Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release

The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

(2020) Shuang Rong et al.   Journal of Cachexia Sarcopenia and Muscle

Ketone Bodies Attenuate Wasting in Models of Atrophy

(2020) Andrew P. Koutnik et al.   Journal of Cachexia Sarcopenia and Muscle

KV11.1 Potassium Channel and the Na+/H+ Antiporter NHE1 Modulate Adhesion-Dependent Intracellular pH in Colorectal Cancer Cells

(2020) Jessica Iorio et al.   Frontiers in Pharmacology

Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial

(2020) Flávio D. Fuchs et al.   ACTA DIABETOLOGICA

Metabolic derangements of skeletal muscle from a murine model of glioma cachexia

(2019) Pengfei Cui et al.   Skeletal Muscle

Metabolic Profiling of Tumors, Sera, and Skeletal Muscles from an Orthotopic Murine Model of Gastric Cancer Associated-Cachexia

(2019) Pengfei Cui et al.   JOURNAL OF PROTEOME RESEARCH

Amelioration of muscle wasting by glucagon‐like peptide‐1 receptor agonist in muscle atrophy

(2019) Yeonhee Hong et al.   Journal of Cachexia Sarcopenia and Muscle

Mechanisms of insulin resistance by simvastatin in C2C12 myotubes and in mouse skeletal muscle

(2019) Gerda M. Sanvee et al.   BIOCHEMICAL PHARMACOLOGY

Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis‐associated cachexia

(2019) Wai W. Cheung et al.   Journal of Cachexia Sarcopenia and Muscle

Protein Profiling and Sizing of Extracellular Vesicles from Colorectal Cancer Patients via Flow Cytometry

(2018) Ye Tian et al.   ACS Nano

Cancer-associated cachexia

(2018) Vickie E. Baracos et al.   Nature Reviews Disease Primers

Emerging role of extracellular vesicles in mediating cancer cachexia

(2018) Sai V. Chitti et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Adipose tissue browning in cancer-associated cachexia can be attenuated by inhibition of exosome generation

(2018) Wenjun Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells

(2018) Jingxuan Yang et al.   GASTROENTEROLOGY

Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to promote tumour progression

(2018) Qi Wu et al.   Molecular Cancer

Inter-tissue communication in cancer cachexia

(2018) Josep M. Argilés et al.   Nature Reviews Endocrinology

Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90

(2017) Guohua Zhang et al.   Nature Communications

Significant natriuretic and antihypertensive action of the epithelial sodium channel blocker amiloride in diabetic patients with and without nephropathy

(2016) Henrik Andersen et al.   JOURNAL OF HYPERTENSION

Cytokine Signaling in Skeletal Muscle Wasting

(2016) Jin Zhou et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effectiveness of Chlorthalidone Plus Amiloride for the Prevention of Hypertension: The PREVER‐Prevention Randomized Clinical Trial

(2016) Sandra Costa Fuchs et al.   Journal of the American Heart Association

Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling

(2016) Xiangzheng Chen et al.   Journal of Cachexia Sarcopenia and Muscle

Understanding cachexia as a cancer metabolism syndrome

(2016) P E Porporato   Oncogenesis

Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue

(2015) Gunisha Sagar et al.   GUT

Cachexia: The last illness

(2015) Corie Lok   NATURE

Ghrelin prevents tumour- and cisplatin-induced muscle wasting: characterization of multiple mechanisms involved

(2015) Ji-an Chen et al.   Journal of Cachexia Sarcopenia and Muscle

Amiloride lowers blood pressure and attenuates urine plasminogen activation in patients with treatment–resistant hypertension

(2014) Christina S. Oxlund et al.   Journal of the American Society of Hypertension

Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7

(2014) W. A. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new look at an old drug for the treatment of cancer cachexia: Megestrol acetate

(2013) Josep M. Argilés et al.   CLINICAL NUTRITION

Modulating Roles of Amiloride in Irradiation-Induced Antiproliferative Effects in Glioblastoma Multiforme Cells Involving Akt Phosphorylation and the Alternative Splicing of Apoptotic Genes

(2013) Jen-Yang Tang et al.   DNA AND CELL BIOLOGY

Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

(2013) Sandra Palus et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amiloride Modulates Alternative Splicing in Leukemic Cells and ResensitizesBcr-AblT315I Mutant Cells to Imatinib

(2011) Wen-Hsin Chang et al.   CANCER RESEARCH

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

(2011) Rebecca A. Dragovic et al.   Nanomedicine-Nanotechnology Biology and Medicine

Reversing Cachexia

(2010) Michael J. Tisdale   CELL

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Megestrol acetate: Its impact on muscle protein metabolism supports its use in cancer cachexia

(2010) Sílvia Busquets et al.   CLINICAL NUTRITION

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE