Review
Biochemistry & Molecular Biology
Fabio Valenti, Italia Falcone, Sara Ungania, Flora Desiderio, Patrizio Giacomini, Chiara Bazzichetto, Fabiana Conciatori, Enzo Gallo, Francesco Cognetti, Gennaro Ciliberto, Aldo Morrone, Antonino Guerrisi
Summary: Treatment and management of metastatic melanoma have evolved significantly in the era of personalized medicine, benefiting from immunotherapy and advancements in multi-omics analyses. While improving clinical management, precision medicine plays a crucial role in guiding treatment decisions for individual patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Elettra Barberis, Shahzaib Khoso, Antonio Sica, Marco Falasca, Alessandra Gennari, Francesco Dondero, Antreas Afantitis, Marcello Manfredi
Summary: This review discusses the application of recent technological innovations in mass spectrometry to metabolomics analysis, with a focus on the use of artificial intelligence (AI) strategies. The article also explores the challenges and limitations of implementing metabolomics-AI systems, as well as recent tools and studies in disease classification and biomarker identification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Matthias Pierce, Richard Emsley
Summary: The regression approach performs better than Kraemer's approach in various data-generating scenarios. The modification of Kraemer's approach shows improved treatment recommendations, unless there is a strong unobserved prognostic biomarker. In the FINE trial, the regression method demonstrates slight improvement under its personalized treatment recommendation algorithm.
Review
Medicine, General & Internal
Hassan Mumtaz, Muhammad Saqib, Sidra Jabeen, Muhammad Muneeb, Wajiha Mughal, Hassan Sohail, Myra Safdar, Qasim Mehmood, Muhammad Ahsan Khan, Syed Muhammad Ismail
Summary: The core idea of precision medicine is to use biomarkers to identify subpopulations with different disease risks, drug responsiveness, and treatment outcomes. Artificial intelligence (AI) plays a crucial role in precision medicine by analyzing multidimensional clinical and biological data, aiding in precise diagnoses, accelerating drug discovery, and optimizing treatment outcomes.
FRONTIERS IN MEDICINE
(2023)
Review
Oncology
R. Casolino, C. Braconi, G. Malleo, S. Paiella, C. Bassi, M. Milella, S. B. Dreyer, F. E. M. Froeling, D. K. Chang, A. Biankin, T. Golan
Summary: This review emphasizes the importance of personalized therapeutic approaches based on genomic factors in the preoperative setting for pancreatic cancer to reduce mortality rates.
ANNALS OF ONCOLOGY
(2021)
Article
Neurosciences
Brianna Gurdon, Catherine Kaczorowski
Summary: Alzheimer's disease is a complex disease mediated by numerous factors, with research focusing on how imaging modalities can be integrated into systems biology approaches to understand the genotype to phenotype relationship driving disease development. By combining imaging and omics data, AD can be classified into subtypes, paving the way for precision medicine solutions to prevent and treat the disease.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Psychology, Clinical
Dale L. Smith, Philip Held
Summary: In this study, researchers explored the use of machine learning methods to predict the endpoint severity of posttraumatic stress disorder (PTSD) treatment. They found that these models had high predictive accuracy at different time points during the treatment process.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Mark Gray, Jamie R. K. Marland, Alan F. Murray, David J. Argyle, Mark A. Potter
Summary: Development of an anastomotic leak (AL) following colorectal cancer surgery is a life-threatening complication that can lead to severe consequences such as abdominal contamination and peritonitis. Current research is focusing on identifying diagnostic or predictive biomarkers for AL to enhance post-operative care and improve outcomes for patients. Although no AL biomarker has been validated in large-scale clinical trials yet, personalized medicine through biomarker analysis could hold promise for colorectal cancer patients undergoing intestinal resection and anastomosis in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Leonard Kozarzewski, Lukas Maurer, Anja Maehler, Joachim Spranger, Martin Weygandt
Summary: Obesity is a worldwide disease with treatments including lifestyle interventions, pharmacological treatment, and bariatric surgery. Neuroimaging and computational modeling are used to predict treatment outcomes, emphasizing the importance of incentive salience and psychobehavioral control for obesity treatment success, but further studies with larger sample sizes and validation processes are needed for clinical application.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Medicine, General & Internal
Richard Rosenquist, Elsa Bernard, Tom Erkers, David W. Scott, Raphael Itzykson, Philippe Rousselot, Jean Soulier, Martin Hutchings, Paivi Ostling, Lucia Cavelier, Thoas Fioretos, Karin E. Smedby
Summary: Genetic testing has been used in clinical routine diagnostics of hematological malignancies for years to improve disease classification, prognostication, patient management, and survival. Recent classifications of hematological malignancies define disease subtypes based on key recurrent genetic alterations detected by conventional methods. Through advanced sequencing techniques, broad genomic tests can now be applied to identify clinically important markers. Precision diagnostics have been implemented in myeloid and lymphoid malignancies to guide treatment selection and improve survival. The potential of monitoring measurable residual disease and functional precision medicine is also discussed.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Duaa Ahmed Elhag, Manoj Kumar, Marwa Saadaoui, Anthony K. Akobeng, Fatma Al-Mudahka, Mamoun Elawad, Souhaila Al Khodor
Summary: Inflammatory bowel disease is a chronic immune-mediated inflammation of the gastrointestinal tract with a relapsing and remitting clinical course. Continuous disease monitoring and personalized therapy algorithms are crucial for effective treatment. New therapeutic approaches are being evaluated in controlled clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Theodoros Karampitsakos, Brenda M. Juan-Guardela, Argyris Tzouvelekis, Jose D. Herazo-Maya
Summary: Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and lethal chronic lung disease. Precision medicine approaches have not been effectively implemented in IPF clinical practice, despite the existence of numerous diagnostic, prognostic, and theragnostic biomarker candidates.
Review
Cardiac & Cardiovascular Systems
Clint L. Miller, Amy R. Kontorovich, Ke Hao, Lijiang Ma, Conrad Iyegbe, Johan L. M. Bjorkegren, Jason C. Kovacic
Summary: Atherosclerosis is the most common vascular disease worldwide, while Mendelian vascular diseases are caused by single genetic changes. These two types of diseases have very different genetic bases, thus requiring different precision medicine approaches for treatment.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Critical Care Medicine
Christian Bode, Sebastian Weis, Andrea Sauer, Pedro Wendel-Garcia, Sascha David
Summary: This article explores the immune dysregulation in sepsis and studies on treatment methods targeting the host response, as well as discusses the future prospects of precision medicine approaches in sepsis.
Review
Oncology
Richard C. Wang, Zhixiang Wang
Summary: The concept of precision medicine, based on genomics, emerged after the Human Genome Project. Precision medicine allows tailored treatment for different patient subpopulations based on their susceptibility to specific diseases or responsiveness to specific therapies. This review examines the history, development, and future perspective of precision medicine and discusses its concepts, principles, tools, and applications.