Review
Gastroenterology & Hepatology
Taher Omari, Ali Zifan, Charles Cock, Ravinder K. Mittal
Summary: Esophageal peristalsis is a complex process involving both inhibition and excitation. Abnormalities in this process can lead to dysphagia and other swallowing difficulties. Studying the distensibility and contraction characteristics of the esophagus during peristalsis can provide valuable insights for the development of new treatments for patients with swallowing disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Dhyanesh A. Patel, Rena Yadlapati, Michael F. Vaezi
Summary: This review discusses the current approach to diagnosis and therapeutics of various esophageal motility disorders, which is of great significance in improving the quality of life for patients.
Review
Gastroenterology & Hepatology
Pierfrancesco Visaggi, Matteo Ghisa, Brigida Barberio, Elisa Marabotto, Nicola de Bortoli, Edoardo Savarino
Summary: Esophageal motor abnormalities are common in patients with eosinophilic esophagitis (EoE) and may contribute to symptoms. Eosinophils influence esophageal motility, and some motility abnormalities can be improved after medical treatment.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Medicine, General & Internal
Daniel L. Cohen, Anton Bermont, Vered Richter, Narjes Azzam, Haim Shirin, Ram Dickman, Amir Mari
Summary: The study found that integrated relaxation pressure (IRP) can distinguish between the reflux-predominant and dysphagia-predominant phenotypes in patients with absent contractility (AC). This may have important clinical implications, as procedures such as fundoplication may benefit patients with reflux and a low IRP, while procedures like peroral endoscopic myotomy (POEM) may benefit patients with dysphagia and a relatively high IRP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Federica Riccio, Mario Costantini, Renato Salvador
Summary: Accurate diagnosis is crucial for successful treatment of achalasia, with barium swallow, upper endoscopy, and high-resolution manometry providing essential information about anatomy, absence of other diseases, and type of achalasia. Prognostic value is also found in high-resolution manometry, with best treatment results obtained in type II achalasia according to the Chicago classification. Additional imaging tests such as abdominal CT scanning and endoscopic ultrasound may be necessary if malignancy is suspected.
WORLD JOURNAL OF SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Luca Giulini, Sumeet K. Mittal, Takahiro Masuda, Deepika Razia, Mate Csucska, Rajat Walia, Michael A. Smith, Ross M. Bremner
Summary: Esophageal peristalsis can improve after lung transplant, especially in patients with obstructive lung disease or pulmonary arterial hypertension. However, patients with restrictive lung disease and scleroderma are unlikely to experience peristalsis improvement. Subjective esophagram assessment may help predict peristalsis improvement in patients with restrictive lung disease without scleroderma.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Gastroenterology & Hepatology
Satsuki Takahashi, Tomoaki Matsumura, Tatsuya Kaneko, Mamoru Tokunaga, Hirotaka Oura, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Naoki Akizue, Yuki Ohta, Atsuko Kikuchi, Mai Fujie, Keiko Saito, Kenichiro Okimoto, Daisuke Maruoka, Tomoo Nakagawa, Makoto Arai, Jun Kato, Naoya Kato
Summary: This study found that different types of EMDs have distinct characteristics. Cigarette smoking and high body mass index were associated with esophageal hypermotility. Assessment of dysphagia symptom scores may help identify patients with EMDs.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Jeanine Wakim El-Khoury, John E. Pandolfino, Peter J. Kahrilas, Bidemi Godo, Domenico A. Farina, Wenjun Kou, Dustin A. Carlson
Summary: This study aimed to describe the changes in FLIP metrics during FLIP emptying, that is, reduced volume distension. The results showed that isotonic or auxotonic relaxation of the lower esophageal sphincter occurs with reduced volume distension in patients with achalasia and normal motility. The study also supports the importance of utilizing a standardized FLIP motility study protocol to provide reliable and generalizable FLIP metrics to facilitate diagnosis of esophageal motility disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Oscar V. Hernandez Mondragon, Omar M. Solorzano Pineda
Summary: The concept of third space endoscopy was first described in 2007 and was performed in humans in 2010 for the treatment of esophageal achalasia. Since then, esophageal endoscopic myotomy has been successfully performed in over 10,000 patients worldwide. It has been proven to be a safe and effective treatment for various gastrointestinal diseases, including achalasia and refractory gastroparesis. This minimal invasive procedure has shown excellent outcomes and is now considered the first option in certain clinical scenarios.
MINERVA GASTROENTEROLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Fernando A. M. Herbella, Leonardo M. Del Grande, Francisco Schlottmann, Marco G. Patti
Summary: The Chicago Classification 4.0 introduces new concepts for the diagnosis of achalasia, potentially reducing unnecessary treatment. Conditions such as esophagogastric junction outflow obstruction, distal esophageal spasm, and hypercontractile esophagus are now considered clinically significant only in certain conditions, leading to a potential decrease in treatment, especially peroral endoscopic myotomy, solely based on manometric diagnosis.
ADVANCES IN THERAPY
(2021)
Article
Otorhinolaryngology
Daniel L. Cohen, Basem Hijazi, Ali Omari, Anton Bermont, Haim Shirin, Helal Said Ahmad, Narjes Azzam, Fahmi Shibli, Ram Dickman, Amir Mari
Summary: This study compared the demographic, clinical, endoscopic, and manometric findings of achalasia patients between Israeli Arabs and Israeli Jews. It found that Israeli Arab achalasia patients had different clinical symptoms and higher integrated relaxation pressure compared to Israeli Jewish patients.
Article
Gastroenterology & Hepatology
Sawangpong Jandee, Kasemsak Jandee
Summary: This study evaluated the diagnostic yield of high-resolution manometry in Thai patients, finding the highest yield in dysphagia patients. However, the test was not as beneficial in detecting clinically relevant esophageal motor disorders in patients presenting with non-dysphagia symptoms.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Eun Jeong Gong, Soo In Choi, Bong Eun Lee, Yang Won Min, Yu Kyung Cho, Kee Wook Jung, Ji Hyun Kim, Moo In Park
Summary: This study investigated the current practice of esophageal high-resolution manometry (HRM) in Korea and found variations among centers, although there was general agreement in data analysis. Efforts are needed to develop a standardized protocol for HRM measurement.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Matteo Ghisa, Giorgio Laserra, Elisa Marabotto, Sebastiano Ziola, Salvatore Tolone, Nicola de Bortoli, Marzio Frazzoni, Aurelio Mauro, Roberto Penagini, Vincenzo Savarino, Brigida Barberio, Edoardo Giovanni Giannini, Patrizia Zentilin, C. Prakash Gyawali, Edoardo Savarino
Summary: Achalasia and obstructive motor disorders were found in almost 15% of patients with EoE, suggesting that esophageal eosinophilia might be causing these disorders. Patients who do not respond to standard treatments may require targeted muscle disruption.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Otorhinolaryngology
Daniel L. Cohen, Anton Bermont, Vered Richter, Eyal Avivi, Amir Mari, Haim Shirin
Summary: High-resolution manometry (HRM) is the preferred diagnostic method for esophageal motility disorders, but it can be challenging to perform and tolerated poorly. This study compared HRM success rates in patients with epiphrenic diverticula (ED), achalasia, and controls. The study found that ED was associated with a lower success rate of HRM, mainly due to difficulties in traversing the esophagogastric junction. The size of the diverticulum also played a role in the success of HRM. Alternative methods, such as endoscopy-assisted HRM, should be considered for evaluating motility in patients with ED.
Article
Gastroenterology & Hepatology
Kazuhide Matsumoto, Nao Fujimori, Yoshitaka Hata, Yosuke Minoda, Masatoshi Murakami, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Takamasa Oono, Eikichi Ihara, Kohei Nakata, Masafumi Nakamura, Takeo Yamamoto, Yutaka Koga, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa
Summary: This study investigated the clinical characteristics of ampullary neuroendocrine neoplasms (NENs) and found distinct differences between ampullary NENs and pancreatic NENs, such as higher incidences of NEC and cholangitis in ampullary NENs. Furthermore, the study discovered identifiable distinctions between ampullary NETs and NECs through endoscopic findings.
DIGESTIVE DISEASES
(2023)
Article
Gastroenterology & Hepatology
Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa
Summary: This study investigated the region-specific role of the M-3 receptor in gastrointestinal motility using a novel positive allosteric modulator (PAM-369). The results showed that PAM-369 selectively potentiated the M-3 receptor without agonistic or antagonistic activity and increased small intestinal transit in mice. However, it had no effect on colonic transit. This study provides the first direct evidence of the different functional roles of the M-3 receptor between the small intestine and colon.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Shohei Hamada, Eikichi Ihara, Chikako Yoshitake, Taisuke Inada, Hiroki Fukuya, Akito Ohkubo, Naru Tomoeda, Yoichiro Iboshi, Yorinobu Sumida, Daisuke Yoshimura, Makoto Nakamuta, Naohiko Harada
Summary: Endoscopic submucosal dissection (ESD) is a method used to treat early epithelial tumors of the gastrointestinal tract, but delayed perforation is a problematic complication. To address this issue, researchers have developed a simple and promising closure technique.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Yoichiro Iboshi, Yorinobu Sumida, Eikichi Ihara, Hiroyuki Fujii, Naohiko Harada, Makoto Nakamuta, Yoshihiro Ogawa
Summary: This article presents a novel salvage procedure, called over-the-catheter endoscope replacement (OCER), for patients with malignant colonic obstruction (MCO) when the target obstructing lesion (TOL) is not directly accessible by a large-caliber endoscope (LCE). By utilizing an ultraslim endoscope and a guidewire, the TOL can be traversed and then replaced by an LCE to successfully deliver a self-expandable metallic stent (SEMS).
DIGESTIVE ENDOSCOPY
(2022)
Editorial Material
Gastroenterology & Hepatology
Kosuke Maehara, Mitsuru Esaki, Yorinobu Sumida, Shin-ichro Fukuda, Yosuke Minoda, Eikichi Ihara, Hirotada Akiho
Editorial Material
Gastroenterology & Hepatology
Yoshihisa Shoguchi, Mitsuru Esaki, Yosuke Minoda, Xiaopeng Bai, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa
Article
Surgery
Yosuke Minoda, Eikichi Ihara, Soichi Itaba, Yorinobu Sumida, Kazuhiro Haraguchi, Akira Aso, Takahiro Mizutani, Takashi Osoegawa, Mitsuru Esaki, Shuzaburo Nagatomo, Kei Nishioka, Kazumasa Muta, Xiaopeng Bai, Haruei Ogino, Nao Fujimori, Daisuke Tsurumaru, Kenoki Ohuchida, Hu Qingjiang, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa
Summary: Mucosal incision-assisted biopsy (MIAB) is a safe procedure with minimal impact on postoperative prognosis for sampling gastric subepithelial lesions (SELs). MIAB releases some tumor cells after damaging the SEL's pseudocapsule, but it does not significantly affect the 5-year disease-free survival rate.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Editorial Material
Gastroenterology & Hepatology
Yusuke Suzuki, Takashi Osoegawa, Masaru Kubokawa, Mitsuru Esaki, Yosuke Minoda, Haruei Ogino, Eikichi Ihara
Article
Gastroenterology & Hepatology
Yoshitaka Hata, Hiroki Sato, Yuto Shimamura, Hirofumi Abe, Akio Shiwaku, Junya Shiota, Chiaki Sato, Masaki Ominami, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Eikichi Ihara, Haruhiro Inoue
Summary: POEM is an effective treatment for patients with esophageal motility disorders. However, the impact of this procedure on HRM findings and its association with post-POEM outcomes remain unclear. This study found that pre-POEM HRM results and the extent of gastric myotomy were predictive factors of post-POEM HRM results. Furthermore, peristalsis recovery was influenced by pre-POEM HRM results and the presence of esophageal dilation.
GASTROINTESTINAL ENDOSCOPY
(2023)
Letter
Gastroenterology & Hepatology
Mitsuru Esaki, Yosuke Minoda, Eikichi Ihara
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mitsuru Esaki, Eikichi Ihara, Yorinobu Sumida, Hiroyuki Fujii, Shunsuke Takahashi, Kazuhiro Haraguchi, Tsutomu Iwasa, Shinichi Somada, Yosuke Minoda, Haruei Ogino, Koshiro Tagawa, Yoshihiro Ogawa
Summary: This study aimed to compare the treatment outcomes of hybrid endoscopic submucosal dissection (H-ESD) and conventional endoscopic submucosal dissection (C-ESD) for small early gastric neoplasms (EGNs). The results showed that H-ESD had significantly shorter procedure time than C-ESD, with comparable curability and safety. Therefore, H-ESD could be a good option for the endoscopic treatment of small EGNs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Yusuke Suzuki, Mitsuru Esaki, Taisuke Inada, Yosuke Minoda, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa
Article
Gastroenterology & Hepatology
Yosuke Minoda, Mitsuru Esaki, Eikichi Ihara, Shuzaburo Nagatomo, Kei Nishioka, Nao Fujimori, Haruei Ogino, Xiaopeng Bai, Yoshimasa Tanaka, Takatoshi Chinen, Qingjiang Hu, Mitsuhiko Ota, Shinya Umekita, Hidetaka Yamamoto, Yoshihiro Ogawa
Summary: A new diagnostic method using high-frequency impedance (H-impedance) measured by an EUS-FNB needle was developed to differentiate between gastric GI stromal tumor (GIST) and non-GIST. The study showed a significant positive correlation between H-impedance and cell density. This method has high accuracy and sensitivity in diagnosing GISTs and non-GISTs, and is not affected by lesion size.
GASTROINTESTINAL ENDOSCOPY
(2023)
Editorial Material
Gastroenterology & Hepatology
Kazuo Shiotsuki, Yorinobu Sumida, Mitsuru Esaki, Yosuke Minoda, Shin-ichiro Fukuda, Eikichi Ihara, Hirotada Akiho
Editorial Material
Gastroenterology & Hepatology
Yosuke Minoda, Nao Fujimori, Mitsuru Esaki, Shuzaburo Nagatomo, Yasuhiro Komori, Keijiro Ueda, Eikichi Ihara