Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma

RRx-001 ameliorates inflammatory diseases by acting as a potent covalent NLRP3 inhibitor

(2021) Yun Chen et al.   Cellular & Molecular Immunology

Allergic Endotypes and Phenotypes of Asthma

(2020) Nicole Akar-Ghibril et al.   Journal of Allergy and Clinical Immunology-In Practice

EphA2 phosphorylates NLRP 3 and inhibits inflammasomes in airway epithelial cells

(2020) Ao Zhang et al.   EMBO REPORTS

Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity

(2020) Yi Huang et al.   NATURE CELL BIOLOGY

Bringing asthma care into the twenty-first century

(2020) Kjell Larsson et al.   npj Primary Care Respiratory Medicine

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Apolipoprotein E is a Concentration-dependent Pulmonary Danger Signal that Activates the NLRP3 Inflammasome and IL-1β Secretion by Asthmatic Macrophages

(2019) Elizabeth M. Gordon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RRx-001 Acts as a Dual Small Molecule Checkpoint Inhibitor by Downregulating CD47 on Cancer Cells and SIRP-α on Monocytes/Macrophages

(2019) Pedro Cabrales   Translational Oncology

Targeting NLRP3 Inflammasome Activation in Severe Asthma

(2019) Efthymia Theofani et al.   Journal of Clinical Medicine

NLRP3 regulates macrophage M2 polarization through up-regulation of IL-4 in asthma

(2018) Ying Liu et al.   BIOCHEMICAL JOURNAL

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation

(2018) Lixia Wang et al.   Journal of Immunology Research

Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice

(2018) Hern-Tze Tina Tan et al.   ALLERGY

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Allergen-induced airway responses

(2015) Gail M. Gauvreau et al.   EUROPEAN RESPIRATORY JOURNAL

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Functional relevance of NLRP3 inflammasome-mediated interleukin (IL)-1β during acute allergic airway inflammation

(2014) M. Ritter et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

(2014) S R Kim et al.   Cell Death & Disease

The NLRP3 inflammasome: role in airway inflammation

(2013) H. Im et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

(2013) J. L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

Innate and adaptive immune responses in asthma

(2012) Stephen T Holgate   NATURE MEDICINE

The airway epithelium in asthma

(2012) Bart N Lambrecht et al.   NATURE MEDICINE

NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant

(2011) A.-G. Besnard et al.   ALLERGY

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

Allergen-specific pattern recognition receptor pathways

(2010) Marsha Wills-Karp   CURRENT OPINION IN IMMUNOLOGY

The Nlrp3 Inflammasome Affects Airway Inflammation, IgE/IL-13 Production And Mast Cell Function In A Subchronic Model Of Asthma

(2010) M. Kwan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The NLRP3 inflammasome: A sensor of immune danger signals

(2009) Suzanne L. Cassel et al.   SEMINARS IN IMMUNOLOGY

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE