Attenuated SIRT1 Activity Leads to PER2 Cytoplasmic Localization and Dampens the Amplitude of Bmal1 Promoter-Driven Circadian Oscillation

Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases

(2021) Rezwana Ahmed et al.   Frontiers in Neuroscience

NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging

(2020) Daniel C. Levine et al.   MOLECULAR CELL

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism

(2020) Weiqi Hong et al.   Frontiers in Cell and Developmental Biology

Nicotinamide riboside—A missing piece in the puzzle of exercise therapy for older adults?

(2020) Carlo Custodero et al.   EXPERIMENTAL GERONTOLOGY

Over‐expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress‐induced premature senescence

(2020) Ardaning Nuriliani et al.   GENES TO CELLS

Replicative senescent human cells possess altered circadian clocks with a prolonged period and delayed peak-time

(2019) Rezwana Ahmed et al.   Aging-US

NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR

(2018) Jun Yoshino et al.   Cell Metabolism

mTOR signaling regulates central and peripheral circadian clock function

(2018) Chidambaram Ramanathan et al.   PLoS Genetics

Nicotinamide phosphoribosyltransferase delays cellular senescence by upregulating SIRT1 activity and antioxidant gene expression in mouse cells

(2017) Fiqri D. Khaidizar et al.   GENES TO CELLS

Targeting metabolism in cellular senescence, a role for intervention

(2017) Timothy Nacarelli et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

The Circadian NAD+ Metabolism: Impact on Chromatin Remodeling and Aging

(2016) Yasukazu Nakahata et al.   Biomed Research International

Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age

(2015) Ziv Zwighaft et al.   Cell Metabolism

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease

(2015) Emma L. James et al.   JOURNAL OF PROTEOME RESEARCH

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

(2014) Selma Masri et al.   CELL

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Positive Role for PERIOD in Mammalian Circadian Gene Expression

(2014) Makoto Akashi et al.   Cell Reports

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

NAD+metabolism: A therapeutic target for age-related metabolic disease

(2013) Laurent Mouchiroud et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

PML regulates PER2 nuclear localization and circadian function

(2012) Takao Miki et al.   EMBO JOURNAL

JNK regulates the photic response of the mammalian circadian clock

(2012) Hikari Yoshitane et al.   EMBO REPORTS

Aging Differentially Affects the Re-entrainment Response of Central and Peripheral Circadian Oscillators

(2012) M. T. Sellix et al.   JOURNAL OF NEUROSCIENCE

AMPK at the crossroads of circadian clocks and metabolism

(2012) Sabine D. Jordan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

(2012) Hassina Massudi et al.   PLoS One

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Age-Related Decline in Circadian Output

(2011) T. J. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

(2011) Katja A. Lamia et al.   NATURE

Regulation of metabolism: the circadian clock dictates the time

(2011) Saurabh Sahar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

(2010) Gad Asher et al.   CELL

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

“Clocks” in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging

(2009) Shin-ichiro Imai   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells

(2009) Eric E. Zhang et al.   CELL

The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors

(2009) M. Watson et al.   MOLECULAR AND CELLULAR BIOLOGY

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL