Article
Oncology
Qiushi Tang, Shuo Yang, Guangpeng He, Hongyu Zheng, Sheng Zhang, Jiaxing Liu, Shibo Wei, Qing Fan, Xueqiang Peng, Xinyu Li, Dewei Zhang, Liang Yang, Hangyu Li
Summary: Tumor-derived exosomes (TDEs) play a critical role in regulating the immune microenvironment of tumors and have the ability to suppress immune responses, thus impacting the effectiveness of cancer therapy. By delivering suppressive factors to immune cells, TDEs directly or indirectly influence immune cell function and antitumor activities. TDE-based therapy is emerging as a promising strategy for inhibiting tumor progression and enhancing antitumor immunity.
Review
Immunology
Lifei Liang, Xiaoqing Xu, Jiawei Li, Cheng Yang
Summary: This review summarizes and discusses the bidirectional regulation between miRNAs and MDSCs in the tumor microenvironment, revealing the impact of miRNAs and MDSCs on tumor immune escape and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Suwen Bai, Zunyun Wang, Minghua Wang, Junai Li, Yuan Wei, Ruihuan Xu, Juan Du
Summary: Tumor-derived exosomes play a critical role in tumor metastasis by transporting proteins and RNA, promoting migration, and influencing interactions with normal cells like vascular endothelial cells and immune cells. Their function in facilitating tumor metastasis underlines the importance of further research in this area.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Joel E. J. Beaumont, Nicky A. Beelen, Lotte Wieten, Kasper M. A. Rouschop
Summary: Hypoxia, a characteristic of many cancer types, can suppress the antitumor functions of the adaptive and innate immune system. Tumor-cell-derived extracellular vesicles (EVs), which participate in the communication between tumor cells and immune cells, are also affected by hypoxia and may contribute to immunosuppression. This review summarizes the current understanding of hypoxic cancer-cell-derived EVs in immunosuppression and provides an overview of the factors (miRNA and proteins) enriched in hypoxic tumor-derived EVs and their role in immunomodulation.
Article
Biochemistry & Molecular Biology
Jihye Hong, Mungyo Jung, Cheesue Kim, Mikyung Kang, Seokhyeong Go, Heesu Sohn, Sangjun Moon, Sungpil Kwon, Seuk Young Song, Byung-Soo Kim
Summary: Researchers have developed a personalized vaccine derived from tumor cells, which activates the immune system to target and destroy cancer cells. The vaccine, carrying a diverse mix of antigens, effectively inhibits tumor growth and improves survival rates. This approach could lead to the development of individually tailored cancer vaccines.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Engineering, Environmental
Min Yang, Li Pu, Shuiyue Yang, Ze Chen, Jia Guo, Ying Liu, Shuzhuo Chang, Yinghua Peng
Summary: Immunotherapy is a promising approach for tumor treatment, but the immunosuppressive tumor microenvironment is a major obstacle. In this study, engineered exosomes derived from antler stem cells were used to reverse the immunosuppressive tumor microenvironment and enhance tumor immunotherapy. The combination with a PD-L1 antibody showed a synergistic effect in preventing tumor progression and metastasis.
CHEMICAL ENGINEERING JOURNAL
(2024)
Review
Pharmacology & Pharmacy
Shumin Luo, Jing Chen, Fang Xu, Huan Chen, Yiru Li, Weihua Li
Summary: This article summarizes a new approach in cancer immunotherapy, which is based on the exosomes derived from dendritic cells (DEXs). DEXs have the potential to improve therapeutic outcomes and overcome tumor cell-mediated immunosuppression. By capturing tumor antigens and promoting immune cell-dependent tumor rejection, DEXs play an important role in enhancing immune responses and overcoming immune escape by tumors.
Article
Engineering, Biomedical
Chunxiang Feng, Zhiyong Xiong, Cheng Wang, Wen Xiao, Haibing Xiao, Kairu Xie, Ke Chen, Huageng Liang, Xiaoping Zhang, Hongmei Yang
Summary: The novel exosome-based drug delivery system designed in this study effectively degrades high molecular weight hyaluronan and modifies the immune microenvironment, reducing tumor cell metastasis.
BIOACTIVE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Ya-Nan Pi, Bai-Rong Xia, Ming-Zhu Jin, Wei-Lin Jin, Ge Lou
Summary: Cancer immunotherapy targeting the tumor immune microenvironment is considered revolutionary, with exosomes playing a crucial role in mediating intercellular communication and possibly serving as an adjuvant therapeutic strategy for immune-based combination therapy.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Cell Biology
Seyed Z. Rasihashemi, Erfan Rezazadeh Gavgani, Reza Majidazar, Parya Seraji, Mobina Oladghaffari, Tohid Kazemi, Parisa Lotfinejad
Summary: The article discusses the potential mechanism of exosomal PD-L1 in immune checkpoint therapy failure and explores the inhibition of exosome biogenesis as a new strategy to overcome tumor resistance to anti-PD-L1 therapy. The diagnostic and prognostic value of exosomal PD-L1 in different cancer types is also discussed.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Immunology
Ye Jin, Jianming Xing, Kejin Xu, Da Liu, Yue Zhuo
Summary: Exosomes, produced by endosomes, play a crucial role in intercellular communication. Over the past few decades, there has been growing recognition of the importance of exosomes in the tumor microenvironment and their connection to cancer development. This paper discusses the composition, generation, uptake, and roles of exosomes in tumor metastasis, angiogenesis, and immunosuppression. Understanding the biological characteristics of exosomes and their functions in tumor development is significant for identifying new diagnostic biomarkers and therapeutic targets for cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ziyin Chen, Ziqi Yue, Ronghua Wang, Kaiqi Yang, Shenglong Li
Summary: Cancer is the leading cause of death worldwide and a major obstacle to increasing life expectancy. Recent developments in nanotechnology have brought breakthroughs in cancer immunotherapy, using engineered nanomaterials to trigger specific tumor-killing effects and improve immune cell infiltration into metastatic lesions, leading to a more effective immune response and preventing metastasis and tumor recurrence.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Emily M. Ploeg, Xiurong Ke, Isabel Britsch, Mark A. J. M. Hendriks, Femke A. Van der Zant, Schelto Kruijff, Douwe F. Samplonius, Hao Zhang, Wijnand Helfrich
Summary: This study introduced a novel bispecific antibody CD73xEpCAM, which selectively inhibits CD73 exposed on tumor-derived EVs, reducing their immunosuppressive effects and offering a potential new approach for cancer immunotherapy.
Article
Genetics & Heredity
Alejandro Pando, Christoph Schorl, Loren D. Fast, John L. Reagan
Summary: Extracellular vesicles (EVs), which are lipid bilayer particles containing various substances, are excreted from all cells in the human body. In this study, researchers investigated the effects of acute myeloid leukemia (AML)-derived EVs on gene expression levels in three different T cell populations, finding that these EVs modulate gene expression and significantly impact immunoregulatory pathways.
Review
Cell Biology
Qi-Hui Xie, Ji-Qi Zheng, Jia-Yi Ding, Yu-Fei Wu, Luisa Liu, Zi-Li Yu, Gang Chen
Summary: Exosomes are membranous structures secreted by various cell types and serve as critical messengers for intercellular communication. In the tumor microenvironment, exosomes exert immunosuppressive effects, influencing tumor development and the effectiveness of immunotherapy. Therapeutic strategies targeting the molecular mechanism of exosome-mediated tumor development may overcome immune tolerance and contribute to innovative treatments.
Article
Dermatology
Anais Zanella, Valentin Vautrot, Francois Aubin, Laure Avoscan, Mahtab Samimi, Carmen Garrido, Jessica Gobbo, Charlee Nardin
Summary: Exosomes, as potential biomarkers, have attracted interest in oncology. PD-L1 was found in circulating exosomes of MCC patients and tended to be higher in advanced disease. However, Exo-PD-L1 levels were similar to healthy donors and lower than other cancers. Changes in Exo-PD-L1 levels were not significant over the course of the disease.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Chemistry, Medicinal
Suwen Hu, Zi Hui, Jilong Duan, Carmen Garrido, Tian Xie, Xiang-Yang Ye
Summary: ATR kinase is an important target for anticancer therapy, and its structural features and patent space have been analyzed in this article. Clinical investigations of ATR inhibitors employ both monotherapy and combination therapy, with diverse structures achieving good ATR inhibitory activity and selectivity. Currently, eight ATR inhibitors are being evaluated in clinics, aiming for approval in the near future.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2022)
Article
Oncology
Mohammed I. Y. Elmallah, Pablo Ortega-Deballon, Laure Hermite, Jean-Paul Pais-De-Barros, Jessica Gobbo, Carmen Garrido
Summary: Strong evidence suggests that the molecular composition of lipids in exosomes varies depending on the cell type and plays a role in cancer initiation and progression. This study found changes in lipid species in exosomes derived from different cell lines and confirmed these changes in patients. Certain lipid species were increased in primary cancer patients and nonmetastatic cells, while decreased in metastatic conditions. These findings highlight the potential use of lipid biomarkers for the diagnosis of different stages of colorectal cancer.
MOLECULAR ONCOLOGY
(2022)
Article
Cell Biology
Aleksandra Georgievski, Anais Michel, Charles Thomas, Zandile Mlamla, Jean-Paul Pais de Barros, Stephanie Lemaire-Ewing, Carmen Garrido, Ronan Quere
Summary: This study demonstrates that extracellular vesicles (EVs) produced by proliferative acute lymphoblastic leukemia (ALL) cells can specifically target hematopoietic stem and progenitor cells (HSPC), influencing their quiescence and maintenance. The researchers discovered that ALL EVs are enriched in cholesterol and other metabolites that promote mitochondrial function in targeted HSPC. These findings provide insights into a new oncogenic mechanism and its impact on a healthy hematopoiesis system during leukemia development.
CELL DEATH & DISEASE
(2022)
Editorial Material
Clinical Neurology
Jorge Matias-Guiu, Jordi A. Matias-Guiu, Carmen Garrido, Genaro Pimienta, Patricio F. Reyes, Abdul Mannan Baig, Ulises Gomez-Pinedo
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Maeva Wendremaire, Tatiana E. Lopez, Marina Barrichon, Hang Zhang, Tarik Hadi, Xiang-Yang Ye, Fabrice Neiers, Marc Bardou, Paul Sagot, Carmen Garrido, Frederic Lirussi
Summary: This study evaluated the effects of leptin on myometrial contraction and differentiation using a co-culture model of human primary macrophages and myocytes. The results showed that leptin had different effects on myocytes and macrophages depending on the dose, and a low concentration of leptin inhibits myocyte contraction, differentiation, and macrophage-induced reactive oxygen species (ROS) production. Leptin also increased the expression of HLA-G, suggesting its tocolytic effect may be driven by HLA-G.
Article
Biochemistry & Molecular Biology
Baptiste Dumetier, Aymeric Zadoroznyj, Jean Berthelet, Sebastien Causse, Jennifer Allegre, Pauline Bourgeois, Florine Cattin, Cindy Racoeur, Catherine Paul, Carmen Garrido, Laurence Dubrez
Summary: Cellular inhibitor of apoptosis-1 (cIAP1) is a signaling regulator involved in the regulation of multiple signaling pathways and has oncogenic properties. It interacts with the molecular adaptor TRAF2 to form signaling complexes and promotes tumor growth through the activation of the JAK/STAT3 pathway.
Review
Oncology
Vincent Cabaud-Gibouin, Manon Durand, Ronan Quere, Francois Girodon, Carmen Garrido, Gaetan Jego
Summary: Heat-shock proteins (HSPs) are molecular chaperones that are overexpressed in tumor cells and play a crucial role in their survival. In leukemia and lymphoma, HSPs have been found to have distinctive cytoprotective effects on various cell death and growth pathways. This review examines the implications of HSPs in these pathways in hematological malignancies and discusses the importance of detecting and targeting them for future innovative treatment strategies.
Article
Chemistry, Medicinal
Julie Tanguy, Pierre-Marie Boutanquoi, Olivier Burgy, Lucile Dondaine, Guillaume Beltramo, Burhan Uyanik, Carmen Garrido, Philippe Bonniaud, Pierre-Simon Bellaye, Francoise Goirand
Summary: In this study, we discovered that inhibiting HSPB5 with NCI-41356 could limit pulmonary fibrosis by reducing the accumulation of collagen and pro-fibrotic markers. This effect is likely mediated through the inhibition of HSPB5/SMAD4 interaction and modulation of SMAD4 and TGF-beta 1 signaling. Further investigations are needed to determine the translatability of these results to humans.
Review
Biochemistry & Molecular Biology
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Rami Aqeilan, Eli Arama, Eric H. Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A. Barlev, Jiri Bartek, Nicolas G. Bazan, Christoph Becker, Francesca Bernassola, Mathieu J. M. Bertrand, Marco E. Bianchi, Mikhail V. Blagosklonny, J. Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D. Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A. Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K-M Chan, Guo-Qiang Chen, Quan Chen, Youhai H. Chen, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D'Angiolella, Mads Daugaard, Ted M. Dawson, Valina L. Dawson, Ruggero De Maria, Bart De Strooper, Klaus-Michael Debatin, Ralph J. Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J. Dixon, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J. Garcia-Saez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Georg Haecker, Gyorgy Hajnoczky, J. Marie Hardwick, Ygal Haupt, Sudan He, David M. Heery, Michael O. Hengartner, Claudio Hetz, David A. Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jaeaettelae, Ana Janic, Bertrand Joseph, Philipp J. Jost, Thirumala-Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L. Kelly, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Ruth Kluck, Dmitri Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N. Lavrik, John J. Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos Lopez-Otin, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean-Christophe Marine, Seamus J. Martin, Jean-Claude Martinou, Pier G. Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A. Miao, Ute M. Moll, Cristina Munoz-Pinedo, Daniel J. Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Nunez, Andrew Oberst, Dimitry Ofengeim, Joseph T. Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, Francesca Pentimalli, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Paolo Pinton, Giovanni Porta, Jochen H. M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Krishnaraj Rajalingam, Kodi S. Ravichandran, Markus Rehm, Jean-Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M. P. Rodrigues, Barak Rotblat, Carla Rothlin, David C. Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M. Ryan, Kristopher A. Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S. Sica, John Silke, Hans-Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R. Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W. G. Tait, Daolin Tang, Nektarios Tavernarakis, Carol M. Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G. Vander Heiden, Jacqueline L. Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K. Voss, Karen H. Vousden, Domagoj Vucic, Daniela Vuri, Erwin F. Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang-Tian Yang, Zahra Zakeri, Joanna E. Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi
Summary: Apoptosis is a regulated cell death process involving caspase family proteases. Inhibiting or delaying apoptosis experimentally through pharmacological and genetic strategies has demonstrated its importance in embryonic development, tissue homeostasis, and the pathogenesis of various human disorders. Defects in apoptotic cell death machinery impair development and promote oncogenesis, while inappropriate activation of apoptosis contributes to cell loss and tissue damage in neurological, cardiovascular, renal, hepatic, infectious, neoplastic, and inflammatory conditions.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Chemistry, Medicinal
Nian-Dong Mao, Yuan Gao, Xia-Wen Dang, Ji-Long Duan, Zi Hui, Hao Che, Yueying Xu, Hang Zhang, Xingrui He, Carmen Garrido, Xiang-Yang Ye
Summary: The study focuses on the design and synthesis of novel HDAC inhibitors based on pyrrolo[2,3-d]pyrimidine and pyrrolo[2,3-b]pyridine scaffolds. Compound B3 showed potent inhibitory activity against multiple HDACs and exhibited significant antiproliferative effects on three tumor cell lines. Mechanistic studies revealed that B3 induces cell cycle arrest and apoptosis in WSU-DLCL-2 cells. These findings suggest further investigation of the compound series for hematological malignancy treatment.
Article
Cell Biology
Flavie Gautheron, Aleksandra Georgievski, Carmen Garrido, Ronan Quere
Summary: Extracellular vesicles (EVs) released by cells in the bone marrow (BM) play an important role in regulating hematopoietic stem cells (HSC) through the transport of bioactive phosphorylated Smad2 (p-Smad2). We found that the EV inhibitor Calpeptin significantly affected the production of p-Smad2-carrying EVs in mouse BM, leading to alterations in HSC quiescence and maintenance. Our study also revealed that p-Smad2 is necessary for the ex vivo maintenance of HSC, as EVs lacking p-Smad2 failed to support HSC survival.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Bogdan B. Grigorash, Dominic van Essen, Guixian Liang, Laurent Grosse, Alexander Emelyanov, Zhixin Kang, Alexey Korablev, Benoit Kanzler, Clement Molina, Elsa Lopez, Oleg N. Demidov, Carmen Garrido, Feng Liu, Simona Saccani, Dmitry V. Bulavin
Summary: Depletion of senescent cells can promote the reprogramming of somatic cells into totipotent-like stem cells and have positive effects on tissue rejuvenation.
NATURE CELL BIOLOGY
(2023)
Correction
Multidisciplinary Sciences
Aurelie de Thonel, Johanna K. Ahlskog, Kevin Daupin, Veronique Dubreuil, Jeremy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluis Cordon Barris, Isabelle Leray, Anna L. Aalto, Sarah Naceri, Marine Cordonnier, Carene Benasolo, Matthieu Sanial, Agathe Duchateau, Anniina Vihervaara, Mikael C. Puustinen, Federico Miozzo, Patricia Fergelot, Elise Lebigot, Alain Verloes, Pierre Gressens, Didier Lacombe, Jessica Gobbo, Carmen Garrido, Sandy D. Westerheide, Laurent David, Michel Petitjean, Olivier Taboureau, Fernando Rodrigues-Lima, Sandrine Passemard, Delara Saberan-Djoneidi, Laurent Nguyen, Madeline Lancaster, Lea Sistonen, Valerie Mezger
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Ying-Hui Yuan, Nian-Dong Mao, Ji-Long Duan, Hang Zhang, Carmen Garrido, Frederic Lirussi, Yuan Gao, Tian Xie, Xiang-Yang Ye
Summary: This article discusses AAK1 inhibitors from the perspectives of structure-based rational molecular design, pharmacology, toxicology, and synthetic routes, aiming to provide up-to-date information and accelerate drug discovery programs in the field of AAK1 small molecule inhibitors.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)