Swertia chirayita suppresses the growth of non-small cell lung cancer A549 cells and concomitantly induces apoptosis via downregulation of JAK1/STAT3 pathway

Carvacrol Exhibits Chemopreventive Potential against Cervical Cancer Cells via Caspase-Dependent Apoptosis and Abrogation of Cell Cycle Progression

(2021) Afza Ahmad et al.   Anti-Cancer Agents in Medicinal Chemistry

Role of JAK/STAT3 Signaling in the Regulation of Metastasis, the Transition of Cancer Stem Cells, and Chemoresistance of Cancer by Epithelial–Mesenchymal Transition

(2020) Wook Jin   Cells

Anti-Cancer Activity of Catechin against A549 Lung Carcinoma Cells by Induction of Cyclin Kinase Inhibitor p21 and Suppression of Cyclin E1 and P–AKT

(2020) Haiyan Sun et al.   Applied Sciences-Basel

Leishmanial CpG DNA nanovesicles: A propitious prophylactic approach against visceral leishmaniasis

(2020) Rohit Kumar Tiwari et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and reactive oxygen species generation in A549 and NCI-H1299 non-small cell lung cancer cells

(2019) Jiyon Lee et al.   BMC Complementary and Alternative Medicine

p21 in Cancer Research

(2019) Shamloo et al.   Cancers

In Vitro and In Vivo Antitumor Activity of Cucurbitacin C, a Novel Natural Product From Cucumber

(2019) Dinglan Wu et al.   Frontiers in Pharmacology

Expression patterns of three JAK–STAT pathway genes in feather follicle development during chicken embryogenesis

(2019) Yingfeng Tao et al.   GENE EXPRESSION PATTERNS

Oxidation, glycation and glycoxidation—The vicious cycle and lung cancer

(2018) Saheem Ahmad et al.   SEMINARS IN CANCER BIOLOGY

Lobocrassin B Induces Apoptosis of Human Lung Cancer and Inhibits Tumor Xenograft Growth

(2017) Meng-Xian Lin et al.   Marine Drugs

Cytotoxicity of methanolic extract of Swertia petiolata against gastric cancer cell line SNU-5 is via induction of apoptosis

(2017) Qun-Ying He et al.   SOUTH AFRICAN JOURNAL OF BOTANY

A systematic review of the protective role of swertiamarin in cardiac and metabolic diseases

(2016) Xin Yu Leong et al.   BIOMEDICINE & PHARMACOTHERAPY

PTBP1 modulation of MCL1 expression regulates cellular apoptosis induced by antitubulin chemotherapeutics

(2016) J Cui et al.   CELL DEATH AND DIFFERENTIATION

IL-6 mediates the signal pathway of JAK-STAT3-VEGF-C promoting growth, invasion and lymphangiogenesis in gastric cancer

(2016) GUIBIN ZHAO et al.   ONCOLOGY REPORTS

Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells

(2015) Neha Kaushik et al.   Scientific Reports

A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells

(2013) Chi-Tai Yeh et al.   CARCINOGENESIS

Hypoxia-induced decreases in SOCS3 increase STAT3 activation and upregulate VEGF gene expression

(2012) Kiyotaka Yokogami et al.   Brain Tumor Pathology

STAT3 can serve as a hit in the process of malignant transformation of primary cells

(2012) M Demaria et al.   CELL DEATH AND DIFFERENTIATION

Targeting the Interleukin-6/Jak/Stat Pathway in Human Malignancies

(2012) Pasquale Sansone et al.   JOURNAL OF CLINICAL ONCOLOGY

JAK2 the future: therapeutic strategies for JAK-dependent malignancies

(2012) Lindsay M. LaFave et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Plasmid-based Stat3 siRNA delivered by hydroxyapatite nanoparticles suppresses mouse prostate tumour growth in vivo

(2011) Zuo-Wen Liang et al.   ASIAN JOURNAL OF ANDROLOGY

IL-6 Production Is Positively Regulated by Two Distinct Src Homology Domain 2-Containing Tyrosine Phosphatase-1 (SHP-1)-Dependent CCAAT/Enhancer-Binding Protein   and NF- B Pathways and an SHP-1-Independent NF- B Pathway in Lipopolysaccharide-Stimulated Bone Marrow-Derived Macrophages

(2011) D. Rego et al.   JOURNAL OF IMMUNOLOGY

Atmospheric-Pressure Plasma Jet Induces Apoptosis Involving Mitochondria via Generation of Free Radicals

(2011) Hak Jun Ahn et al.   PLoS One

Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK

(2010) Alina Felicia Nica et al.   CELL CYCLE

STAT3 as a target for inducing apoptosis in solid and hematological tumors

(2008) Khandaker Al Zaid Siddiquee et al.   CELL RESEARCH

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY