Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells

Assessing the importance of interleukin-6 in COVID-19

(2021) Luke Y C Chen et al.   Lancet Respiratory Medicine

Assessing the importance of interleukin-6 in COVID-19 – Authors' reply

(2021) Daniel E Leisman et al.   Lancet Respiratory Medicine

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

(2021) Wilfredo F. Garcia-Beltran et al.   CELL

Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody

(2021) Simon Gebremeskel et al.   Frontiers in Immunology

The role of IL-6 and IL-6 blockade in COVID-19

(2021) Nicola Potere et al.   Expert Review of Clinical Immunology

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

(2021) Robert W. Malone et al.   Frontiers in Pharmacology

SARS-CoV-2 evolution and vaccines: cause for concern?

(2021) Thomas C Williams et al.   Lancet Respiratory Medicine

Compounds with therapeutic potential against novel respiratory 2019 coronavirus

(2020) Miguel Angel Martinez   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IL-4 Enhances Interferon Production by Virus-Infected Human Mast Cells

(2020) Liliana Portales-Cervantes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

(2020) Peter Richardson et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia: case series

(2020) Achille Aouba et al.   ANNALS OF THE RHEUMATIC DISEASES

Recovery from COVID-19 in a patient with spondyloarthritis treated with TNF-alpha inhibitor etanercept

(2020) Pierre-Marie Duret et al.   ANNALS OF THE RHEUMATIC DISEASES

Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns

(2020) Stephen J. Galli et al.   Annual Review of Immunology

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

(2020) Francesca Coperchini et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

(2020) Chi Zhang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Safety and efficacy of early high-dose IV anakinra in severe COVID-19 lung disease

(2020) Emanuele Pontali et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact

(2020) Fabrizio Cantini et al.   JOURNAL OF INFECTION

Tocilizumab for the treatment of severe coronavirus disease 2019

(2020) Rand Alattar et al.   JOURNAL OF MEDICAL VIROLOGY

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

(2020) Dandan Wu et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

The COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmaco-Immunomodulatory Therapy in COVID-19

(2020) John G. Rizk et al.   DRUGS

Lessons for COVID-19 Immunity from Other Coronavirus Infections

(2020) Alan Sariol et al.   IMMUNITY

Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up

(2020) Lang Wang et al.   JOURNAL OF INFECTION

ACE2 and COVID-19: using antihypertensive medications and pharmacogenetic considerations

(2020) Eric M Snyder et al.   PHARMACOGENOMICS

ACE2 and COVID-19 and the resulting ARDS

(2020) Xiaoqing Zhang et al.   POSTGRADUATE MEDICAL JOURNAL

Is a “Cytokine Storm” Relevant to COVID-19?

(2020) Pratik Sinha et al.   JAMA Internal Medicine

The COVID-19 Cytokine Storm; What We Know So Far

(2020) Dina Ragab et al.   Frontiers in Immunology

Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action

(2020) Hassan Yousefi et al.   BIOCHEMICAL PHARMACOLOGY

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Protective and pathogenic roles for mast cells during viral infections

(2020) Abhay PS Rathore et al.   CURRENT OPINION IN IMMUNOLOGY

The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions

(2020) Tapan Behl et al.   LIFE SCIENCES

Tackling the cytokine storm in COVID-19, challenges and hopes

(2020) Shifaa M. Abdin et al.   LIFE SCIENCES

Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches

(2020) Magda Gioia et al.   BIOCHEMICAL PHARMACOLOGY

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

(2020) Erik Volz et al.   CELL

Type I Interferon α/β Receptor-Mediated Signaling Negatively Regulates Antiviral Cytokine Responses in Murine Bone-Marrow-Derived Mast Cells and Protects the Cells from Virus-Induced Cell Death

(2020) Maedeh Darzianiazizi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

(2020) Bina Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Harnessing the Power of Mast Cells in unconventional Immunotherapy Strategies and Vaccine Adjuvants

(2020) Steven Willows et al.   Cells

Potential association of mast cells with coronavirus disease 2019

(2020) Theoharis C. Theoharides   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Clazakizumab in late antibody-mediated rejection: study protocol of a randomized controlled pilot trial

(2019) Farsad Eskandary et al.   Trials

Chitosan Plus Compound 48/80: Formulation and Preliminary Evaluation as a Hepatitis B Vaccine Adjuvant

(2019) Dulce Bento et al.   Pharmaceutics

Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis

(2019) Mercé Albert-Bayo et al.   Cells

Altered mast cell activity in response to rhinovirus infection provides novel insight into asthma

(2019) Haiwen Liu et al.   JOURNAL OF ASTHMA

The Role of Interleukin 6 During Viral Infections

(2019) Lauro Velazquez-Salinas et al.   Frontiers in Microbiology

Tocilizumab for the treatment of chimeric antigen receptor T cell-induced cytokine release syndrome

(2019) Chelsea Kotch et al.   Expert Review of Clinical Immunology

Thymoquinone Inhibits Neurogenic Inflammation Underlying Migraine Through Modulation of Calcitonin Gene-Related Peptide Release and Stabilization of Meningeal Mast Cells in Glyceryltrinitrate-Induced Migraine Model in Rats

(2019) Erkan Kilinc et al.   INFLAMMATION

The JAK1/JAK2- inhibitor ruxolitinib inhibits mast cell degranulation and cytokine release

(2018) M.A.W. Hermans et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Non-IgE mediated mast cell activation

(2018) Frank A. Redegeld et al.   IMMUNOLOGICAL REVIEWS

Mast cells signal their importance in health and disease

(2018) Ana Olivera et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin

(2018) Alexandra Taracanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anakinra Therapy for Non-cancer Inflammatory Diseases

(2018) Giulio Cavalli et al.   Frontiers in Pharmacology

Activation-induced upregulation of MMP9 in mast cells is a positive feedback mediator for mast cell activation

(2017) Lin Xu et al.   Molecular Medicine Reports

SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors

(2017) Alexandra Taracanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast cell chymase promotes hypertrophic scar fibroblast proliferation and collagen synthesis by activating TGF‑β1/Smads signaling pathway

(2017) Hongming Chen et al.   Experimental and Therapeutic Medicine

Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era

(2017) Edward M. Behrens et al.   Arthritis & Rheumatology

The Anti-allergic Cromones: Past, Present, and Future

(2017) Ajantha Sinniah et al.   Frontiers in Pharmacology

Mast cell stabilisers

(2016) Tao Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mast Cell: A Multi-Functional Master Cell

(2016) Melissa Krystel-Whittemore et al.   Frontiers in Immunology

Protease inhibitors targeting coronavirus and filovirus entry

(2015) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Olopatadine Inhibits Exocytosis in Rat Peritoneal Mast Cells by Counteracting Membrane Surface Deformation

(2015) Asuka Baba et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The therapeutic effects of sodium cromoglycate against influenza A virus H5N1 in mice

(2015) Deping Han et al.   Influenza and Other Respiratory Viruses

The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells

(2015) Zuyi Weng et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast-Cell-Derived TNF Amplifies CD8+ Dendritic Cell Functionality and CD8+ T Cell Priming

(2015) Jan Dudeck et al.   Cell Reports

Cross-protection against influenza virus infection by intranasal administration of nucleoprotein-based vaccine with compound 48/80 adjuvant

(2015) Mei Zheng et al.   Human Vaccines & Immunotherapeutics

Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)

(2014) Joachim Sieper et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-6 targeting compared to TNF targeting in rheumatoid arthritis: studies of olokizumab, sarilumab and sirukumab

(2014) Yoshiya Tanaka et al.   ANNALS OF THE RHEUMATIC DISEASES

Ketotifen in the management of chronic urticaria: resurrection of an old drug

(2013) Kristin C. Sokol et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor

(2013) Michail Alevizos et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Twenty-first century mast cell stabilizers

(2013) D F Finn et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intranasal Immunization of Mice with Inactivated Virus and Mast Cell Activator C48/80 Elicits Protective Immunity against Influenza H1 but not H5

(2013) Lili Xu et al.   IMMUNOLOGICAL INVESTIGATIONS

Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-α and IL-6 Production

(2013) Rui Aoki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mast Cell-Induced Lung Injury in Mice Infected with H5N1 Influenza Virus

(2012) Y. Hu et al.   JOURNAL OF VIROLOGY

Evidence questioning cromolyn’s effectiveness and selectivity as a ‘mast cell stabilizer’ in mice

(2012) Tatsuya Oka et al.   LABORATORY INVESTIGATION

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans

(2012) Zuyi Weng et al.   PLoS One

A Novel Imidazo[1,5-b]isoquinolinone Derivative, U63A05, Inhibits Syk Activation in Mast Cells to Suppress IgE-Mediated Anaphylaxis in Mice

(2011) Do Kyun Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Intranasal Immunization with Recombinant HA and Mast Cell Activator C48/80 Elicits Protective Immunity against 2009 Pandemic H1N1 Influenza in Mice

(2011) Shu Meng et al.   PLoS One

A New Class of Human Mast Cell and Peripheral Blood Basophil Stabilizers that Differentially Control Allergic Mediator Release

(2010) Sarah K. Norton et al.   CTS-Clinical and Translational Science

Olopatadine: a drug for allergic conjunctivitis targeting the mast cell

(2010) Andrea Leonardi et al.   EXPERT OPINION ON PHARMACOTHERAPY

Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Influenza Virus

(2010) H. Kayamuro et al.   JOURNAL OF VIROLOGY

G-Protein-Coupled Receptor 35 Is a Target of the Asthma Drugs Cromolyn Disodium and Nedocromil Sodium

(2010) Yuhua Yang et al.   PHARMACOLOGY

Mast Cells Augment Adaptive Immunity by Orchestrating Dendritic Cell Trafficking through Infected Tissues

(2009) Christopher P. Shelburne et al.   Cell Host & Microbe

Rupatadine Inhibits Proinflammatory Mediator Secretion from Human Mast Cells Triggered by Different Stimuli

(2009) Magdalini Vasiadi et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Anti-allergic effects of scoparone on mast cell-mediated allergy model

(2009) Y.H. Choi et al.   PHYTOMEDICINE

Suppression of the Antigen-Stimulated RBL-2H3 Mast Cell Activation by Artekeiskeanol A

(2009) JangJa Hong et al.   PLANTA MEDICA

Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFα release from canine skin mast cells

(2009) S. Cerrato et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism

(2008) S. M. Burke et al.   BLOOD

Interferon and cytokine responses to SARS-coronavirus infection

(2008) Volker Thiel et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Inhibitory effects of parthenolide on antigen-induced microtubule formation and degranulation in mast cells

(2008) Naoko Miyata et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Adelmidrol, a palmitoylethanolamide analogue, reduces chronic inflammation in a carrageenin-granuloma model in rats

(2008) Daniele De Filippis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mast cell activators: a new class of highly effective vaccine adjuvants

(2008) James B McLachlan et al.   NATURE MEDICINE

Mast cell renin and a local renin-angiotensin system in the airway: Role in bronchoconstriction

(2008) A. Veerappan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA