The Role of the Gastrointestinal System in Neuroinvasion by SARS-CoV-2

Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration

(2021) Mahsa Dolatshahi et al.   MOLECULAR NEUROBIOLOGY

Potential intestinal infection and faecal–oral transmission of SARS-CoV-2

(2021) Meng Guo et al.   Nature Reviews Gastroenterology & Hepatology

Infection Mechanism of SARS-COV-2 and Its Implication on the Nervous System

(2021) Edwin Estefan Reza-Zaldívar et al.   Frontiers in Immunology

Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2

(2020) Xi Xu et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS‐CoV, MERS‐CoV, and 2019‐nCoV

(2020) Jia Liu et al.   JOURNAL OF MEDICAL VIROLOGY

The neuroinvasive potential of SARS‐CoV2 may be at least partially responsible for the respiratory failure of COVID‐19 patients

(2020) Yan‐Chao Li et al.   JOURNAL OF MEDICAL VIROLOGY

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

(2020) Abdul Mannan Baig et al.   ACS Chemical Neuroscience

Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19

(2020) Ahmet Kursat Azkur et al.   ALLERGY

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

(2020) Yvan Jamilloux et al.   AUTOIMMUNITY REVIEWS

Can the enteric nervous system be an alternative entrance door in SARS-CoV2 neuroinvasion?

(2020) Giuseppe Esposito et al.   BRAIN BEHAVIOR AND IMMUNITY

Nervous system involvement after infection with COVID-19 and other coronaviruses

(2020) Yeshun Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Clinical Insights into the Gastrointestinal Manifestations of COVID-19

(2020) Jonathan Kopel et al.   DIGESTIVE DISEASES AND SCIENCES

Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms

(2020) Xi Jin et al.   GUT

Temporal Correlation Between Neurological and Gastrointestinal Symptoms of SARS-CoV-2

(2020) Mehmet Bostancıklıoğlu   INFLAMMATORY BOWEL DISEASES

Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study

(2020) Nan Yu et al.   LANCET INFECTIOUS DISEASES

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

Virology, Epidemiology, Pathogenesis, and Control of COVID-19

(2020) Yuefei Jin et al.   Viruses-Basel

COVID-19 and SARS-Cov-2 Infection: Pathophysiology and Clinical Effects on the Nervous System.

(2020) Hilal Abboud et al.   World Neurosurgery

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from the periphery to the brain

(2020) Zhengqian Li et al.   Frontiers of Medicine

Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review

(2020) V. Montalvan et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports

(2020) Souhel Najjar et al.   Journal of Neuroinflammation

Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 2019

(2020) Fabian Sanchis-Gomar et al.   MAYO CLINIC PROCEEDINGS

Gut microbiota and Covid-19- possible link and implications

(2020) Debojyoti Dhar et al.   VIRUS RESEARCH

Neuromechanisms of SARS-CoV-2: A Review

(2020) Marcos F. DosSantos et al.   Frontiers in Neuroanatomy

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

(2020) Michael T. Heneka et al.   Alzheimers Research & Therapy

Case Report: Benign Infantile Seizures Temporally Associated With COVID-19

(2020) Marcos García-Howard et al.   Frontiers in Pediatrics

Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach

(2020) Ahmad Abu Turab Naqvi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

SARS‐CoV ‐2 multifaceted interaction with the human host. Part II : Innate immunity response, immunopathology, and epigenetics

(2020) Tasnim H. Beacon et al.   IUBMB LIFE

Possible routes of SARS‐CoV‐2 invasion in brain: In context of neurological symptoms in COVID‐19 patients

(2020) Ashutosh Kumar et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination

(2020) Ariane Sternberg et al.   LIFE SCIENCES

Immunological co-ordination between gut and lungs in SARS-CoV-2 infection

(2020) Shruti Ahlawat et al.   VIRUS RESEARCH

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19

(2020) Donato Zipeto et al.   Frontiers in Immunology

Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches

(2020) Carolina Ferreira et al.   Microorganisms

Viral Infection-Induced Gut Dysbiosis, Neuroinflammation, and α-Synuclein Aggregation: Updates and Perspectives on COVID-19 and Neurodegenerative Disorders

(2020) Cristian Follmer   ACS Chemical Neuroscience

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

(2020) Jenny Meinhardt et al.   NATURE NEUROSCIENCE

Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome

(2020) Sonia Villapol   Translational Research

SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development

(2020) Mei-Yue Wang et al.   Frontiers in Cellular and Infection Microbiology

SARS CoV-2 Organotropism Associated Pathogenic Relationship of Gut-Brain Axis and Illness

(2020) Pottathil Shinu et al.   Frontiers in Molecular Biosciences

Gut Microbiota-targeted Interventions for Reducing the Incidence, Duration, and Severity of Respiratory Tract Infections in Healthy Non-elderly Adults

(2020) J Philip Karl   MILITARY MEDICINE

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

Gut Microbiota and IGF-1

(2018) Jing Yan et al.   CALCIFIED TISSUE INTERNATIONAL

The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective

(2018) Sofia Cussotto et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa

(2018) Robert Dantzer   PHYSIOLOGICAL REVIEWS

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis

(2018) Bruno Bonaz et al.   Frontiers in Neuroscience

Homeostatic Immunity and the Microbiota

(2017) Yasmine Belkaid et al.   IMMUNITY

The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract

(2017) Bruno Bonaz et al.   Frontiers in Immunology

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

Collective unconscious: How gut microbes shape human behavior

(2015) Timothy G. Dinan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Middle East respiratory syndrome

(2015) Alimuddin Zumla et al.   LANCET

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Stress Induces Endotoxemia and Low-Grade Inflammation by Increasing Barrier Permeability

(2015) Karin de Punder et al.   Frontiers in Immunology

The Gut Microbiome and the Brain

(2014) Leo Galland   JOURNAL OF MEDICINAL FOOD

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

Gut–brain axis: how the microbiome influences anxiety and depression

(2013) Jane A. Foster et al.   TRENDS IN NEUROSCIENCES

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Classification and functions of enteroendocrine cells of the lower gastrointestinal tract

(2011) Ashok R. Gunawardene et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters

(2010) Keiji Kuba et al.   PHARMACOLOGY & THERAPEUTICS

Recently Discovered Human Coronaviruses

(2009) Brigitte A. Wevers et al.   CLINICS IN LABORATORY MEDICINE

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE