Tonabersat Inhibits Connexin43 Hemichannel Opening and Inflammasome Activation in an In Vitro Retinal Epithelial Cell Model of Diabetic Retinopathy

To protect or adversely affect? The dichotomous role of the NLRP1 inflammasome in human disease

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Connexin43 hemichannel block protects against retinal pigment epithelial cell barrier breakdown

(2019) Charisse Kuo et al.   ACTA DIABETOLOGICA

Connexin Hemichannel Block Using Orally Delivered Tonabersat Improves Outcomes in Animal Models of Retinal Disease

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NLRP1 deficiency attenuates diabetic retinopathy (DR) in mice through suppressing inflammation response

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The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release

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Modulation of three key innate immune pathways for the most common retinal degenerative diseases

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Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function

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Kaempferol attenuates retinal ganglion cell death by suppressing NLRP1/NLRP3 inflammasomes and caspase-8 via JNK and NF-κB pathways in acute glaucoma

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Connexin43 hemichannel block protects against the development of diabetic retinopathy signs in a mouse model of the disease

(2018) Odunayo O. Mugisho et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels

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Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

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Macular atrophy in patients with long-term anti-VEGF treatment for neovascular age-related macular degeneration

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Retinal Ganglion Cell Layer Change in Patients Treated With Anti–Vascular Endothelial Growth Factor for Neovascular Age-related Macular Degeneration

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Effect of intravitreal anti-VEGF on choroidal thickness in patients with diabetic macular edema using spectral domain OCT

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Vascular Endothelial Growth Factor Inhibitors for Diabetic Retinopathy

(2016) Dilsher S. Dhoot et al.   Current Diabetes Reports

Anti–Vascular Endothelial Growth Factor Agents in the Treatment of Retinal Disease

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Five-Year Outcomes with Anti–Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration

(2016) Maureen G. Maguire et al.   OPHTHALMOLOGY

Connexin43 in retinal injury and disease

(2016) Helen V. Danesh-Meyer et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Cell communication across gap junctions: a historical perspective and current developments

(2015) W. Howard Evans   BIOCHEMICAL SOCIETY TRANSACTIONS

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

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Diabetic retinopathy: pathogenesis, clinical grading, management and future developments

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Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Blood-Retinal Barrier

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Regulatory mechanism of TNFα autoregulation in HaCaT cells: The role of the transcription factor EGR-1

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Interleukin-1-induced interleukin-6 synthesis is mediated by the neutral sphingomyelinase/Src kinase pathway in neurones

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