Review
Biochemistry & Molecular Biology
Stuart L. Rulten, Richard P. Grose, Susanne A. Gatz, J. Louise Jones, Angus J. M. Cameron
Summary: Our understanding of cancer has advanced rapidly, recognizing the variation between patients and leading to precision medicines that promise maximum efficacy, safety, and reduced costs. However, many patients still lack access to these personalized treatments, highlighting the need for new disease characteristics, accurate diagnosis, better clinical trials, and global accessibility to targeted therapies. This review discusses current technological trends and multidisciplinary efforts to ensure wider implementation of precision oncology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Dairy & Animal Science
Tharangani R. W. Perera, David A. Skerrett-Byrne, Zamira Gibb, Brett Nixon, Aleona Swegen
Summary: This review outlines the role of new technologies in biomarker discovery, specifically in the veterinary field, with a focus on 'omics' platforms. It discusses the challenges faced in the process of biomarker development and emphasizes the importance of collaboration between clinicians, researchers, and funding bodies. The review also highlights the need for clear goals and adequate resources to ensure successful translation of biomarkers into clinical practice.
Review
Biochemistry & Molecular Biology
Sabba Mehmood, Muhammad Faheem, Hammad Ismail, Syeda Mehpara Farhat, Mahwish Ali, Sidra Younis, Muhammad Nadeem Asghar
Summary: Breast carcinoma is the most prevalent cancer in women worldwide, and although significant progress has been made in its diagnosis and treatment, therapeutic resistance remains a major clinical complication. Integrated data assessments through multiomics can provide valuable insights for therapeutic decisions, and personalized medicine based on genetic and non-genetic tests can enhance treatment outcomes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Allergy
Tomas Clive Barker-Tejeda, Raphaelle Bazire, David Obeso, Leticia Mera-Berriatua, Domenico Rosace, Sonia Vazquez-Cortes, Tania Ramos, Maria del Pilar Rico, Tomas Chivato, Coral Barbas, Alma Villasenor, Maria M. Escribese, Montserrat Fernandez-Rivas, Carlos Blanco, Domingo Barber
Summary: This study investigated the immunological changes in grass-pollen-allergic patients undergoing SLIT treatment, revealing that Mono-sensitized patients showed suppression of effector cells after two years of treatment, while Poly-sensitized patients exhibited higher inflammation levels at baseline.
Review
Nutrition & Dietetics
Omar Ramos-Lopez, J. Alfredo Martinez, Fermin Milagro
Summary: The combination of multiple omics approaches provides a comprehensive view of human diseases and their underlying molecular and physiological events, aiding in the understanding of metabolic phenotypes and disease associations, guiding dietary treatments and prognosis. However, challenges include ethical and regulatory issues, lack of reliable and reproducible results, high cost and high-dimensional data analysis.
Article
Cardiac & Cardiovascular Systems
Keqiang Yan, Zhanlong Mei, Jingjing Zhao, Md Aminul Islam Prodhan, Detlef Obal, Kartik Katragadda, Benjamin Doelling, David Hoetker, Dheeraj Kumar Posa, Liqing He, Xinmin Yin, Jasmit Shah, Jianmin Pan, Shesh Rai, Pawel Konrad Lorkiewicz, Xiang Zhang, Siqi Liu, Aruni Bhatnagar, Shahid P. Baba
Summary: This study reveals the central role of histidyl dipeptides in coordinated regulation of myocardial structure, function, and energetics through integrated triomics approach. Higher levels of histidyl dipeptides in the heart were associated with extensive changes in microRNAs targeting contractile proteins, beta-fatty acid oxidation, and citric acid cycle enzymes. The overexpression of carnosine synthesizing enzyme in mice led to enrichment in the expression of contractile proteins, beta-fatty acid oxidation enzymes, and the TCA in the heart. Integration of multiple data sets suggested that beta-fatty acid oxidation and TCA pathways exhibit correlative changes in the Carns transgenic hearts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Biochemistry & Molecular Biology
Tianyuan Xu, Zhong Zheng, Weili Zhao
Summary: Follicular lymphoma (FL) is a heterogeneous lymphoma originating from germinal center B cells. Multi-omics analysis has revealed abnormalities in FL cells and tumor microenvironment, providing insights into the mechanisms of FL progression and potential therapeutic options.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medical Laboratory Technology
Tianyang Wang, Ping Li, Xiangyu Meng, Jinling Zhang, Qi Liu, Cuicui Jia, Nana Meng, Kunjie Zhu, Dan Lv, Lei Sun, Tinghuizi Shang, Yan Lin, Weipan Niu, Song Lin
Summary: This study used an integrated multi-omic approach to differentiate healthy subjects from schizophrenia patients. By combining metabolomic and transcriptomic platforms, 86 differential metabolites and 189 differential expression genes were identified as potential biomarkers for schizophrenia. The functional relationships between metabolites and genes were further studied, providing more precise information on the mechanism and diagnostic evidence of schizophrenia. The establishment of characteristic diagnostic formulas enhances the predictive ability of the diagnostic spectrums.
CLINICA CHIMICA ACTA
(2022)
Review
Obstetrics & Gynecology
Shikha Rani, Piyush Chandna
Summary: Polycystic ovarian syndrome (PCOS) is a common endocrine, psychological, reproductive, and metabolic disorder that can lead to multiple morbidities. The etiology of PCOS is not fully understood. Biomarkers have potential applications in screening, diagnosis, and monitoring of PCOS.
REPRODUCTIVE SCIENCES
(2023)
Review
Plant Sciences
Federico Scossa, Saleh Alseekh, Alisdair R. Fernie
Summary: Our agricultural systems are facing the urgent challenge of feeding a growing global population, requiring a better understanding of plant genetic and phenotypic diversity. Recent advances in plant genomics, combined with molecular profiling approaches such as genomics, transcriptomics, and metabolomics, offer insights into the complex architecture of agricultural traits and guide crop breeding strategies.
JOURNAL OF PLANT PHYSIOLOGY
(2021)
Review
Oncology
Zijian Zou, Wei Sun, Yu Xu, Wanlin Liu, Jingqin Zhong, Xinyi Lin, Yong Chen
Summary: Sarcomas are rare mesenchymal neoplasms with unique genetic characteristics, and their diagnosis relies heavily on pathological examination. Advanced treatments and multi-omics approaches have shown promise in improving outcomes and understanding sarcomas, but further research is needed to optimize their clinical application.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Alexander Arsov, Kaloyan Petrov, Penka Petrova
Summary: This article discusses the potential of microbial production of butanol as a new fuel and the challenge of butanol toxicity to microbes. Modern omics approaches have made significant progress in addressing the issue of low butanol tolerance, but a strain capable of both synthesis and tolerance at commercializable concentrations has yet to be discovered or produced.
BIOTECHNOLOGY ADVANCES
(2021)
Review
Food Science & Technology
Karolinny Cristiny de Oliveira Vieira, Hevelin Regiane Augusto da Silva, Isabela Poletto Masselli Rocha, Emmanuel Barboza, Lizziane Kretli Winkelstroter Eller
Summary: Outbreaks and deaths related to Foodborne Diseases (FBD) are constantly occurring worldwide, largely due to consumption of contaminated foodstuffs with pathogens. This review discusses the main omic techniques applied in foodborne pathogens and their potential in ensuring food safety. Omics have been shown to integrate variables that contribute to food safety and improve consumer health, costs, and product quality.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Clinical Neurology
Dominique F. Leitner, Yik Siu, Aryeh Korman, Ziyan Lin, Evgeny Kanshin, Daniel Friedman, Sasha Devore, Beatrix Ueberheide, Aristotelis Tsirigos, Drew R. Jones, Thomas Wisniewski, Orrin Devinsky
Summary: High-fat and low-carbohydrate diets, such as the modified Atkins diet (MAD), can reduce seizure frequency in treatment-resistant epilepsy patients. These diets mimic fasting and induce high levels of ketone bodies, potentially shifting brain energy production and impacting neuronal and astrocyte metabolism.
Review
Oncology
Luigi Fattore, Ciro Francesco Ruggiero, Domenico Liguoro, Vittorio Castaldo, Angiolina Catizone, Gennaro Ciliberto, Rita Mancini
Summary: Immunotherapy has revolutionized the treatment of metastatic melanoma by increasing long term overall survival, but the prediction of patient response is still a challenge. Liquid Biopsies (LBs) have emerged as a promising tool to predict response to immunotherapy through non-invasive biomarker measurements, and are expected to become a routine practice in guiding clinical decisions for cancer immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Rossella Loria, Valentina Laquintana, Stefano Scalera, Rocco Fraioli, Valentina Caprara, Italia Falcone, Chiara Bazzichetto, Marta Di Martile, Laura Rosano, Donatella Del Bufalo, Gianluca Bossi, Isabella Sperduti, Irene Terrenato, Paolo Visca, Silvia Soddu, Michele Milella, Gennaro Ciliberto, Rita Falcioni, Virginia Ferraresi, Giulia Bon
Summary: This study reveals that high expression of SEMA6A is associated with poor prognosis in BRAF-mutant melanoma and plays a critical role in promoting tumor aggressiveness and resistance to targeted therapies. SEMA6A may serve as a potential predictor for the efficacy of dual BRAF/MEK inhibition.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Fabiana Conciatori, Erica Salvati, Ludovica Ciuffreda, Senji Shirasawa, Italia Falcone, Francesco Cognetti, Gianluigi Ferretti, Massimo Zeuli, Donatella Del Bufalo, Chiara Bazzichetto, Michele Milella
Summary: Soluble factors produced by stromal fibroblasts can influence the sensitivity of tumor cells to molecularly targeted drugs. This influence depends on the genetic mutations and PTEN protein status of the tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sara Ungania, Marco D'Arienzo, Sandro Nocentini, Marco D'Andrea, Vicente Bruzzaniti, Raffaella Marconi, Emilio Mezzenga, Bartolomeo Cassano, Erminia Infusino, Antonino Guerrisi, Antonella Soriani, Lidia Strigari
Summary: This study aimed to develop a SPECT/CT imaging protocol for quantitative imaging optimization in radioembolization (RE) treatment, using cutting edge imaging technology and a novel anthropomorphic 3D-printed phantom. The results showed that the xSPECT software allowed for absolute quantification in anthropomorphic geometry, but caution is needed when dealing with spherical objects with a necrotic core.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Antonello Vidiri, Andrea Ascione, Francesca Piludu, Eleonora Polito, Enzo Gallo, Renato Covello, Paola Nistico, Vittoria Balzano, Barbara Pichi, Raul Pellini, Simona Marzi
Summary: In this study, the correlation between imaging parameters obtained from magnetic resonance imaging (MRI) and pathological factors in oral cavity squamous cell carcinomas (OSCCs) was investigated. The results showed that pathological factors such as inflammatory infiltrate, tumor grading, and desmoplastic reaction affected the MRI parameters. Significant relationships were found between DKI parameters and tumor-infiltrating lymphocytes (TILs). Differences in DCE-MRI parameters were also observed according to tumor grading. These findings contribute to a better understanding of OSCCs and can be used for diagnostic and prognostic purposes.
Review
Cell Biology
Antonino Guerrisi, Italia Falcone, Fabio Valenti, Marco Rao, Enzo Gallo, Sara Ungania, Maria Teresa Maccallini, Maurizio Fanciulli, Pasquale Frascione, Aldo Morrone, Mauro Caterino
Summary: Artificial intelligence is increasingly being used in the field of medicine, particularly in the treatment of cancer. By processing large amounts of data, AI can assist clinicians in making more accurate treatment decisions, improving patient outcomes.
Review
Biochemistry & Molecular Biology
Elena Ricciardi, Elena Giordani, Giovanna Ziccheddu, Italia Falcone, Patrizio Giacomini, Maurizio Fanciulli, Michelangelo Russillo, Marianna Cerro, Gennaro Ciliberto, Aldo Morrone, Antonino Guerrisi, Fabio Valenti
Summary: Precision medicine has brought about a major change in the treatment of cancer, focusing on the individual and unique characteristics of each patient and tumor. Liquid biopsy, through the analysis of molecules and biomarkers in the blood, presents new opportunities in personalized medicine. Its easy application and lack of contraindications make it applicable in various fields. This review explores the applications and potential developments of liquid biopsy in metastatic melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Interdisciplinary Applications
Martina Betti, Chiara Maria Salzano, Alice Massacci, Mattia D'Antonio, Isabella Grassucci, Benedetta Marcozzi, Marco Canfora, Elisa Melucci, Simonetta Buglioni, Beatrice Casini, Enzo Gallo, Edoardo Pescarmona, Gennaro Ciliberto, Matteo Pallocca
Summary: The biomedical research field is advancing towards developing clinical trials and translational projects based on real-world evidence. To make this transition feasible, clinical centers need to work towards data accessibility and interoperability. This task is particularly challenging when applied to genomics, which has become routine through amplicon-based next-generation sequencing panels. These experiments produce numerous features per patient, and their results are often stored in static clinical reports, making critical information inaccessible to automated access and federated search consortia. This study presents a reanalysis of 4620 solid tumor sequencing samples in different histology settings and describes the bioinformatics and data engineering processes employed to create a somatic variant registry capable of dealing with the large biotechnological variability of routine genomics profiling.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Editorial Material
Oncology
Paolo Visca, Enzo Gallo, Mirella Marino
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sara Ungania, Francesco Maria Solivetti, Marco D'Arienzo, Francesco Quagliani, Isabella Sperduti, Aldo Morrone, Carlo de Mutiis, Vicente Bruzzaniti, Antonino Guerrisi
Summary: This study aimed to assess the image quality of reduced radiation dose CT images reconstructed with the ASiR-V algorithm and investigate the optimization of image quality parameters. The results showed that ASiR-V algorithm can provide high diagnostic quality images while reducing the patient dose. The best agreement was obtained for the images reconstructed using ASiR-V with NI24 and a high blending percentage (70-100%).
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, Research & Experimental
Patrizio Giacomini, Fabio Valenti, Matteo Allegretti, Matteo Pallocca, Francesca De Nicola, Ludovica Ciuffreda, Maurizio Fanciulli, Stefano Scalera, Simonetta Buglioni, Elisa Melucci, Beatrice Casini, Mariantonia Carosi, Edoardo Pescarmona, Elena Giordani, Francesca Sperati, Nicoletta Jannitti, Martina Betti, Marcello Maugeri-Sacca, Fabiana Letizia Cecere, Veronica Villani, Andrea Pace, Marialuisa Appetecchia, Patrizia Vici, Antonella Savarese, Eriseld Krasniqi, Virginia Ferraresi, Michelangelo Russillo, Alessandra Fabi, Lorenza Landi, Gabriele Minuti, Federico Cappuzzo, Massimo Zeuli, Gennaro Ciliberto
Summary: This study provides insights into the practices of Molecular Tumor Boards (MTB) in the real-world setting, discussing topics such as actionable alteration mapping and outcome metrics. The results show that a significant percentage of patients have actionable alterations, but many of them do not have access to the corresponding treatments. Additionally, combining tDNA and ctDNA testing can improve the detection rate of actionable alterations. It is suggested that better guidance and more efficient drug access channels are needed to improve treatment outcomes for patients with actionable but unexploited alterations.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Elisabetta Valentini, Marta Di Martile, Matteo Brignone, Marica Di Caprio, Isabella Manni, Michela Chiappa, Ilaria Sergio, Martina Chiacchiarini, Chiara Bazzichetto, Fabiana Conciatori, Simona D'Aguanno, Carmen D'Angelo, Rino Ragno, Michelangelo Russillo, Gianni Colotti, Francesco Marchesi, Maria Laura Bellone, Fabrizio Dal Piaz, Maria Pia Felli, Giovanna Damia, Donatella Del Bufalo
Summary: BH3 mimetics, which target the anti-apoptotic proteins of the Bcl-2 family, have shown promising therapeutic potential in cancer treatment. IS21, a novel pan BH3 mimetic, has been found to have preclinical antitumor activity in various types of tumors. IS21 demonstrated activity in T-cell acute lymphoblastic leukemia, melanoma, lung, pancreatic, and ovarian cancer cell lines.
CELL DEATH & DISEASE
(2023)
Article
Engineering, Electrical & Electronic
Alberto Sinibaldi, Matteo Allegretti, Norbert Danz, Elena Giordani, Peter Munzert, Agostino Occhicone, Patrizio Giacomini, Francesco Michelotti
Summary: ERBB2 is a major cancer driver and a recognized therapeutic target in many cancers, especially breast cancer. Researchers have developed a new approach using a direct competitive ERBB2 assay and 1-D photonic crystal-based biochips. These biochips allow label-free/fluorescence mode operation for ERBB2 biosensing in lysates from breast cancer cells and provide highly specific ERBB2 detection. The assay's main advantage is its single-step detection procedure, reducing assay turnaround time to less than 20 min, making it highly efficient for rapid detection of ERBB2 in complex biological media.
IEEE SENSORS LETTERS
(2023)
