Safety of Intravitreal Gene Therapy for Treatment of Subjects with Leber Hereditary Optic Neuropathy due to Mutations in the Mitochondrial ND4 Gene: The REVEAL Study

Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset

(2021) Nancy J. Newman et al.   OPHTHALMOLOGY

Factors associated with rapid improvement in visual acuity in patients with Leber's hereditary optic neuropathy after gene therapy

(2020) Hong‐li Liu et al.   ACTA OPHTHALMOLOGICA

Seven Years Follow-up of Gene Therapy for Leber's Hereditary Optic Neuropathy

(2020) Jiajia Yuan et al.   OPHTHALMOLOGY

Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress

(2020) Melissa L. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visual Outcomes in Leber Hereditary Optic Neuropathy Patients With the m.11778G>A (MTND4) Mitochondrial DNA Mutation

(2020) Nancy J. Newman et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy

(2020) Patrick Yu-Wai-Man et al.   Science Translational Medicine

Immune Response and Intraocular Inflammation in Patients With Leber Hereditary Optic Neuropathy Treated With Intravitreal Injection of Recombinant Adeno-Associated Virus 2 Carrying the ND4 Gene

(2019) Céline Bouquet et al.   JAMA Ophthalmology

International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy

(2017) Valerio Carelli et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors

(2017) Brian Zingg et al.   NEURON

Gene Therapy for Leber Hereditary Optic Neuropathy

(2017) John Guy et al.   OPHTHALMOLOGY

A neurodegenerative perspective on mitochondrial optic neuropathies

(2016) Patrick Yu-Wai-Man et al.   ACTA NEUROPATHOLOGICA

Gene Therapy for Leber Hereditary Optic Neuropathy

(2016) William J. Feuer et al.   OPHTHALMOLOGY

Visual BOLD Response in Late Blind Subjects with Argus II Retinal Prosthesis

(2016) E. Castaldi et al.   PLOS BIOLOGY

Long-term outcomes of gene therapy for the treatment of Leber's hereditary optic neuropathy

(2016) Shuo Yang et al.   EBioMedicine

ISCEV Standard for full-field clinical electroretinography (2015 update)

(2014) Daphne L. McCulloch et al.   DOCUMENTA OPHTHALMOLOGICA

Trial End Points and Natural History in Patients With G11778A Leber Hereditary Optic Neuropathy

(2014) Byron L. Lam et al.   JAMA Ophthalmology

A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy

(2011) Thomas Klopstock et al.   BRAIN

Leber’s Hereditary Optic Neuropathy

(2010) Alfredo A. Sadun et al.   Current Treatment Options in Neurology

Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside

(2010) Rajeshwari D. Koilkonda et al.   Journal of Ophthalmology

ISCEV Standard for full-field clinical electroretinography (2008 update)

(2008) M. F. Marmor et al.   DOCUMENTA OPHTHALMOLOGICA

Inherited mitochondrial optic neuropathies

(2008) P Yu-Wai-Man et al.   JOURNAL OF MEDICAL GENETICS