Phosphoinositide 3-Kinase p110 Delta Differentially Restrains and Directs Naïve Versus Effector CD8+ T Cell Transcriptional Programs

FOXO1 constrains activation and regulates senescence in CD8 T cells

(2021) Arnaud Delpoux et al.   Cell Reports

PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells

(2021) Daisy H. Luff et al.   Frontiers in Immunology

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

(2020) Julia M Marchingo et al.   eLife

Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells

(2020) Jens Eberlein et al.   JOURNAL OF IMMUNOLOGY

Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection

(2020) Ioana Sandu et al.   Cell Reports

Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation

(2020) Marcos P. Damasio et al.   BIOCHEMICAL JOURNAL

Targeting PI3K in cancer: mechanisms and advances in clinical trials

(2019) Jing Yang et al.   Molecular Cancer

4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance Tissue-Resident Memory T Cell Formation during Respiratory Influenza Infection

(2019) Angela C. Zhou et al.   JOURNAL OF IMMUNOLOGY

Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of PIK3CD-encoded phosphoinositide 3-kinase δ

(2019) David J Swan et al.   HAEMATOLOGICA

SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer

(2019) Burcu Yigit et al.   Cancer Immunology Research

Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

(2019) Andrew J. M. Howden et al.   NATURE IMMUNOLOGY

Primary immunodeficiency disorder caused by phosphoinositide 3-kinase delta (PI3Kδ) deficiency

(2018) Georgios Sogkas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

(2018) Christina M. Rollings et al.   Science Signaling

Foxo transcription factors in T cell biology and tumor immunity

(2018) Chong T. Luo et al.   SEMINARS IN CANCER BIOLOGY

Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1

(2018) Daniel T. Utzschneider et al.   Cell Reports

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

(2018) Christina M. Rollings et al.   Science Signaling

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

(2018) Anne-Katrien Stark et al.   Nature Communications

CD8 + T Cells Orchestrate pDC-XCR1 + Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming

(2017) Anna Brewitz et al.   IMMUNITY

Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung

(2017) A C Zhou et al.   Mucosal Immunology

FOXO1 opposition of CD8+T cell effector programming confers early memory properties and phenotypic diversity

(2017) Arnaud Delpoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MultiQC: summarize analysis results for multiple tools and samples in a single report

(2016) Philip Ewels et al.   BIOINFORMATICS

Slamf6 negatively regulates autoimmunity

(2016) Ninghai Wang et al.   CLINICAL IMMUNOLOGY

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8 + T Cells

(2016) Sarah H. Ross et al.   IMMUNITY

ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation

(2015) Erica L. Stone et al.   IMMUNITY

The cytotoxic T cell proteome and its shaping by the kinase mTOR

(2015) Jens L Hukelmann et al.   NATURE IMMUNOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Signaling in Lymphocyte Activation

(2015) Doreen Cantrell   Cold Spring Harbor Perspectives in Biology

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

(2014) Matthew M. Staron et al.   IMMUNITY

A “Proteomic Ruler” for Protein Copy Number and Concentration Estimation without Spike-in Standards

(2014) Jacek R. Wiśniewski et al.   MOLECULAR & CELLULAR PROTEOMICS

Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors

(2014) R. Dienstmann et al.   MOLECULAR CANCER THERAPEUTICS

Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model

(2014) S. Chen et al.   Cancer Immunology Research

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

(2013) Carrie L Lucas et al.   NATURE IMMUNOLOGY

Phosphoinositide 3-Kinase   Gene Mutation Predisposes to Respiratory Infection and Airway Damage

(2013) I. Angulo et al.   SCIENCE

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances

(2012) Lomon So et al.   BIOCHEMICAL JOURNAL

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signal Integration by Akt Regulates CD8 T Cell Effector and Memory Differentiation

(2012) E. H. Kim et al.   JOURNAL OF IMMUNOLOGY

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

(2011) Andrew N. Macintyre et al.   IMMUNITY

Inflammatory cytokines as a third signal for T cell activation

(2010) Julie M Curtsinger et al.   CURRENT OPINION IN IMMUNOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

T cells requireFoxo1to populate the peripheral lymphoid organs

(2009) Melanie R. Gubbels Bupp et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance

(2009) Weiming Ouyang et al.   IMMUNITY

Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation

(2009) C. Waugh et al.   MOLECULAR AND CELLULAR BIOLOGY

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

(2009) Yann M Kerdiles et al.   NATURE IMMUNOLOGY

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

(2008) Linda V Sinclair et al.   NATURE IMMUNOLOGY