Article
Cell Biology
Xiao-Kun Wang, Ya-Wei Zhang, Chun-Ming Wang, Bo Li, Tian-Zhi Zhang, Wen-Jie Zhou, Lyu-jia Cheng, Ming-Yu Huo, Chang-Hua Zhang, Yu-Long He
Summary: The study showed that METTL16 was highly expressed in gastric cancer and associated with prognosis. In vitro and in vivo experiments confirmed that METTL16 promoted proliferation of GC cells and tumor growth. Furthermore, METTL16 was found to enhance proliferation of GC cells by regulating the expression of cyclin D1.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Li-Li Quan, Jin-Yang Liu, Li-Xia Qu, Hui La, Hai-Li Wang, Xiao-Xia Chen, Na Wang, Zhen-Zhi Wei
Summary: This study analyzed the expression of Cyclin D1 (CCND1) gene in ovarian cancer using the Oncomine database, finding that its high expression is associated with poor prognosis. Cell experiments showed that silencing CCND1 gene expression can reduce ovarian cancer cell proliferation and promote apoptosis.
Article
Cell Biology
Zhe Zhang, Chun Yang, Zixu Wang, Liwei Guo, Yongpan Xu, Ce Gao, Yonghua Sun, Zhenhai Zhang, Jinrong Peng, Minjie Hu, Li Jan Lo, Zhipeng Ma, Jun Chen
Summary: Food digestion requires coordinated cooperation of different digestive organs. In this study, we demonstrated that Wdr5-mediated H3K4 tri-methylation plays a critical role in regulating cell differentiation, proliferation, and apoptosis during zebrafish organogenesis of three major digestive organs. Our findings provide insights into the common molecular mechanisms of cell fate determination in different digestive organs and shed light on the mechanistic basis of human diseases in these organs.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Valerio Nardone, Marcella Barbarino, Antonio Angrisani, Pierpaolo Correale, Pierpaolo Pastina, Salvatore Cappabianca, Alfonso Reginelli, Luciano Mutti, Clelia Miracco, Rocco Giannicola, Antonio Giordano, Luigi Pirtoli
Summary: The expanding clinical application of CDK4- and CDK6-inhibiting drugs in breast cancer has sparked interest in testing them in other tumors. Potential combinations with other therapeutic approaches are being explored, with some hypotheses about integrating CDK4 and CDK6 inhibitors with radiotherapy. However, more research is needed to further investigate the potential benefits of these combinations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Tianci Han, Liang Zhang, Wei Tong, Jian Zhao, Wei Wang
Summary: This study explores the interaction between cyclin D1 and calycosin and provides insights into their binding properties and potential structural changes. The results indicate that hydrogen bonding and van der Waals forces are involved in the binding of calycosin with cyclin D1, leading to structural alterations in cyclin D1. Additionally, calycosin inhibits lung cancer cell proliferation by arresting the cell cycle at the G1 phase.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Saroor A. Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K. Richardson, Jianfeng Ge, Saiful E. Syafruddin, Alyson Speed, Evangelia K. Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dora Bihary, Cissy Yong, David J. Harrison, Grant D. Stewart, Mitchell J. Machiela, Mark P. Purdue, Stephen J. Chanock, Anne Y. Warren, Shamith A. Samarajiwa, Jason S. Carroll, Sakari Vanharanta
Summary: Using experimental models and analysis of patient samples, researchers have demonstrated that the transcription factor PAX8 is essential for oncogenic signaling and plays a key role in two common genetic alterations associated with ccRCC.
Article
Microbiology
Shan Wei, Songjian Lu, Lifan Liang, Xian Wang, Wan Li, Tingting Li, Luping Chen, Enguo Ju, Xinquan Zhang, Zhao Lai, Yufei Huang, Xinghua Lu, Shou-Jiang Gao
Summary: A CRISPR-Cas9 screening revealed the importance of epigenetic regulators in KSHV-induced cellular transformation. GRWD1 interacts with WDR5 and MLL2 to regulate H3K4me3 active mark, affecting gene expression and cellular functions in KSHV-transformed cells. The hijacking of the GRWD1-WDR5-MLL2 complex by KSHV suggests a potential therapeutic target for KSHV-induced cancers.
Article
Biotechnology & Applied Microbiology
Abdul K. Siraj, Sandeep Kumar Parvathareddy, Padmanaban Annaiyappanaidu, Saeeda O. Ahmed, Nabil Siraji, Asma Tulbah, Fouad Al-Dayel, Dahish Ajarim, Khawla S. Al-Kuraya
Summary: The study demonstrated that cyclin D1 over-expression in Middle Eastern breast cancers is associated with favorable prognostic features, serving as an independent predictor of overall survival and recurrence-free survival. Cyclin D1 expression was also found to be associated with phospho-Rb in luminal subtype of breast cancer, predicting luminal A breast cancer independently.
ONCOTARGETS AND THERAPY
(2021)
Article
Cell Biology
Yan Lu, Yijia Shao, Yinping Xie, Huinan Qu, Da Qi, Yuan Dong, Qiu Jin, Liping Wang, Junyuan Wei, Chengshi Quan
Summary: Overexpression of CLAUDIN6 can inhibit the malignant behavior of breast cancer by suppressing cell proliferation, migration, and invasion. CLAUDIN6 achieves this effect by inhibiting the ERK/Sp1/cyclin D1 and ERK/IL-8 signaling pathways.
CELLULAR SIGNALLING
(2022)
Article
Pharmacology & Pharmacy
Ankur Sharma, Xin Liu, Vishal Chandra, Rajani Rai, Doris M. Benbrook, Sukyung Woo
Summary: The study investigated the pharmacodynamic effects of SHetA2 in ovarian cancer models and established a physiologically based pharmacokinetic/pharmacodynamic model. The results showed that oral administration of 60 mg/kg of SHetA2 for 7 days achieved consistent plasma pharmacokinetics and tissue distribution, effectively inhibiting the growth of ovarian cancer cell lines. Cyclin D1 was identified as a potential pharmacodynamic marker for SHetA2.
Article
Oncology
Zhengyan Yang, Hongyun Xu, Yupo Yang, Chaoqun Duan, Pai Zhang, Yang Wang, Kai Fu, Yonghong Shen, Marvin Xuejun Xu
Summary: In this study, a new naphthalene derivative called SMY002 was synthesized, which showed potent inhibitory effects on the STAT3 signal in TNBC cells. SMY002 directly interacted with the SH2 domain of STAT3, leading to inhibition of phosphorylation, dimerization, nuclear distribution, transcriptional activity, and target genes expression of STAT3. SMY002 also suppressed migration, invasion, survival, growth, and metastasis of TNBC cells in vitro and in vivo by down-regulating the expression of Cyclin D1 and MMP9.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Biochemistry & Molecular Biology
Dongyang Liu, Ke Shi, Mingshi Fu, Feng Chen
Summary: PLAC1 is a highly expressed cancer-testis antigen in gastric cancer, promoting gastric cancer cell proliferation through the AKT/GSK-3β/cyclin D1 signaling pathway and associated with poor prognosis. The study suggests that PLAC1 might be a useful molecular marker for gastric cancer diagnosis, prognosis, and treatment.
Article
Biochemistry & Molecular Biology
Guoquan Huang, Zhenxian Xiang, Haitao Wu, Qiuming He, Rongzhang Dou, Zaihuan Lin, Chaogang Yang, Sihao Huang, Jialin Song, Ziyang Di, Shuyi Wang, Bin Xiong
Summary: This study found that BDNF-AS is highly expressed in gastric cancer and peritoneal metastasis tissues, and its overexpression is associated with gastric cancer progression and poor prognosis. BDNF-AS overexpression protects gastric cancer cells from ferroptosis and promotes the progression of gastric cancer and peritoneal metastasis. Mechanistically, BDNF-AS regulates the transcription of FBXW7 by recruiting WDR5, thus affecting the ubiquitination of VDAC3.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ying Hou, Rong Liu, Mengwei Xia, Chong Sun, Bingling Zhong, Jie Yu, Nana Ai, Jin-Jian Lu, Wei Ge, Bo Liu, Xiuping Chen
Summary: NAN triggers G1 phase cell cycle arrest and caspase-independent apoptosis in CRC cells through downregulation of cyclin D1 and inhibition of eEF1A-targeted translation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Emily Kwun Kwan Lo, Jetty Chung-Yung Lee, Paul C. Turner, Hani El-Nezami
Summary: ZEA has a growth-promoting effect on colon cancer cells, potentially mediated through the GPER signaling pathway. This study provides a new perspective on the carcinogenicity of ZEA.
SCIENTIFIC REPORTS
(2021)