Article
Pathology
German Plascencia-Villa, George Perry
Summary: Alzheimer's disease is a chronic condition characterized by progressive decline in memory and cognition, which is closely associated with neuropathologic changes and hallmark lesions. Understanding the complex biological aspects of the disease is crucial, as these changes are not only the cause but also the collective response to the disease process that is essential for maintaining life during aging but ultimately leads to nonfunctional brain. Pathologic diagnosis of Alzheimer's disease remains the gold standard for precise diagnosis of dementia, commonly used in conjunction with cognitive-memory tests and brain imaging scans. This overview highlights the main neuropathologic features of Alzheimer's disease and sheds light on the key biological and functional changes that contribute to age-dependent brain failure related to the disease.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Cell Biology
Christian Humpel
Summary: Neurodegenerative brain disorders, such as Alzheimer's disease, pose a significant burden on society. Delivery of an amyloid-beta degrading enzyme, neprilysin, through the intranasal pathway has been found to eliminate amyloid-beta plaques in transgenic Alzheimer's disease mice. This method shows promise as an alternative approach for treating Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2022)
Review
Neurosciences
Johant Lakey-Beitia, Andrea M. Burillo, Giovanni La Penna, Muralidhar L. Hegde, K. S. Rao
Summary: Alzheimer's disease is a common neurodegenerative disease characterized by the aggregation of amyloid-beta, with metal dyshomeostasis playing a critical role in disease progression. Polyphenols, as natural chelators, have therapeutic effects such as antioxidant activity, metal chelation, improvement of mitochondrial function, and inhibition of amyloidogenesis, making them potential candidates for chelation-based therapy for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Quentin Gallet, Vincent Bouteloup, Maxime Locatelli, Marie-Odile Habert, Marie Chupin, Julien Delrieu, Thibaud Lebouvier, Gabriel Robert, Renaud David, Samuel Bulteau, Anna-Chloe Balageas, Alexandre Surget, Catherine Belzung, Nicolas Arlicot, Maria-Joao Ribeiro, Laurent Barantin, Frederic Andersson, Jean-Philippe Cottier, Valerie Gissot, Wissam El-Hage, Vincent Camus, Benedicte Gohier, Thomas Desmidt
Summary: Recent evidence suggests a connection between BZDs use and lower brain amyloid load, with potential effects on hippocampal volume and symptoms of depression, anxiety, and apathy. Additional research is needed to confirm the causal relationship and explore potential therapeutic targets for Alzheimer's disease.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Santiago Ramirez, Suelyn Koerich, Natalia Astudillo, Nicole De Gregorio, Rabab Al-Lahham, Tyler Allison, Natalia Pessoa Rocha, Fei Wang, Claudio Soto
Summary: This study aimed to evaluate the effect of removing Aβ from blood plasma on the accumulation of amyloid plaques in the brain. The results showed a reduction in Aβ levels in the plasma and insoluble brain fractions, as well as a decrease in amyloid plaque burden and changes in plaque size distribution in the cortex and hippocampus. These findings support the importance of targeting Aβ in the periphery and suggest plasma exchange as a potential non-pharmacological strategy for slowing down AD pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jong Youl Lee, Eun Ae Jeong, Jaewoong Lee, Hyun Joo Shin, So Jeong Lee, Hyeong Seok An, Kyung Eun Kim, Won-Ho Kim, Yong Chul Bae, Heeyoung Kang, Gu Seob Roh
Summary: Age-related microglial activation is associated with cognitive impairment. TonEBP plays important roles in age-related microglial activation and memory deficits. TonEBP haploinsufficiency reduces microglial activation, synaptic pruning, dendritic spine loss, and memory deficits in middle-aged and amyloid beta oligomer-treated mice. Additionally, TonEBP knockdown attenuates migration and phagocytosis in amyloid beta oligomer-treated BV2 cells.
Article
Pharmacology & Pharmacy
Mehrdad Jahanshahi, Masoumeh Khalili, Asra Margdari, Mahdi Aalikhani
Summary: This study demonstrates that naringin exhibits satisfying iron chelation capacity and has the potential to be a promising natural substitute for the treatment of iron overload disorders.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Neurosciences
Luca Biasetti, Stephanie Rey, Milena Fowler, Arjuna Ratnayaka, Kate Fennell, Catherine Smith, Karen Marshall, Catherine Hall, Mariana Vargas-Caballero, Louise Serpell, Kevin Staras
Summary: Alzheimer's disease is associated with increased levels of A beta in the brain, and this study investigates the impact of A beta on functional presynaptic vesicle pools. The researchers found that A beta treatment led to an enlargement of functional vesicles and an accumulation of recycled vesicles near endocytic sites. This resulted in deficits in vesicle retrieval pathways and limited information signaling capacity. Treatment with an antiepileptic drug partially rescued these transmission defects.
Article
Clinical Neurology
Tomas T. Roos, Megg G. Garcia, Isak Martinsson, Rana Mabrouk, Bodil Israelsson, Tomas Deierborg, Asgeir Kobro-Flatmoen, Heikki Tanila, Gunnar K. Gouras
Summary: Research suggests that intracellular A beta plays a crucial role in the prion-like spread of Alzheimer's disease, leading to plaque formation and neuronal damage.
ACTA NEUROPATHOLOGICA
(2021)
Article
Neurosciences
Wolfgang J. Streit, Jonas Rotter, Karsten Winter, Wolf Mueller, Habibeh Khoshbouei, Ingo Bechmann
Summary: This study explores the pathogenesis of neuritic plaques, finding that accumulations of iron and ferroptosis in the central nervous system trigger the formation of plaques. Microglial ferritin expression and A beta deposition both contribute to this process. Neurofibrillary tangles, on the other hand, are unlikely to involve the release of neuronal iron extracellularly.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Rathnam Mallesh, Juhee Khan, Krishnangsu Pradhan, Rajsekhar Roy, Nihar Ranjan Jana, Parasuraman Jaisankar, Surajit Ghosh
Summary: This study developed a series of fluorescent probes for the detection of amyloid beta aggregates in Alzheimer's disease. Among these probes, RM-28 showed excellent fluorescence properties, high sensitivity, and specificity.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
David Devos, Julien Labreuche, Olivier Rascol, Jean-Christophe Corvol, Alain Duhamel, P. Guyon Delannoy, Werner Poewe, Yaroslau Compta, Nicola Pavese, Evzen Ruzicka, Petr Dusek, Bart Post, Bastiaan R. Bloem, Daniela Berg, Walter Maetzler, Markus Otto, Marie-Odile Habert, Stephane Lehericy, Joaquim Ferreira, Richard Dodel, Christine Tranchant, Alexandre Eusebio, Stephane Thobois, Ana-Raquel Marques, Wassilios G. Meissner, Fabienne Ory-Magne, Uwe Walter, Rob M. A. de Bie, Miguel Gago, Dolores Vilas, Jaime Kulisevsky, Cristina Januario, Miguel V. S. Coelho, Stefanie Behnke, Paul Worth, Klaus Seppi, Thavarak Ouk, Camille Potey, Celine Leclercq, Romain Viard, Gregory Kuchcinski, Renaud Lopes, Jean-Pierre Pruvo, Pascal Pigny, Guillaume Garcon, Ophelie Simonin, Jessica Carpentier, Anne-Sophie Rolland, Dag Nyholm, Christoph Scherfler, Jean-Francois Mangin, Marie Chupin, Regis Bordet, David T. Dexter, Caroline Fradette, Michael Spino, Fernando Tricta, Scott Ayton, Ashley I. Bush, Jean-Christophe Devedjian, James A. Duce, Ioav Cabantchik, Luc Defebvre, Dominique Deplanque, Caroline Moreau
Summary: In a 36-week trial involving participants with early Parkinson's disease who had not received levodopa, treatment with the iron chelator deferiprone led to worse scores in measures of parkinsonism compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maite Solas, Silvia Vela, Cristian Smerdou, Eva Martisova, Ivan Martinez-Valbuena, Maria-Rosario Luquin, Maria J. Ramirez
Summary: c-Jun N-terminal kinase 3 (JNK3) is believed to be involved in the pathogenesis of AD, but it is unclear whether JNK or amyloid beta (Aβ) comes first in disease onset. This study found that pJNK expression is significantly increased in AD patients and Tg2576 mice, and there is a correlation and interaction between pJNK expression and Aβ levels in AD. Overexpression of JNK3 in the brain can induce cognitive deficiencies and Tau misfolding in AD mice, possibly triggered by increased Aβ.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Yuji Kamikubo, Hao Jin, Yiyao Zhou, Kazue Niisato, Yoshie Hashimoto, Nobumasa Takasugi, Takashi Sakurai
Summary: Alzheimer's disease is a progressive neurodegenerative brain disorder and the leading cause of dementia in the elderly. The characteristic features of the disease include the presence of senile plaques, neurofibrillary tangles, and cerebral atrophy. Various experimental models have been used to study the disease, but combining these models is necessary for a comprehensive understanding of its pathology.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Rikuya Yoshimura, Tomohiro Miyasaka, Satoru Funamoto, Takashi Saito, Takaomi C. C. Saido, Masaya Ikegawa, Nobuto Kakuda
Summary: The morphology of senile plaques in APP knock-in mice brain is influenced by the fixative used. Solid forms of senile plaques similar to those found in the brains of AD patients were observed in APP knock-in mice brain treated with formic acid, Davidson's fluid fixative, and Bouin's fluid fixative. A beta 42 was found as cored plaques, while A beta 38 accumulated around A beta 42.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Ali Ebrahimzadeh, Yaghoub Safdari, Masoumeh Khalili
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
(2015)
Review
Pharmacology & Pharmacy
Yaghoub Safdari, Masoumeh Khalili, Mohammad Ali Ebrahimzadeh, Yaghoub Yazdani, Safar Farajnia
PHARMACOLOGICAL RESEARCH
(2015)
Article
Fisheries
R. Safari, M. Khalili, M. Reza Imanpour, M. Pourkazemi
JOURNAL OF APPLIED ICHTHYOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Yaghoub Safdari, Vahideh Ahmadzadeh, Masoumeh Khalili, Hossein Zarei Jaliani, Vahid Zarei, Vahid Erfani-Moghadam
MOLECULAR MEDICINE
(2016)
Article
Neurosciences
M. Mirzaie, M. Khalili, Z. Kiasalari, M. Roghani
Article
Pharmacology & Pharmacy
Zahra Hashemi, Mohammad Ali Ebrahimzadeh, Masoumeh Khalili
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2019)
Article
Chemistry, Medicinal
Mahdi Aalikhani, Mehrdad Alikhani, Mehrdad Jahanshahi, Leila Elyasi, Masoumeh Khalili
Summary: Berberine effectively reduces iron deposition and related symptoms caused by iron overdose, and increases the activity of antioxidant enzymes, thus lowering oxidative conditions.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Neurosciences
S. Mokarrami, M. Jahanshahi, L. Elyasi, H. Badelisarkala, M. Khalili
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Mehrdad Jahanshahi, Masoumeh Khalili, Asra Margdari, Mahdi Aalikhani
Summary: This study demonstrates that naringin exhibits satisfying iron chelation capacity and has the potential to be a promising natural substitute for the treatment of iron overload disorders.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Masoumeh Khalili, Mohammad Ali Ebrahimzadeh, Mehrnoush Kosaryan
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
(2015)
Article
Pharmacology & Pharmacy
M. Khalili, T. Dehdar, F. Hamedi, M. A. Ebrahimzadeh, M. Karami
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2015)
Article
Pharmacology & Pharmacy
Mohammad Ali Ebrahimzadeh, Masoumeh Khalili, Negar Jafari, Giti Zareh, Davood Farzin, Gholamreza Amin
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Pharmacology & Pharmacy
Mohammad Ali Ebrahimzadeh, Masoumeh Khalili, Abbas Ali Dehpour
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Chemistry, Multidisciplinary
Masoumeh Khalili, Mohammad Ali Ebrahimzadeh, Mehrnoush Kosaryan, Ali Abbasi, Mohammad Azadbakht