Scientific Reports

Potential Utility of Melatonin in Preeclampsia, Intrauterine Fetal Growth Retardation, and Perinatal Asphyxia

(2015) Lucia Marseglia et al.   Reproductive Sciences

Molecular mechanisms of maternal vascular dysfunction in preeclampsia

(2015) Styliani Goulopoulou et al.   TRENDS IN MOLECULAR MEDICINE

Antioxidant responses and cellular adjustments to oxidative stress

(2015) Cristina Espinosa-Diez et al.   Redox Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction

(2014) Suzanne L. Miller et al.   JOURNAL OF PINEAL RESEARCH

Trophoblast debris extruded from preeclamptic placentae activates endothelial cells: A mechanism by which the placenta communicates with the maternal endothelium

(2014) F. Shen et al.   PLACENTA

Tumor Necrosis Factor-Alpha, Interleukin-6, and Interleukin-10 Levels are Altered in Preeclampsia: A Systematic Review and Meta-Analysis

(2013) Sien Yee Lau et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Detection and quantification of endoplasmic reticulum stress in living cells using the fluorescent compound, Thioflavin T

(2013) Daniel R. Beriault et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology

(2013) Russel J. Reiter et al.   HUMAN REPRODUCTION UPDATE

Antiphospholipid antibodies internalised by human syncytiotrophoblast cause aberrant cell death and the release of necrotic trophoblast debris

(2013) Chez A. Viall et al.   JOURNAL OF AUTOIMMUNITY

Calcium channel blockers prevent endothelial cell activation in response to necrotic trophoblast debris: possible relevance to pre-eclampsia

(2012) Q. Chen et al.   CARDIOVASCULAR RESEARCH

Placental melatonin production and melatonin receptor expression are altered in preeclampsia: new insights into the role of this hormone in pregnancy

(2012) Dave Lanoix et al.   JOURNAL OF PINEAL RESEARCH

Serum melatonin levels and antioxidant capacities after consumption of pineapple, orange, or banana by healthy male volunteers

(2012) Manit Sae-Teaw et al.   JOURNAL OF PINEAL RESEARCH

Antioxidant Therapies: A Potential Role in Perinatal Medicine

(2012) S.L. Miller et al.   NEUROENDOCRINOLOGY

Oxidative stress

(2010) Graham J. Burton et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Anti-phospholipid Antibodies Increase Non-apoptotic Trophoblast Shedding: A Contribution to the Pathogenesis of Pre-eclampsia in Affected Women?

(2009) Q. Chen et al.   PLACENTA

IL-6, TNFα and TGFβ Promote Nonapoptotic Trophoblast Deportation and Subsequently Causes Endothelial Cell Activation

(2009) L.M. Chen et al.   PLACENTA

A role for interleukin-6 in spreading endothelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia

(2008) Q Chen et al.   JOURNAL OF PATHOLOGY

Human placental trophoblasts synthesize melatonin and express its receptors

(2008) Dave Lanoix et al.   JOURNAL OF PINEAL RESEARCH