Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention

CXCL17-mediated downregulation of type I collagen via MMP1 and miR-29 in skin fibroblasts possibly contributes to the fibrosis in systemic sclerosis

(2020) Shuichi Shimada et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Matrix Metalloproteinases MMP-2 and MMP-9, Their Inhibitors TIMP-1 and TIMP-2, Vascular Endothelial Growth Factor and sVEGFR-2 as Predictive Markers of Ischemic Retinopathy in Patients with Systemic Sclerosis—Case Series Report

(2020) Arleta Waszczykowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3).

(2019) Sandra Cabrera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma

(2019) Gregg B. Fields   Cells

The Versatile Role of Matrix Metalloproteinase for the Diverse Results of Fibrosis Treatment

(2019) Hong-Meng Chuang et al.   MOLECULES

Extracellular matrix as a driver of progressive fibrosis

(2018) Jeremy Herrera et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanosensing and fibrosis

(2018) Daniel J. Tschumperlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Ongoing clinical trials and treatment options for patients with systemic sclerosis–associated interstitial lung disease

(2018) Dinesh Khanna et al.   RHEUMATOLOGY

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Matrix Stiffness: the Conductor of Organ Fibrosis

(2018) Alba Santos et al.   Current Rheumatology Reports

New insights into the genetics and epigenetics of systemic sclerosis

(2018) Chiara Angiolilli et al.   Nature Reviews Rheumatology

Unraveling SSc Pathophysiology; The Myofibroblast

(2018) Arjan van Caam et al.   Frontiers in Immunology

The instructive extracellular matrix of the lung: basic composition and alterations in chronic lung disease

(2017) Gerald Burgstaller et al.   EUROPEAN RESPIRATORY JOURNAL

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

(2017) David Lagares et al.   Science Translational Medicine

Matrix Metalloproteinases-7 and Kidney Fibrosis

(2017) Ben Ke et al.   Frontiers in Physiology

Update of EULAR recommendations for the treatment of systemic sclerosis

(2016) Otylia Kowal-Bielecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Prostaglandin E2inhibits collagen synthesis in dermal fibroblasts and prevents hypertrophic scar formationin vivo

(2016) Jingling Zhao et al.   EXPERIMENTAL DERMATOLOGY

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin

(2016) Paola Zigrino et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genetics of systemic sclerosis

(2015) Paula S. Ramos et al.   CURRENT OPINION IN RHEUMATOLOGY

Multilevel regulation of matrix metalloproteinases in tissue homeostasis indicates their molecular specificity in vivo

(2015) Jean Gaffney et al.   MATRIX BIOLOGY

Matrix Metalloproteinases in Inflammatory Bowel Disease: An Update

(2015) Shane O’Sullivan et al.   MEDIATORS OF INFLAMMATION

Systemic sclerosis

(2015) Yannick Allanore et al.   Nature Reviews Disease Primers

Metalloproteinases and Wound Healing

(2015) Matthew P. Caley et al.   Advances in Wound Care

Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels

(2014) Tetsu Kobayashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies

(2014) Nezam Altorok et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibitory effects of prostaglandin E2on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma

(2014) Ewa Pomianowska et al.   BMC CANCER

Diverse functions of matrix metalloproteinases during fibrosis

(2014) M. Giannandrea et al.   Disease Models & Mechanisms

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

(2014) Matthew W. Parker et al.   JOURNAL OF CLINICAL INVESTIGATION

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Mononuclear Phagocytes and Airway Epithelial Cells: Novel Sources of Matrix Metalloproteinase-8 (MMP-8) in Patients with Idiopathic Pulmonary Fibrosis

(2014) Vanessa J. Craig et al.   PLoS One

MMP-12 Deficiency Attenuates Angiotensin II-Induced Vascular Injury, M2 Macrophage Accumulation, and Skin and Heart Fibrosis

(2014) Lukasz Stawski et al.   PLoS One

MiR-29a Reduces TIMP-1 Production by Dermal Fibroblasts via Targeting TGF-β Activated Kinase 1 Binding Protein 1, Implications for Systemic Sclerosis

(2014) Marzena Ciechomska et al.   PLoS One

Kidney involvement in systemic sclerosis

(2014) Virginia D. Steen   PRESSE MEDICALE

Quantitating Skin Fibrosis: Innovative Strategies and Their Clinical Implications

(2014) Giuseppina Abignano et al.   Current Rheumatology Reports

Review: Interstitial Lung Disease Associated With Systemic Sclerosis and Idiopathic Pulmonary Fibrosis: How Similar and Distinct?

(2014) Erica L. Herzog et al.   Arthritis & Rheumatology

Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis and hypersensitivity pneumonitis

(2013) AWuyts Wim et al.   Annals of Thoracic Medicine

Genetics of scleroderma: implications for personalized medicine?

(2013) Shervin Assassi et al.   BMC Medicine

Role of microRNA-mediated MMP regulation in the treatment and diagnosis of malignant tumors

(2013) Liqin Li et al.   CANCER BIOLOGY & THERAPY

Angiotensin-II induced hypertension and renovascular remodelling in tissue inhibitor of metalloproteinase 2 knockout mice

(2013) Sathnur Pushpakumar et al.   JOURNAL OF HYPERTENSION

Profibrotic Activities for Matrix Metalloproteinase-8 during Bleomycin-Mediated Lung Injury

(2013) V. J. Craig et al.   JOURNAL OF IMMUNOLOGY

IL-13 Promotes Collagen Accumulation in Crohn’s Disease Fibrosis by Down-Regulation of Fibroblast MMP Synthesis: A Role for Innate Lymphoid Cells?

(2013) Jennifer R. Bailey et al.   PLoS One

Pivotal Role of Matrix Metalloproteinase 13 in Extracellular Matrix Turnover in Idiopathic Pulmonary Fibrosis

(2013) Takwi Nkyimbeng et al.   PLoS One

Matrix Metalloproteinase-19 Is a Key Regulator of Lung Fibrosis in Mice and Humans

(2012) Guoying Yu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage

(2012) Mirko Manetti et al.   ANNALS OF THE RHEUMATIC DISEASES

Abnormal collagen V deposition in dermis correlates with skin thickening and disease activity in systemic sclerosis

(2012) Patricia Martin et al.   AUTOIMMUNITY REVIEWS

Supernatants from culture of type I collagen-stimulated PBMC from patients with cutaneous systemic sclerosis versus localized scleroderma demonstrate suppression of MMP-1 by fibroblasts

(2012) Monica Brown et al.   CLINICAL RHEUMATOLOGY

Differential gene expression of MMP-1, TIMP-1 and HGF in clinically involved and uninvolved skin in South Africans with SSc

(2012) J. Frost et al.   RHEUMATOLOGY

microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma

(2012) T. Sing et al.   RHEUMATOLOGY

Matrix Metalloproteinase 3 Is a Mediator of Pulmonary Fibrosis

(2011) Cory M. Yamashita et al.   AMERICAN JOURNAL OF PATHOLOGY

Localized expression of tenascin in systemic sclerosis-associated pulmonary fibrosis and its regulation by insulin-like growth factor binding protein 3

(2011) Monique Brissett et al.   ARTHRITIS AND RHEUMATISM

Metalloproteinases in idiopathic pulmonary fibrosis

(2011) R. C. A. Dancer et al.   EUROPEAN RESPIRATORY JOURNAL

Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement

(2011) Pia Moinzadeh et al.   EXPERIMENTAL DERMATOLOGY

Angiotensin-II and rosuvastatin influence matrix remodeling in human mesangial cells via metalloproteinase modulation

(2011) Anna Solini et al.   JOURNAL OF HYPERTENSION

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biological role of matrix metalloproteinases: a critical balance

(2010) S. Loffek et al.   EUROPEAN RESPIRATORY JOURNAL

Deficiency of matrix metalloproteinase-13 increases inflammation after acute lung injury

(2010) Anita I. Sen et al.   EXPERIMENTAL LUNG RESEARCH

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4

(2010) Dianhua Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases and Attenuates IL-13-Dependent Fibrosis

(2010) S. K. Madala et al.   JOURNAL OF IMMUNOLOGY

Association of a Functional Polymorphism in the Matrix Metalloproteinase-12 Promoter Region with Systemic Sclerosis in an Italian Population

(2010) M. MANETTI et al.   JOURNAL OF RHEUMATOLOGY

Broad-Spectrum Matrix Metalloproteinase Inhibition Curbs Inflammation and Liver Injury but Aggravates Experimental Liver Fibrosis in Mice

(2010) Vincent E. de Meijer et al.   PLoS One

Resistance to Bleomycin-Induced Lung Fibrosis in MMP-8 Deficient Mice Is Mediated by Interleukin-10

(2010) Emilio García-Prieto et al.   PLoS One

Matrilysin (Matrix Metalloproteinase-7) Regulates Anti-Inflammatory and Antifibrotic Pulmonary Dendritic Cells That Express CD103 (αEβ7-Integrin)

(2009) Anne M. Manicone et al.   AMERICAN JOURNAL OF PATHOLOGY

Systemic Sclerosis: Environmental Factors

(2009) G. F. MORA   JOURNAL OF RHEUMATOLOGY

Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis

(2009) Christian Beyer et al.   ARTHRITIS RESEARCH & THERAPY

Transgenic Expression of Matrix Metalloproteinase-1 Inhibits Myocardial Fibrosis and Prevents the Transition to Heart Failure in a Pressure Overload Mouse Model

(2008) Robert F Foronjy et al.   HYPERTENSION RESEARCH

Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis

(2008) A G Richter et al.   THORAX