Elevated amyloid beta disrupts the nanoscale organization and function of synaptic vesicle pools in hippocampal neurons

Synaptic Vesicle Recycling and the Endolysosomal System: A Reappraisal of Form and Function

(2022) Daniela Ivanova et al.   Frontiers in Synaptic Neuroscience

Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation

(2021) Daniela Anni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau

(2021) Henry B.C. Taylor et al.   Cell Reports

Real-time three-dimensional tracking of single vesicles reveals abnormal motion and pools of synaptic vesicles in neurons of Huntington's disease mice

(2021) Sidong Chen et al.   iScience

Misfolded amyloid-β-42 impairs the endosomal–lysosomal pathway

(2020) Karen E. Marshall et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nanoscale Remodeling of Functional Synaptic Vesicle Pools in Hebbian Plasticity

(2020) Stephanie Rey et al.   Cell Reports

Disorders of synaptic vesicle fusion machinery

(2020) Holly Melland et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic Vesicles Dynamics in Neocortical Epilepsy

(2020) Eleonora Vannini et al.   Frontiers in Cellular Neuroscience

Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease

(2019) Sarmi Sri et al.   Acta Neuropathologica Communications

Amyloid-β and Synaptic Vesicle Dynamics: A Cacophonic Orchestra

(2019) Francesca Fagiani et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic dysfunction in Alzheimer's disease: the effects of amyloid beta on synaptic vesicle dynamics as a novel target for therapeutic intervention

(2018) Pavlos Alifragis et al.   Neural Regeneration Research

Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies

(2018) Yu Chen et al.   PHARMACOLOGY & THERAPEUTICS

Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory

(2017) Agostino Palmeri et al.   JOURNAL OF NEUROSCIENCE

Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid

(2017) Jade Marsh et al.   NEUROBIOLOGY OF DISEASE

Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets

(2017) Ying C. Li et al.   PHARMACOLOGICAL REVIEWS

Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling

(2017) Vesna Lazarevic et al.   Frontiers in Molecular Neuroscience

APP—A Novel Player within the Presynaptic Active Zone Proteome

(2017) Jens Weingarten et al.   Frontiers in Molecular Neuroscience

A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration

(2016) Karen E. Marshall et al.   Scientific Reports

APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone

(2016) Melanie Laßek et al.   PLoS Computational Biology

Synaptic vesicle pools: Principles, properties and limitations

(2015) Milena Wagner Fowler et al.   EXPERIMENTAL CELL RESEARCH

Intrinsic membrane properties determine hippocampal differential firing pattern in vivo in anesthetized rats

(2015) Janina Kowalski et al.   HIPPOCAMPUS

Ultrastructural and functional fate of recycled vesicles in hippocampal synapses

(2015) Stephanie A. Rey et al.   Nature Communications

Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a

(2015) Yoosoo Yang et al.   Cell Reports

Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance

(2015) Arnold Bakker et al.   NeuroImage-Clinical

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Ultrastructural readout of functional synaptic vesicle pools in hippocampal slices based on FM dye labeling and photoconversion

(2014) Vincenzo Marra et al.   Nature Protocols

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

Deleterious effects of soluble amyloid-β oligomers on multiple steps of synaptic vesicle trafficking

(2013) Joohyun Park et al.   NEUROBIOLOGY OF DISEASE

Activity dynamics and behavioral correlates of CA3 and CA1 hippocampal pyramidal neurons

(2012) Kenji Mizuseki et al.   HIPPOCAMPUS

Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

(2012) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Recruitment of resting vesicles into recycling pools supports NMDA receptor-dependent synaptic potentiation in cultured hippocampal neurons

(2012) Arjuna Ratnayaka et al.   JOURNAL OF PHYSIOLOGY-LONDON

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Anti-epileptic drug shows benefit in AD mouse model

(2012) Man Tsuey Tse   NATURE REVIEWS DRUG DISCOVERY

A Preferentially Segregated Recycling Vesicle Pool of Limited Size Supports Neurotransmission in Native Central Synapses

(2012) Vincenzo Marra et al.   NEURON

Amyloid-β Acts as a Regulator of Neurotransmitter Release Disrupting the Interaction between Synaptophysin and VAMP2

(2012) Claire L. Russell et al.   PLoS One

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of Synaptic Vesicle Position on Release Probability and Exocytotic Fusion Mode

(2012) H. Park et al.   SCIENCE

Synaptic Vesicle Pools and Dynamics

(2012) A. A. Alabi et al.   Cold Spring Harbor Perspectives in Biology

Systematic Heterogeneity of Fractional Vesicle Pool Sizes and Release Rates of Hippocampal Synapses

(2011) Oliver Welzel et al.   BIOPHYSICAL JOURNAL

A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam

(2011) Anna L. Meehan et al.   JOURNAL OF NEUROPHYSIOLOGY

Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex

(2011) Sophie Sokolow et al.   NEUROBIOLOGY OF DISEASE

Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles

(2011) Teja W. Groemer et al.   PLoS One

A small pool of vesicles maintains synaptic activity in vivo

(2011) A. Denker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extrasynaptic vesicle recycling in mature hippocampal neurons

(2011) Arjuna Ratnayaka et al.   Nature Communications

Computational processing of optical measurements of neuronal and synaptic activity in networks

(2010) Mario M. Dorostkar et al.   JOURNAL OF NEUROSCIENCE METHODS

CDK5 Serves as a Major Control Point in Neurotransmitter Release

(2010) Sung Hyun Kim et al.   NEURON

A Vesicle Superpool Spans Multiple Presynaptic Terminals in Hippocampal Neurons

(2010) Kevin Staras et al.   NEURON

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Revisiting synaptic vesicle pool localization in theDrosophilaneuromuscular junction

(2009) Annette Denker et al.   JOURNAL OF PHYSIOLOGY-LONDON

Examining size–strength relationships at hippocampal synapses using an ultrastructural measurement of synaptic release probability

(2009) Tiago Branco et al.   JOURNAL OF STRUCTURAL BIOLOGY

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

The probability of neurotransmitter release: variability and feedback control at single synapses

(2009) Tiago Branco et al.   NATURE REVIEWS NEUROSCIENCE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Dendritic Activity Sets Release Probability at Hippocampal Synapses

(2008) Tiago Branco et al.   NEURON