Article
Biochemistry & Molecular Biology
Thomas E. Zapadka, Sarah I. Lindstrom, Julia C. Batoki, Chieh A. Lee, Brooklyn E. Taylor, Scott J. Howell, Patricia R. Taylor
Summary: The study examined the efficacy of an AhR agonist, VAF347, as a potential therapeutic for non-proliferative diabetic retinopathy. It was found that the AhR agonist significantly reduced leukostasis, oxidative stress, and inflammation in the retina of diabetic mice, and ameliorated retinal capillary degeneration. These findings suggest that VAF347 could be a potentially novel therapeutic for non-proliferative diabetic retinopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Chaiara Bianca Maria Platania, Filippo Drago, Claudio Bucolo
Summary: The activation of P2X7 receptor is implicated in the pathophysiology of various retinal age-related diseases, making it a potential pharmacological target for preventing these devastating conditions.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xudong Wang, Tianxi Wang, Enton Lam, David Alvarez, Ye Sun
Summary: The eye has immune privilege to protect retinal neural cells from immune provocation. However, breach of this privilege can lead to acute inflammatory responses and chronic inflammation, causing ocular diseases and vision loss. This review discusses the features of immune privilege in the retina, the inflammatory responses and factors involved when immune privilege fails, as well as recent advances in ocular immunity and ocular vascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Shuo Yang, Shounan Qi, Chenguang Wang
Summary: Diabetic retinopathy is a significant complication of diabetes, and the activation and changes in retinal Muller cells play a crucial role in its pathogenesis. Understanding the involvement of Muller cells can provide new targets for the treatment of diabetic retinopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Aicha Saadane, Alexander A. Veenstra, Martin S. Minns, Jie Tang, Yunpeng Du, Fatima Abubakr Elghazali, Emma M. Lessieur, Eric Pearlman, Timothy S. Kern
Summary: Inflammatory monocytes play a critical role in the early development of diabetic retinopathy.
Article
Immunology
Edoardo Midena, Tommaso Torresin, Erika Velotta, Elisabetta Pilotto, Raffaele Parrozzani, Luisa Frizziero
Summary: Optical coherence tomography (OCT) allows for the identification of clinical biomarkers in retinal diseases, such as aggregates of activated microglial cells. A semi-automatic method has been developed to reliably quantify hyperreflective retinal foci (HRF), particularly in diabetic retinopathy (DR), providing valuable insights into the inflammatory component of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Lei Tang, Chaoyang Zhang, Qian Yang, Hai Xie, Dandan Liu, Haibin Tian, Lixia Lu, Jing-Ying Xu, Weiye Li, Guoxu Xu, Qinghua Qiu, Kun Liu, Dawei Luo, Guo-Tong Xu, Jingfa Zhang
Summary: Melatonin has protective effects on the inner blood-retinal barrier in diabetic retinopathy by regulating the expression of inflammatory factors and tight junction proteins. This study provides insights into the development of melatonin-based therapy for diabetic retinopathy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Matteo Stravalaci, Mariantonia Ferrara, Varun Pathak, Francesca Davi, Barbara Bottazzi, Alberto Mantovani, Reinhold J. Medina, Mario R. Romano, Antonio Inforzato
Summary: Age related macular degeneration (AMD) and diabetic retinopathy (DR) are neurodegenerative and inflammatory diseases of the eye. Both diseases involve cellular components of the blood-retina barrier (BRB) and share common drivers, such as chronic inflammation. Long pentraxin 3 (PTX3), a soluble pattern recognition molecule, is emerging as a potential therapeutic target in retinal diseases, as it plays a role in trapping complement and modulating inflammation at the BRB.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Wen Mei, Biao Zhu, Yi Shu, Yanhua Liang, Mei Lin, Mingjuan He, Haizhao Luo, Jingwen Ye
Summary: The study demonstrated that GDF11 treatment improved diabetes-induced retinal dysfunction in mice by protecting against cell death, capillary degeneration, inflammation, and inhibiting blood-retinal barrier breakdown. The mechanism of protection involves TGF-β/Smad2, PI3K-Akt-FoxO1 activation, and NF-κB pathway inhibition.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Qionghua Wang, Lanyue Zhang, Qiang Shen, Chunqin Zeng, Yanhong Fang, Kepeng Ou
Summary: This study demonstrated that the compound 5-Bromo3,4-dihydroxybenzaldehyde (BDB) derived from marine red algae has a protective effect on diabetic retinopathy (DR). BDB promotes vascular integrity, inhibits the transcription of proinflammatory factors, alleviates hyperglycemia-induced permeability, and protects retinal ganglion cells (RGC) from hyperglycemia-induced apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, General & Internal
Luisa Frizziero, Andrea Calciati, Giulia Midena, Tommaso Torresin, Raffaele Parrozzani, Elisabetta Pilotto, Edoardo Midena
Summary: Subthreshold micropulse laser treatment has shown potential in treating diabetic macular edema, but its mechanism of action and most effective treatment methods are not yet fully understood, requiring further research. The treatment appears to normalize specific retinal neuroinflammatory metabolic pathways long-term, contributing to the restoration of retinal homeostasis and the curtailing of local inflammatory processes. Optimized and standardized parameters are key to ensuring effective and safe treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Chunren Meng, Chufeng Gu, Shuai He, Tong Su, Thashi Lhamo, Deji Draga, Qinghua Qiu
Summary: Pyroptosis is an emerging type of inflammatory cell death that may play a crucial role in the development of diabetic retinopathy, potentially contributing to the destruction of retinal neurovascular unit cells in hyperglycemic conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
XingJie Su, XiaoTian Yang, HongWei Liu
Summary: Diabetic retinopathy (DR) is a major cause of visual impairment and blindness. This study investigated the involvement of lncRNA SPAG5-AS1 (SPAG5-AS1) in retinal vascular dysfunction under diabetic conditions. The results showed that SPAG5-AS1 attenuates diabetic retinal vascular dysfunction through the miR-1224-5p/IRS-1 axis, suggesting a potential therapeutic strategy for DR.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Heather Lyon, Avik Shome, Ilva D. Rupenthal, Colin R. Green, Odunayo O. Mugisho
Summary: The study demonstrated that tonabersat can inhibit inflammasome activation and proinflammatory cytokine release in diabetic retinopathy, showing potential for reducing inflammation in this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rocio Bautista-Perez, Agustina Cano-Martinez, Elisa Gutierrez-Velazquez, Martin Martinez-Rosas, Rosa M. Perez-Gutierrez, Francisco Jimenez-Gomez, Javier Flores-Estrada
Summary: The study demonstrated that SME could attenuate retinal degeneration in diabetic rats by reducing oxidative stress, inflammation, and apoptosis through inhibition of the CML-RAGE interaction.
Article
Cell Biology
Sigrun Sigurdardottir, Thomas E. Zapadka, Sarah Lindstrom, Haitao Liu, Brooklyn E. Taylor, Chieh A. Lee, Timothy S. Kern, Patricia R. Taylor
CELLULAR IMMUNOLOGY
(2019)
Article
Endocrinology & Metabolism
Sarah I. Lindstrom, Sigrun Sigurdardottir, Thomas E. Zapadka, Jie Tang, Haitao Liu, Brooklyn E. Taylor, Dawn G. Smith, Chieh A. Lee, John DeAngelis, Timothy S. Kern, Patricia R. Taylor
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Thomas E. Zapadka, Sarah I. Lindstrom, Brooklyn E. Taylor, Chieh A. Lee, Jie Tang, Zakary R. R. Taylor, Scott J. Howell, Patricia R. Taylor
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Thomas E. Zapadka, Sarah I. Lindstrom, Julia C. Batoki, Chieh A. Lee, Brooklyn E. Taylor, Scott J. Howell, Patricia R. Taylor
Summary: The study examined the efficacy of an AhR agonist, VAF347, as a potential therapeutic for non-proliferative diabetic retinopathy. It was found that the AhR agonist significantly reduced leukostasis, oxidative stress, and inflammation in the retina of diabetic mice, and ameliorated retinal capillary degeneration. These findings suggest that VAF347 could be a potentially novel therapeutic for non-proliferative diabetic retinopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Brooklyn E. Taylor, Chieh A. Lee, Thomas E. Zapadka, Amy Y. Zhou, Katherine G. Barber, Zakary R. R. Taylor, Scott J. Howell, Patricia R. Taylor
Summary: Retinal neovascularization is a common cause of vision loss in diseases such as proliferative diabetic retinopathy, neovascular glaucoma, and age-related macular degeneration. This study found that Interleukin-17A (IL-17A) plays a crucial role in the onset and progression of non-proliferative diabetic retinopathy. The researchers also discovered that IL-17A enhances vascular endothelial growth factor (VEGF) production, promotes retinal endothelial cell proliferation, and enhances VEGF-dependent vascular angiogenesis, ultimately leading to retinal neovascularization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)