Article
Plant Sciences
Gang Shu, Dan Xu, Wei Zhang, Xiaoling Zhao, Haohuan Li, Funeng Xu, Lizi Yin, Xi Peng, Hualin Fu, Li-Jen Chang, Xiao-Rong Yan, Juchun Lin
Summary: This study developed a novel SH-liposome with improved anti-MRSA effect and demonstrated its beneficial wound healing effects. The SH-liposome showed sustained-release behavior, improved antibacterial ability, and promoted effective healing of infected burn wounds.
Article
Microbiology
Xiaolin Feng, Kexin Feng, Qinhua Zheng, Weijian Tan, Wenting Zhong, Caiyu Liao, Yuntong Liu, Shangjian Li, Wenzhong Hu
Summary: Geraniol nanoemulsions prepared based on Tween 80 and medium chain triglyceride showed good stability and antibacterial activity. The nanoemulsion had a small particle size and high encapsulation efficiency, and exhibited significant inhibition effect against foodborne pathogenic bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nermeen B. B. Ali, Riham A. A. El-Shiekh, Rehab M. M. Ashour, Sabah H. H. El-Gayed, Essam Abdel-Sattar, Mariam Hassan
Summary: Red onion wastes (ROW) contain bioactive metabolites with potent antimicrobial effects, which were tested against MRSA bacteria in this study. The acidified ethanolic extract of red onion scales (RO-T), as well as its anthocyanin-rich fraction (RO-P) and flavonoid-rich fraction (RO-S), showed promising antibacterial activity. RO-S had the highest activity against MRSA and could eradicate biofilm formation. In vivo assessment using a rat model confirmed the significant reduction of MRSA bacterial load by the RO-T extract and vancomycin.
Article
Chemistry, Medicinal
Xiao Wang, Hongda Qiu, Na Yang, Haoji Xie, Weida Liang, Jiayu Lin, Haifeng Zhu, Yuan Zhou, Ning Wang, Xinyi Tan, Jiale Zhou, Wei Cui, Da Teng, Jianhua Wang, Hongze Liang
Summary: In this study, a series of fascaplysin derivatives and their beta-carboline precursors were synthesized and investigated for their antibacterial/antibiofilm activity and mechanisms against MRSA. The results showed that fascaplysins exhibited superior antimicrobial activity, with compound 18 being the most potent and least toxic. Mechanisms exploration revealed that compound 18 has strong ability to destroy bacterial cell wall and membrane and high binding affinity to bacterial genomic DNA. Molecular docking study suggested the important role of cationic five-ring coplanar backbone and the introduction of N-aryl amide at 9-position in promoting the combination of compound 18 and DNA.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuanyuan Hu, Hao Zhou, Jinxu Huang, Guangxing Pan, Hao Wang, Tiansheng Wang, Congwei Yu, Ling Zhang, Deming Gou, Jiaheng Zhang
Summary: The development of new structural agents with significant antimicrobial potential is necessary due to the increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to antibiotics. A novel class of 2-hydroxypropyl group linked derivatives of indole azoles was found to have excellent antibacterial capacity against MRSA. Compound 4a showed low toxicity and did not cause drug-resistance in MRSA after multiple generations. Its mechanism of action involves infiltration of the MRSA membrane and insertion into MRSA DNA to prevent replication, resulting in strong inhibition of the bacteria. The highly active derivative 4a also responded well to inflammatory factors and had the potential to be a multifunctional anti-MRSA agent.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Microbiology
Kexin Gu, Ping Ouyang, Yuxin Hong, Yuyun Dai, Ting Tang, Changliang He, Gang Shu, Xiaoxia Liang, Huaqiao Tang, Ling Zhu, Zhiwen Xu, Lizi Yin
Summary: The study evaluated the efficacy of geraniol as a treatment for MRSA biofilm infection and found that it effectively inhibited biofilm formation and removal, influenced the biofilm structure of MRSA, and inhibited major virulence factors. This suggests the potential of geraniol as an anti-MRSA biofilm drug and a solution for clinical treatment of biofilm infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mauricio Osorio, Marcela Carvajal, Alejandra Vergara, Estefania Butassi, Susana Zacchino, Carolina Mascayano, Margarita Montoya, Sophia Mejias, Marcelo Cortez-San Martin, Yesseny Vasquez-Martinez
Summary: Prenylated flavonoids are important natural compounds with significant biological activity, particularly in antimicrobial functions. Compounds 11, 12, and 13 showed strong inhibitory activity against human pathogenic fungi and clinical isolated Staphylococcus aureus MRSA, indicating the key structural requirements for antibacterial activity. Additionally, the combination of prenylated flavonoids with commercial antibiotics significantly enhanced the antibacterial activity against drug-resistant bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yangyi Qiu, Adrian Jun Chu, Tsz Fung Tsang, Yingbo Zheng, Nga Man Lam, Kendra Sek Lam Li, Margaret Ip, Xiao Yang, Cong Ma
Summary: A series of new derivative inhibitors with good antimicrobial activity against clinically significant pathogens were discovered in this study. Compound 22r exhibited the best antimicrobial activity with the lowest inhibitory concentration against diverse bacteria.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Bo Li, Zhe Zhang, Jian-Feng Zhang, Jie Liu, Xiang-Yi Zuo, Fang Chen, Guang-Yu Zhang, Han-Qing Fang, Zhen Jin, You-Zhi Tang
Summary: A series of pleuromutilin derivatives with 1,2,4-triazole-3-substituted Schiff base structure were designed and synthesized, among which one compound exhibited superior in vitro antibacterial effect against MRSA with low resistance development. This compound also showed faster bactericidal kinetic, longer PAE time, and no significant inhibitory effect on normal cells, indicating its potential as a promising antibacterial agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Bettina Quintanilha Magalhaes, Francisco P. Machado, Paola S. Sanches, Barbara Lima, Deborah Quintanilha Falcao, Natalia von Ranke, Murilo Lamim Bello, Carlos Rangel Rodrigues, Marcelo Guerra Santos, Leandro Rocha, Robson X. Faria
Summary: The study found that Eugenia sulcata essential oil and its nanoemulsion have inhibitory effects on P2X7R activity and can reverse inflammatory response. The main substance, beta-caryophyllene, showed a high inhibitory effect but may have toxic effects on humans. This research provides insights for the development of new anti-inflammatory therapies.
Article
Biochemistry & Molecular Biology
Yunxing Fu, Chunqing Leng, Yuan Fan, Xia Ma, Xianghui Li, Xuefei Wang, Zhenghuan Guo, Xiujun Wang, Ruofeng Shang
Summary: DPTM, a new pleuromutilin derivative, showed potent antibacterial activity against MRSA and promoted wound healing in a murine skin infection model. It also decreased the secretion of inflammatory cytokines IL-6 and TNF-alpha in plasma. These results highlight the potential of DPTM as a novel antibacterial agent.
Article
Biochemistry & Molecular Biology
Rafael Cardoso Maciel Costa Silva, Luis Tan, Danielle Aparecida Rodrigues, Elisa Beatriz Prestes, Caroline Pereira Gomes, Andreza Moreira Gama, Pedro Lagerblad de Oliveira, Claudia Neto Paiva, Benedicte Manoury, Marcelo Torres Bozza
Summary: The study indicates that chloroquine may be used as a supportive therapy to control heme-induced deleterious inflammation in different hemolytic diseases by inhibiting inflammatory effects induced by heme.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Chemistry, Medicinal
Tingting Meng, Yani Hou, Congshan Shang, Jing Zhang, Bo Zhang
Summary: Indole derivatives are important antibacterial agents that can act against MRSA and other bacteria; through strategies such as dimerization and hybridization, new potential anti-MRSA agents with antibacterial activity have been discovered.
ARCHIV DER PHARMAZIE
(2021)
Article
Biochemistry & Molecular Biology
Mayara A. R. Garcia, Reinaldo S. Theodoro, Janaina C. O. Sardi, Mariana B. Santos, Gabriela M. Ayusso, Fernando R. Pavan, Alan R. Costa, Lucas M. Santa Cruz, Pedro L. Rosalen, Luis O. Regasini
Summary: The designed and synthesized 4-bromo-3'-aminochalcone (5f) demonstrated potent antibacterial activity against methicillin-susceptible and methicillin-resistant Staphylococcus aureus, with potential for biofilm reduction and new applications as an antibacterial agent.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Huijuan Li, Xinghui Song, Huiru Li, Lifei Zhu, Shengbo Cao, Jifeng Liu
Summary: Two undescribed ether derivatives of sesquiterpenes and one new monoterpene glycoside were isolated from the stems and leaves of I. simonsii. They exhibited antibacterial activity, with compounds 6 and 7 showing good activity against S. aureus and MRSA, and resistance development was not observed.