A Role for Folate in Microbiome-Linked Control of Autoimmunity

Pros and Cons: Is Fecal Microbiota Transplantation a safe and efficient treatment option for gutdysbiosis?

(2021) Tom Marrs et al.   ALLERGY

Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis

(2021) Petri Elo et al.   Journal of Neuroinflammation

Immune Privilege: The Microbiome and Uveitis

(2021) Christine Mölzer et al.   Frontiers in Immunology

Short chain fatty acids inhibit endotoxin-induced uveitis and inflammatory responses of retinal astrocytes

(2021) Nu Chen et al.   EXPERIMENTAL EYE RESEARCH

Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis

(2021) Anna Ratsika et al.   Nutrients

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

B vitamin acquisition by gut commensal bacteria

(2020) Emily E. Putnam et al.   PLoS Pathogens

Meta-Analysis of Changes in the Number and Proportion of Regulatory T Cells in Patients with Ankylosing Spondylitis

(2020) Ming Li et al.   Biomed Research International

The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis

(2020) Sandra Dedrick et al.   Frontiers in Endocrinology

Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease

(2020) Zi Ye et al.   Gut Microbes

The microbiome in rheumatology: Where are we and where should we go?

(2020) Julia Manasson et al.   ANNALS OF THE RHEUMATIC DISEASES

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

(2020) Alexander Duscha et al.   CELL

Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells

(2020) Elizabeth C. Rosser et al.   Cell Metabolism

Host–microbiota interactions in immune-mediated diseases

(2020) William E. Ruff et al.   NATURE REVIEWS MICROBIOLOGY

Maternal diet as a risk factor for primary congenital glaucoma and defects of the anterior segment of the eye in the National Birth Defects Prevention Study

(2020) Kristin J. Moore et al.   Birth Defects Research

Treatment With FoxP3+ Antigen-Experienced T Regulatory Cells Arrests Progressive Retinal Damage in a Spontaneous Model of Uveitis

(2020) Yi-Hsia Liu et al.   Frontiers in Immunology

Intestinal Microbes in Autoimmune and Inflammatory Disease

(2020) Wan-Jung H. Wu et al.   Frontiers in Immunology

Severity of Experimental Autoimmune Uveitis Is Reduced by Pretreatment with Live Probiotic Escherichia coli Nissle 1917

(2020) Otakar Dusek et al.   Cells

Nutritional challenges for older adults in Europe: current status and future directions

(2019) Laura Kehoe et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Folic acid deficiency and vision: a review

(2019) Ouafa Sijilmassi   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Retinoic acid‐induced autoantigen‐specific type 1 regulatory T cells suppress autoimmunity

(2019) Mathilde Raverdeau et al.   EMBO REPORTS

Emerging role of air pollution in autoimmune diseases

(2019) Chan-Na Zhao et al.   AUTOIMMUNITY REVIEWS

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

(2019) Mary Ellen Sanders et al.   Nature Reviews Gastroenterology & Hepatology

Adaptive and Innate Immunity in Psoriasis and Other Inflammatory Disorders

(2019) Michael P. Schön   Frontiers in Immunology

Pursuing Human-Relevant Gut Microbiota-Immune Interactions

(2019) Sean P. Spencer et al.   IMMUNITY

Connect between gut microbiome and diseases of the human eye

(2019) S Shivaji   JOURNAL OF BIOSCIENCES

Foxp3 Instability Helps tTregs Distinguish Self and Non-self

(2019) Zhongmei Zhang et al.   Frontiers in Immunology

Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis

(2019) Qin Zeng et al.   NEUROCHEMISTRY INTERNATIONAL

The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome

(2019) Claudia M. Trujillo-Vargas et al.   Ocular Surface

Resolution of uveitis

(2019) Gerhild Wildner et al.   Seminars in Immunopathology

Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors

(2019) Melinda A. Engevik et al.   Frontiers in Microbiology

miR-223-3p promotes autoreactive Th17 cell responses in experimental autoimmune uveitis (EAU) by inhibiting transcription factor FOXO3 expression

(2019) Yankai Wei et al.   FASEB JOURNAL

Autoimmunity, Autoinflammation, and Infection in Uveitis

(2018) John V. Forrester et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Fecal transplants in spondyloarthritis and uveitis

(2018) Rene Y. Choi et al.   CURRENT OPINION IN RHEUMATOLOGY

Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inflammatory Disease of the Eye

(2018) Sama Kalyana Chakravarthy et al.   INDIAN JOURNAL OF MICROBIOLOGY

Perinatal Origins of Adult Disease

(2018) Umberto Simeoni et al.   Neonatology

Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis

(2018) Emily Evans et al.   JAMA Neurology

Consensus proposal for taxonomy and definition of the autoinflammatory diseases (AIDs): a Delphi study

(2018) Eldad Ben-Chetrit et al.   ANNALS OF THE RHEUMATIC DISEASES

Dynamic DNA Methylation Changes of Tbx21 and Rorc during Experimental Autoimmune Uveitis in Mice

(2018) Yiguo Qiu et al.   MEDIATORS OF INFLAMMATION

Lack of short-chain fatty acids and overgrowth of opportunistic pathogens define dysbiosis of neuromyelitis optica spectrum disorders: A Chinese pilot study

(2018) Junli Gong et al.   Multiple Sclerosis Journal

Folate and epigenetics: why we should not forget bacterial biosynthesis

(2018) Dieuwertje E Kok et al.   Epigenomics

The microbiome and HLA-B27-associated acute anterior uveitis

(2018) James T. Rosenbaum et al.   Nature Reviews Rheumatology

Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals

(2018) Bonggi Lee et al.   Journal of Immunology Research

Intestinal dysbiosis and probiotic applications in autoimmune diseases

(2017) Gislane Lelis Vilela de Oliveira et al.   IMMUNOLOGY

Here, there and everywhere: T follicular helper cells on the move

(2017) Cindy S. Ma et al.   IMMUNOLOGY

Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets

(2017) Difeng Fang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

(2017) Viola Neudecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Relationship between CD4 Regulatory T Cells and Anergy In Vivo

(2017) Lokesh A. Kalekar et al.   JOURNAL OF IMMUNOLOGY

Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation

(2017) Brian Wai Chow et al.   NEURON

Macrophage physiology in the eye

(2017) Holly R Chinnery et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye

(2017) Jaeyoung Kim et al.   Nutrients

Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine

(2017) Yukiko K. Nakamura et al.   Scientific Reports

The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System

(2017) Annie Luo et al.   Frontiers in Immunology

Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells via both Histone Deacetylase Inhibition and G Protein-Coupled Receptor 109A Signaling

(2017) Maria M. M. Kaisar et al.   Frontiers in Immunology

Leaky Gut As a Danger Signal for Autoimmune Diseases

(2017) Qinghui Mu et al.   Frontiers in Immunology

Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?

(2017) Andrew L. Mellor et al.   Frontiers in Immunology

Microbiome and metabolic disease: revisiting the bacterial phylum Bacteroidetes

(2016) Elizabeth L. Johnson et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Folate-targeted nanoparticles for rheumatoid arthritis therapy

(2016) Eugénia Nogueira et al.   Nanomedicine-Nanotechnology Biology and Medicine

CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors

(2016) Lokesh A Kalekar et al.   NATURE IMMUNOLOGY

Risk of Ocular Complications in Patients with Noninfectious Intermediate Uveitis, Posterior Uveitis, or Panuveitis

(2016) Andrew D. Dick et al.   OPHTHALMOLOGY

The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis

(2016) Jarmila Heissigerova et al.   Journal of Immunology Research

Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

(2015) Reiko Horai et al.   IMMUNITY

Phenotype modifications of T-cells and their shift toward a Th2 response in patients with systemic lupus erythematosus supplemented with different monthly regimens of vitamin D

(2015) S Piantoni et al.   LUPUS

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

(2015) Panagiotis S. Kabouridis et al.   NEURON

A gut-vascular barrier controls the systemic dissemination of bacteria

(2015) Ilaria Spadoni et al.   SCIENCE

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Homocysteine and the risk of age-related macular degeneration: a systematic review and meta-analysis

(2015) Peirong Huang et al.   Scientific Reports

MicroRNA-223 Regulates the Differentiation and Function of Intestinal Dendritic Cells and Macrophages by Targeting C/EBPβ

(2015) Haibo Zhou et al.   Cell Reports

Folate is absorbed across the human colon: evidence by using enteric-coated caplets containing 13C-labeled [6S]-5-formyltetrahydrofolate

(2014) Alanna Lakoff et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity

(2014) Xudong Li et al.   CELL

Relationship between homocysteine level and diabetic retinopathy: a systematic review and meta-analysis

(2014) Chong Xu et al.   Diagnostic Pathology

Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease

(2014) Lindsey G. Albenberg et al.   GASTROENTEROLOGY

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF- -Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

(2014) S. Xiao et al.   JOURNAL OF IMMUNOLOGY

The Treg-Specific Demethylated Region Stabilizes Foxp3 Expression Independently of NF-κB Signaling

(2014) Lisa Schreiber et al.   PLoS One

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut

(2014) A. M. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian gut immunity

(2014) Matam Vijay-Kumar et al.   Biomedical Journal

Folate receptor-targeted aminopterin therapy is highly effective and specific in experimental models of autoimmune uveitis and autoimmune encephalomyelitis

(2013) Yingjuan Lu et al.   CLINICAL IMMUNOLOGY

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and variations of homocysteine concentrations in patients with Behcet's disease

(2013) M. Messedi et al.   GENE

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen

(2013) Reiko Horai et al.   JOURNAL OF AUTOIMMUNITY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Mimicry epitope from Ehrlichia canis for interphotoreceptor retinoid-binding protein 201–216 prevents autoimmune uveoretinitis by acting as altered peptide ligand

(2013) Arunakumar Gangaplara et al.   JOURNAL OF NEUROIMMUNOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

A novel splice variant of folate receptor 4 predominantly expressed in regulatory T cells

(2012) Yi Tian et al.   BMC IMMUNOLOGY

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

(2012) Takahisa Miyao et al.   IMMUNITY

Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

(2012) M. Kinoshita et al.   JOURNAL OF IMMUNOLOGY

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(2012) Shohreh Issazadeh-Navikas et al.   MOLECULAR MEDICINE

G protein-coupled receptors for energy metabolites as new therapeutic targets

(2012) Clara C. Blad et al.   NATURE REVIEWS DRUG DISCOVERY

A Pivotal Role of Vitamin B9 in the Maintenance of Regulatory T Cells In Vitro and In Vivo

(2012) Jun Kunisawa et al.   PLoS One

Cancer risk with folic acid supplements: a systematic review and meta-analysis

(2012) Tale Norbye Wien et al.   BMJ Open

Arthritogenic Self-Reactive CD4+ T Cells Acquire an FR4hiCD73hi Anergic State in the Presence of Foxp3+ Regulatory T Cells

(2011) R. J. Martinez et al.   JOURNAL OF IMMUNOLOGY

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

Folate Production by Probiotic Bacteria

(2011) Maddalena Rossi et al.   Nutrients

Human Folate Bioavailability

(2011) Veronica E. Ohrvik et al.   Nutrients

The Multicenter Uveitis Steroid Treatment Trial: Rationale, Design, and Baseline Characteristics

(2010)   AMERICAN JOURNAL OF OPHTHALMOLOGY

Induction of T cell anergy: integration of environmental cues and infectious tolerance

(2010) Pascal Chappert et al.   CURRENT OPINION IN IMMUNOLOGY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Folate is absorbed across the colon of adults: evidence from cecal infusion of 13C-labeled [6S]-5-formyltetrahydrofolic acid

(2009) Susanne Aufreiter et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity

(2009) C. Schmidl et al.   GENOME RESEARCH

The Gut Immune Barrier and the Blood-Brain Barrier: Are They So Different?

(2009) Richard Daneman et al.   IMMUNITY

A Novel Splice Variant of FR4 Predominantly Expressed in CD4+CD25+Regulatory T Cells#

(2009) Zhengcai Jia et al.   IMMUNOLOGICAL INVESTIGATIONS

Mechanisms maintaining peripheral tolerance

(2009) Daniel L Mueller   NATURE IMMUNOLOGY

Methotrexate for Ocular Inflammatory Diseases

(2009) Sapna Gangaputra et al.   OPHTHALMOLOGY

A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages

(2008) W. Xia et al.   BLOOD

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Plasmacytoid Dendritic Cells Mediate Oral Tolerance

(2008) Anne Goubier et al.   IMMUNITY

The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier

(2008) R. Zhao et al.   MOLECULAR PHARMACOLOGY