What is hydroxynorketamine and what can it bring to neurotherapeutics?

(R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function

(2014) Rajib K. Paul et al.   ANESTHESIOLOGY

Activation of Mammalian Target of Rapamycin and Synaptogenesis: Role in the Actions of Rapid-Acting Antidepressants

(2013) Jason M. Dwyer et al.   BIOLOGICAL PSYCHIATRY

Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells

(2013) Nagendra S. Singh et al.   CELLULAR SIGNALLING

Neuronal D-Serine and Glycine Release Via the Asc-1 Transporter Regulates NMDA Receptor-Dependent Synaptic Activity

(2013) D. Rosenberg et al.   JOURNAL OF NEUROSCIENCE

Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors

(2012) Ruin Moaddel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gabapentin and (S)-pregabalin decrease intracellular d-serine concentrations in PC-12 cells

(2012) Nagendra S. Singh et al.   NEUROSCIENCE LETTERS

Stereoselective and regiospecific hydroxylation of ketamine and norketamine

(2012) Zeruesenay Desta et al.   XENOBIOTICA

Ketamine: new uses for an old drug?

(2011) K. Hirota et al.   BRITISH JOURNAL OF ANAESTHESIA

Inhibition of Human Serine Racemase, an Emerging Target for Medicinal Chemistry

(2011) Jana Jiraskova-Vanickova et al.   CURRENT DRUG TARGETS

Advances in Translational Neuropathic Research: Example of Enantioselective Pharmacokinetic–Pharmacodynamic Modeling of Ketamine-induced Pain Relief in Complex Regional Pain Syndrome

(2011) Michael Sabia et al.   Current Pain and Headache Reports

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

D-Serine Regulation: A Possible Therapeutic Approach for Central Nervous Diseases and Chronic Pain

(2009) R. Sethuraman et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Glutamate-based antidepressants: 20 years on

(2009) Phil Skolnick et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

d-Amino acids in the brain: d-serine in neurotransmission and neurodegeneration

(2008) Herman Wolosker et al.   FEBS Journal