Organic Anion Transporting Polypeptide 2B1 (OATP2B1) Genetic Variants: In Vitro Functional Characterization and Association With Circulating Concentrations of Endogenous Substrates

Further Evaluation of Coproporphyrins as Clinical Endogenous Markers for OATP1B

(2021) Sheng Feng et al.   JOURNAL OF CLINICAL PHARMACOLOGY

SLCO1B1: Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function.

(2021) Lingxin Zhang et al.   DRUG METABOLISM AND DISPOSITION

OATP2B1 – The underrated member of the organic anion transporting polypeptide family of drug transporters?

(2021) Jonny Kinzi et al.   BIOCHEMICAL PHARMACOLOGY

Role of OATP2B1 in drug absorption and drug-drug interactions

(2020) Mingqing Chen et al.   DRUG METABOLISM AND DISPOSITION

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Organic anion transporting polypeptide 2B1 (OATP2B1), an expanded substrate profile, does it align with OATP2B1’s hypothesized function?

(2020) Dallas Bednarczyk et al.   XENOBIOTICA

A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos

(2020) Elena V. Feofanova et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Substantially Increased Plasma Coproporphyrin‐I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population

(2020) Yosuke Suzuki et al.   CTS-Clinical and Translational Science

Functional Characterization Reveals the Significance of Rare Coding Variations in Human Organic Anion Transporting Polypeptide 2B1 (SLCO2B1)

(2020) Jingjie Yang et al.   MOLECULAR PHARMACEUTICS

Enantiospecific Pharmacogenomics of Fluvastatin

(2019) Päivi Hirvensalo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug–Drug Interaction and Associated Biomarker Levels in Healthy Volunteers

(2019) Sook Wah Yee et al.   CTS-Clinical and Translational Science

Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1

(2019) Samantha Medwid et al.   DRUG METABOLISM AND DISPOSITION

Clinical Investigation of Coproporphyrins as Sensitive Biomarkers to Predict Mild to Strong OATP1B-Mediated Drug–Drug Interactions

(2018) Annett Kunze et al.   CLINICAL PHARMACOKINETICS

Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium

(2018) Sook Wah Yee et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Food Effect on Rosuvastatin Disposition and Low-Density Lipoprotein Cholesterol

(2018) Cheynne C. McLean et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Apixaban and Rosuvas­­tatin Pharmacokinetics in Nonalcoholic Fatty Liver Disease

(2018) Rommel G. Tirona et al.   DRUG METABOLISM AND DISPOSITION

The scaffold protein PDZK1 modulates expression and function of the organic anion transporting polypeptide 2B1

(2018) Celio Ferreira et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Thyroid Hormones Are Transport Substrates and Transcriptional Regulators of Organic Anion Transporting Polypeptide 2B1

(2018) Henriette E. Meyer zu Schwabedissen et al.   MOLECULAR PHARMACOLOGY

Biomarkers for In Vivo Assessment of Transporter Function

(2018) Fabian Müller et al.   PHARMACOLOGICAL REVIEWS

Neurosteroid Transport in the Brain: Role of ABC and SLC Transporters

(2018) Markus Grube et al.   Frontiers in Pharmacology

Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance

(2018) Maciej J. Zamek-Gliszczynski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers

(2018) Daiki Mori et al.   Drug Metabolism and Pharmacokinetics

Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling

(2018) Toshiaki Nakano et al.   CIRCULATION

From Endogenous Compounds as Biomarkers to Plasma‐Derived Nanovesicles as Liquid Biopsy; Has the Golden Age of Translational PK ‐ ADME ‐ DDI Science Finally Arrived?

(2018) David Rodrigues et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects

(2018) Hong Shen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Germline variant in SLCO2B1 and response to abiraterone acetate plus prednisone (AA) in new onset metastatic castration-resistant prostate cancer (mCRPC)

(2018) Andrew W Hahn et al.   MOLECULAR CANCER THERAPEUTICS

Genetic variability and population diversity of the human SLCO (OATP) transporter family

(2018) Boyao Zhang et al.   PHARMACOLOGICAL RESEARCH

Organic anion transporting polypeptide 2B1 – More than a glass-full of drug interactions

(2018) Savannah J. McFeely et al.   PHARMACOLOGY & THERAPEUTICS

Characterization of OATP1B3 and OATP2B1 transporter expression in the islet of the adult human pancreas

(2017) Michelle Kim et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic ( SLCO2B1 and ABCG2 ), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP

(2017) Yushi Kashihara et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers

(2017) Issey Takehara et al.   PHARMACEUTICAL RESEARCH

Association of SLCO2B1 Genotypes With Time to Progression and Overall Survival in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer

(2016) Xiaodong Wang et al.   JOURNAL OF CLINICAL ONCOLOGY

Relationships between Endogenous Plasma Biomarkers of Constitutive Cytochrome P450 3A Activity and Single-Time-Point Oral Midazolam Microdose Phenotype in Healthy Subjects

(2015) Sarah J. Woolsey et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery

(2015) Janine Hussner et al.   VASCULAR PHARMACOLOGY

Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III

(2015) Dallas Bednarczyk et al.   XENOBIOTICA

Clinical and Pharmacogenetic Predictors of Circulating Atorvastatin and Rosuvastatin Concentrations in Routine Clinical Care

(2013) Marianne K. DeGorter et al.   Circulation-Cardiovascular Genetics

Effects of polymorphisms of theSLCO2B1transporter gene on the pharmacokinetics of montelukast in humans

(2013) Kyoung-Ah Kim et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Polymorphisms of the androgen transporting gene SLCO2B1 may influence the castration resistance of prostate cancer and the racial differences in response to androgen deprivation

(2013) N Fujimoto et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

(2013) Anne T Nies et al.   Genome Medicine

N-Methylnicotinamide Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving Multidrug and Toxin Extrusions (MATE1 and MATE2-K)

(2012) S Ito et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

(2012) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren

(2012) Tuija Tapaninen et al.   Pharmacogenetics and Genomics

SLCO2B1 and SLCO1B3 May Determine Time to Progression for Patients Receiving Androgen Deprivation Therapy for Prostate Cancer

(2011) Ming Yang et al.   JOURNAL OF CLINICAL ONCOLOGY

Microdosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1), and Interaction (Grapefruit Juice) Profiles of Celiprolol Following the Oral Microdose and Therapeutic Dose

(2011) Ichiro Ieiri et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake

(2011) M. Niemi et al.   PHARMACOLOGICAL REVIEWS

Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms

(2011) Guangju Zhai et al.   PLoS Genetics

Effect of Citrus Juice andSLCO2B1Genotype on the Pharmacokinetics of Montelukast

(2010) E. B. Mougey et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans

(2010) Junko Imanaga et al.   Pharmacogenetics and Genomics

Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers

(2010) Yumiko Akamine et al.   XENOBIOTICA

Contribution of organic anion transporting polypeptide OATP2B1 to amiodarone accumulation in lung epithelial cells

(2009) Satoru Seki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins

(2009) Michael J. Knauer et al.   CIRCULATION RESEARCH

Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs

(2009) G. Ahlin et al.   DRUG METABOLISM AND DISPOSITION

Human Platelets Express Organic Anion-Transporting Peptide 2B1, an Uptake Transporter for Atorvastatin

(2009) J. Niessen et al.   DRUG METABOLISM AND DISPOSITION

Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects

(2009) Lisa R. Treviño et al.   JOURNAL OF CLINICAL ONCOLOGY

Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response

(2009) Edward B. Mougey et al.   Pharmacogenetics and Genomics

Organic Anion Transporter 1B1: An Important Factor in Hepatic Thyroid Hormone and Estrogen Transport and Metabolism

(2008) Wendy M. van der Deure et al.   ENDOCRINOLOGY

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE