Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases

Role of p38 mitogen‐activated protein kinase signalling in virus replication and potential for developing broad spectrum antiviral drugs

(2021) Yogesh Chander et al.   REVIEWS IN MEDICAL VIROLOGY

p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response

(2021) Shun Kageyama et al.   Nature Communications

Betulinic Acid Alleviates Spleen Oxidative Damage Induced by Acute Intraperitoneal Exposure to T-2 Toxin by Activating Nrf2 and Inhibiting MAPK Signaling Pathways

(2021) Li Kong et al.   Antioxidants

Treatment of Oxidative Stress with Exosomes in Myocardial Ischemia

(2021) Yun Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adding high-sensitivity C-reactive protein to frailty assessment to predict mortality and cardiovascular events in elderly inpatients with cardiovascular disease

(2021) Si-Min Yao et al.   EXPERIMENTAL GERONTOLOGY

Granulocyte colony-stimulating factor attenuates myocardial remodeling and ventricular arrhythmia susceptibility via the JAK2-STAT3 pathway in a rabbit model of coronary microembolization

(2020) Weiwei Wang et al.   BMC Cardiovascular Disorders

The important role of histone deacetylases in modulating vascular physiology and arteriosclerosis

(2020) Ting C. Zhao et al.   ATHEROSCLEROSIS

Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway

(2020) ChangHyuk Kwon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HNGF6A Inhibits Oxidative Stress-Induced MC3T3-E1 Cell Apoptosis and Osteoblast Phenotype Inhibition by Targeting Circ_0001843/miR-214 Pathway

(2020) Xiao Zhu et al.   CALCIFIED TISSUE INTERNATIONAL

Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD

(2020) Jinfeng Zhao et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Keap1 governs ageing-induced protein aggregation in endothelial cells

(2020) Aleksandra Kopacz et al.   Redox Biology

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

(2020) Kelvin Yen et al.   Aging-US

[Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs

(2020) Yu Ding et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Epac1 (Exchange Protein Directly Activated by cAMP 1) Upregulates LOX-1 (Oxidized Low-Density Lipoprotein Receptor 1) to Promote Foam Cell Formation and Atherosclerosis Development

(2020) William G. Robichaux et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fucoidan from Fucus vesiculosus attenuates doxorubicin-induced acute cardiotoxicity by regulating JAK2/STAT3-mediated apoptosis and autophagy

(2020) Jie Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome

(2020) Wenfeng Li et al.   ACS Omega

Agaricus blazei polypeptide exerts a protective effect on D‐galactose‐induced aging mice via the Keap1/Nrf2/ARE and P53/Trim32 signaling pathways

(2020) Qingxia Feng et al.   JOURNAL OF FOOD BIOCHEMISTRY

Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway

(2020) Yingying Wang et al.   MOLECULAR HUMAN REPRODUCTION

Oxidative Stress and Antioxidant Treatments in Cardiovascular Diseases

(2020) Wenjun Wang et al.   Antioxidants

FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

(2019) Zhi Geng et al.   Journal of Translational Medicine

Gas6 attenuates lipopolysaccharide‑induced TNF‑α�expression and apoptosis in H9C2 cells through NF‑κB and�MAPK inhibition via the Axl/PI3K/Akt pathway

(2019) Mengfang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation

(2019) Patricia Marchio et al.   Oxidative Medicine and Cellular Longevity

Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production

(2019) Ran Wei et al.   Scientific Reports

[Gly14]‐Humanin Prevents Lipid Deposition and Endothelial Cell Apoptosis in a Lectin‐like Oxidized Low‐density Lipoprotein Receptor‐1‐Dependent Manner

(2019) Yu Ding et al.   LIPIDS

Chronic Treatment With the Mitochondrial Peptide Humanin Prevents Age-related Myocardial Fibrosis in mice

(2018) Qing Qin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells

(2018) Qingqing Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibroblast growth factor 19 protects the heart from oxidative stress-induced diabetic cardiomyopathy via activation of AMPK/Nrf2/HO-1 pathway

(2018) Xin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of autophagy factors by oxidative stress and cardiac enzymes imbalance during arsenic or/and copper induced cardiotoxicity in Gallus gallus

(2018) Siwen Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Humanin Exerts Neuroprotection During Cardiac Ischemia-Reperfusion Injury

(2018) Sirinart Kumfu et al.   JOURNAL OF ALZHEIMERS DISEASE

Humanin directly protects cardiac mitochondria against dysfunction initiated by oxidative stress by decreasing complex I activity

(2018) Savitree Thummasorn et al.   MITOCHONDRION

Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2

(2018) Xiaohui Wang et al.   MOLECULAR IMMUNOLOGY

Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart

(2018) Hong Yang et al.   Cell Death & Disease

Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin

(2018) Natividad Blasco et al.   Redox Biology

Autophagy in Cardiovascular Aging

(2018) Mahmoud Abdellatif et al.   CIRCULATION RESEARCH

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mitochondrial Encoded Messenger at the Nucleus

(2018) Cheryl Yong et al.   Cells

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Gregory A Roth et al.   LANCET

Humanin is an endogenous activator of chaperone-mediated autophagy

(2017) Zhenwei Gong et al.   JOURNAL OF CELL BIOLOGY

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

S14G-humanin alleviates insulin resistance and increases autophagy in neurons of APP/PS1 transgenic mouse

(2017) Kun Han et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cardioprotective effects of ulinastatin against isoproterenol-induced chronic heart failure through the PI3K‑Akt, p38 MAPK and NF-κB pathways

(2017) Lin Li et al.   Molecular Medicine Reports

Humanin analogue, S14G-humanin, has neuroprotective effects against oxygen glucose deprivation/reoxygenation by reactivating Jak2/Stat3 signaling through the PI3K/AKT pathway

(2017) Guang-Sheng Gao et al.   Experimental and Therapeutic Medicine

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases?

(2016) Alejandro Silva-Palacios et al.   AGEING RESEARCH REVIEWS

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers

(2016) Laura J. Cobb et al.   Aging-US

Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway

(2016) Jing Liu et al.   APOPTOSIS

Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation

(2016) Wei Ming et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Humanin exerts cardioprotection against cardiac ischemia/reperfusion injury through attenuation of mitochondrial dysfunction

(2016) Savitree Thummasorn et al.   Cardiovascular Therapeutics

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Humanin: Functional Interfaces with IGF-I

(2016) J. Xiao et al.   GROWTH HORMONE & IGF RESEARCH

The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus

(2016) Su-Jeong Kim et al.   Oncotarget

Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes

(2016) Lina Li et al.   Cell and Bioscience

Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging

(2015) Jaime L. Schneider et al.   AGING CELL

H2S restores the cardioprotection from ischemic post-conditioning in isolated aged rat hearts

(2015) Can Wei et al.   CELL BIOLOGY INTERNATIONAL

Isoliquiritigenin Inhibits Interferon-γ-Inducible Genes Expression in Hepatocytes through Down-Regulating Activation of JAK1/STAT1, IRF3/MyD88, ERK/MAPK, JNK/MAPK and PI3K/Akt Signaling Pathways

(2015) Shanshan Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

IGF-I regulates the age-dependent signaling peptide humanin

(2014) Changhan Lee et al.   AGING CELL

Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells

(2014) Ying Xie et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Increased Age-Related Cardiac Dysfunction in Bradykinin B2 Receptor–Deficient Mice

(2014) Wenjing Feng et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties

(2014) Barbara Zapała et al.   Pharmacological Reports

Humanin and Age-Related Diseases: A New Link?

(2014) Zhenwei Gong et al.   Frontiers in Endocrinology

A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts

(2013) Laura E. Klein et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell

(2013) Regina Kuliawat et al.   FASEB JOURNAL

SH3-binding Protein 5 Mediates the Neuroprotective Effect of the Secreted Bioactive Peptide Humanin by Inhibiting c-Jun NH2-terminal Kinase

(2013) Yuji Takeshita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Humanin: a harbinger of mitochondrial-derived peptides?

(2013) Changhan Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Toward clinical application of the Keap1–Nrf2 pathway

(2013) Takafumi Suzuki et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis

(2013) Y. Jia et al.   Andrology

Circulating humanin levels are associated with preserved coronary endothelial function

(2012) R. J. Widmer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The emerging role of the mitochondrial-derived peptide humanin in stress resistance

(2012) Kelvin Yen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Neuroprotective Peptide Humanin Inhibits Inflammatory Response in Astrocytes Induced by Lipopolysaccharide

(2012) Shen-Ting Zhao et al.   NEUROCHEMICAL RESEARCH

NR2A and NR2B subunits differentially mediate MAP kinase signaling and mitochondrial morphology following excitotoxic insult

(2012) Anthony M. Choo et al.   NEUROCHEMISTRY INTERNATIONAL

Humanin, a Cytoprotective Peptide, Is Expressed in Carotid Artherosclerotic Plaques in Humans

(2012) David G. Zacharias et al.   PLoS One

Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice

(2011) Yun K. Oh et al.   ATHEROSCLEROSIS

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Chaperone-mediated autophagy at a glance

(2011) S. Kaushik et al.   JOURNAL OF CELL SCIENCE

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Humanin Protects Cortical Neurons from Ischemia and Reperfusion Injury by the Increased Activity of Superoxide Dismutase

(2011) Shen-Ting Zhao et al.   NEUROCHEMICAL RESEARCH

Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice

(2010) Radhika H. Muzumdar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress

(2010) A. R. Bachar et al.   CARDIOVASCULAR RESEARCH

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

Mediation of Electronegative Low-Density Lipoprotein Signaling by LOX-1

(2009) Jonathan Lu et al.   CIRCULATION RESEARCH

Evidence for potential functionality of nuclearly-encoded humanin isoforms

(2009) Marek Bodzioch et al.   GENOMICS

The neurosurvival factor Humanin inhibits β-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice

(2009) Phuong T. Hoang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Humanin Inhibits Neuronal Cell Death by Interacting with a Cytokine Receptor Complex or Complexes Involving CNTF Receptor α/WSX-1/gp130

(2009) Yuichi Hashimoto et al.   MOLECULAR BIOLOGY OF THE CELL

Humanin and the Receptors for Humanin

(2009) Masaaki Matsuoka et al.   MOLECULAR NEUROBIOLOGY

Humanin: A Novel Central Regulator of Peripheral Insulin Action

(2009) Radhika H. Muzumdar et al.   PLoS One

JAK/STAT and PI3K/AKT Pathways Form a Mutual Transactivation Loop and Afford Resistance to Oxidative Stress-Induced Apoptosis in Cardiomyocytes

(2008) Yanjie Lu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE