Structural insights into the recognition of histone H3Q5 serotonylation by WDR5

Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout

(2021) Shuai Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3

(2019) Lorna A. Farrelly et al.   NATURE

Histone lactylation links metabolism and gene regulation

(2019) Luke T. Izzo et al.   NATURE

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

(2019) Lance R. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage

(2018) Beth K. Neilsen et al.   BMC CANCER

Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes

(2018) Simon Poepsel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes

(2018) Simon Poepsel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overexpression of glutathione peroxidase 1 predicts poor prognosis in oral squamous cell carcinoma

(2017) Jae Ryung Lee et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Up-regulated WDR5 promotes gastric cancer formation by induced cyclin D1 expression

(2017) Wei Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells

(2017) C Lin et al.   ONCOGENE

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain

(2016) Yuanyuan Li et al.   MOLECULAR CELL

A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression

(2016) H Chen et al.   ONCOGENE

A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks

(2016) Dinshaw J. Patel   Cold Spring Harbor Perspectives in Biology

Neuroblastoma: Molecular Pathogenesis and Therapy

(2015) Chrystal U. Louis et al.   Annual Review of Medicine

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma

(2015) Y. Sun et al.   CANCER RESEARCH

Functional coupling between writers, erasers and readers of histone and DNA methylation

(2015) Idelisse Ortiz Torres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation

(2015) Xu Chen et al.   Scientific Reports

Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1

(2014) X. Su et al.   GENES & DEVELOPMENT

Insight into the Architecture of the NuRD Complex

(2014) Saad S. M. Alqarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

(2013) Shannon M. Lauberth et al.   CELL

Structure of human Rack1 protein at a resolution of 2.45 Å

(2012) David Ruiz Carrillo et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Crystal structure of the human PRMT5:MEP50 complex

(2012) S. Antonysamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network

(2011) Yen-Sin Ang et al.   CELL

Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes

(2011) Weixiang Wang et al.   EMBO REPORTS

MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas

(2011) Ruimin Huang et al.   FASEB JOURNAL

X-Linked Mental Retardation Gene CUL4B Targets Ubiquitylation of H3K4 Methyltransferase Component WDR5 and Regulates Neuronal Gene Expression

(2011) Tadashi Nakagawa et al.   MOLECULAR CELL

Serotonin—more than a neurotransmitter: transglutaminase-mediated serotonylation of C6 glioma cells and fibronectin

(2010) René Hummerich et al.   NEUROCHEMISTRY INTERNATIONAL

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Transglutaminase-Catalyzed Transamidation: A Novel Mechanism for Rac1 Activation by 5-Hydroxytryptamine2A Receptor Stimulation

(2008) Y. Dai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

(2008) Natalia V. Murzina et al.   STRUCTURE

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY