Activation of ERK–Drp1 signaling promotes hypoxia‐induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity

Parkin overexpression attenuates Aβ-induced mitochondrial dysfunction in HEK293 cells by restoring impaired mitophagy

(2020) Hongmei Wang et al.   LIFE SCIENCES

Stat2-Drp1 mediated mitochondrial mass increase is necessary for pro-inflammatory differentiation of macrophages

(2020) Weihua Yu et al.   Redox Biology

Dynamin-like protein 1 cleavage by calpain in Alzheimer’s disease

(2019) Sirui Jiang et al.   AGING CELL

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

(2019) P. Hemachandra Reddy et al.   Cells

Mitochondrial dynamics and transport in Alzheimer's disease

(2019) Padraig J. Flannery et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dynamics of Dynamin-Related Protein 1 in Alzheimer’s Disease and Other Neurodegenerative Diseases

(2019) Darryll Oliver et al.   Cells

Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates

(2018) Feng Zhang et al.   Frontiers in Neuroscience

Rice Bran Extract Compensates Mitochondrial Dysfunction in a Cellular Model of Early Alzheimer's Disease

(2018) Stephanie Hagl et al.   JOURNAL OF ALZHEIMERS DISEASE

Age-Dependent Decrease of Mitochondrial Complex II Activity in a Familial Mouse Model for Alzheimer’s Disease

(2018) Tim L. Emmerzaal et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration

(2018) Natalia N. Nalivaeva et al.   Frontiers in Neuroscience

Inhibition of mitochondrial fragmentation protects against Alzheimer’s disease in rodent model

(2017) Wenzhang Wang et al.   HUMAN MOLECULAR GENETICS

Investigation on the Role of BDNF in the Benefits of Blueberry Extracts for the Improvement of Learning and Memory in Alzheimer’s Disease Mouse Model

(2017) Long Tan et al.   JOURNAL OF ALZHEIMERS DISEASE

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

(2017) Antero Salminen et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

(2017) Seung Hyun Baek et al.   JOURNAL OF NEUROSCIENCE

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

(2017) Yu-Lu Cao et al.   NATURE

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

(2016) Ramesh Kandimalla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial dynamics following global cerebral ischemia

(2016) Rita Kumar et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer’s disease

(2016) R Derungs et al.   MOLECULAR PSYCHIATRY

Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

(2016) Javier Prieto et al.   Nature Communications

Synergistic effects of β-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells

(2015) Bumsup Kwon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells

(2015) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

Thiacremonone Potentiates Anti-Oxidant Effects to Improve Memory Dysfunction in an APP/PS1 Transgenic Mice Model

(2015) Hyung-Mun Yun et al.   MOLECULAR NEUROBIOLOGY

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease

(2014) Ignacio Pedrós et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation

(2014) Laura Asnaghi et al.   PLoS One

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

(2013) Xueqi Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Down-regulation of Mortalin Exacerbates Aβ-mediated Mitochondrial Fragmentation and Dysfunction

(2013) So Jung Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model

(2013) Hong Xie et al.   JOURNAL OF NEUROSCIENCE

Diammonium Glycyrrhizinate Attenuates Aβ1-42-Induced Neuroinflammation and Regulates MAPK and NF-κB PathwaysIn VitroandIn Vivo

(2012) Hui Zhao et al.   CNS Neuroscience & Therapeutics

Cell Surface Expression of the Major Amyloid-β Peptide (Aβ)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK) and Dephosphorylation by Protein Phosphatase 1a

(2012) Naomasa Kakiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Interleukin Receptor-Associated Kinase 4 Signaling Suppresses Amyloid Pathology and Alters Microglial Phenotype in a Mouse Model of Alzheimer's Disease

(2012) B. Cameron et al.   JOURNAL OF NEUROSCIENCE

The Potential Dual Effects of Anesthetic Isoflurane on Hypoxia-Induced Caspase-3 Activation and Increases in β-Site Amyloid Precursor Protein-Cleaving Enzyme Levels

(2011) Chuxiong Pan et al.   ANESTHESIA AND ANALGESIA

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Sleep-Disordered Breathing, Hypoxia, and Risk of Mild Cognitive Impairment and Dementia in Older Women

(2011) Kristine Yaffe et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia

(2011) Hyungsoo Kim et al.   MOLECULAR CELL

Physiological hypoxia promotes lipid raft and PI3K-dependent activation of MAPK 42/44 in leukemia cells

(2010) M Fiegl et al.   LEUKEMIA

Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways

(2010) H. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

(2009) Zhiyin Song et al.   MOLECULAR BIOLOGY OF THE CELL

CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

(2008) Xiao-Jian Han et al.   JOURNAL OF CELL BIOLOGY

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

(2007) Liang Li et al.   NEUROBIOLOGY OF AGING